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SAE-14 - ≥98% , CAS No.1241280-25-0
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade
≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC 50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC 50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice
In Vitro
SAE-14 (compound SAE-14) can able to antagonize 7α, 25-OHC–induced calcium mobilization with an IC 50 value below 50 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: The human leukemia (HL)-60 cells Concentration: 5×of the antagonist Incubation Time: 15 min Result: Had GPR183-specific (IC 50 : 28.5nM) and abolished 7a, 25-OHC–induced calcium mobilization in the HL-60 cells.
In Vivo
SAE-14 (compound SAE-14) (i.th.; 2.9 µM; once) can reverse nerve injury-induced allodynia in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male and female ICR mice Dosage: 2.9 µM Administration: intrathecal (i.th.) injections; 2.9 µM; once Result: Reversed CCI-induced mechanical allodynia in a time-dependent manner.
Form:Solid
IC50& Target:IC50: 28.5 nM (GPR183)
Specifications
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC 50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC 50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice.
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥98%
Names and Identifiers
| Canonical Smiles | O=C(NC1=CC(N2CCOCC2)=CC(F)=C1)CCC3=CC=C(F)C(F)=C3 |
|---|---|
| Molecular Weight | 364.36 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
| Solubility | DMSO : 100 mg/mL (274.45 mM; ultrasonic and warming and heat to 60°C) |
|---|
Solution Calculators
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