SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC 50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC 50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice
In Vitro
SAE-14 (compound SAE-14) can able to antagonize 7α, 25-OHC–induced calcium mobilization with an IC 50 value below 50 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: The human leukemia (HL)-60 cells Concentration: 5×of the antagonist Incubation Time: 15 min Result: Had GPR183-specific (IC 50 : 28.5nM) and abolished 7a, 25-OHC–induced calcium mobilization in the HL-60 cells.
In Vivo
SAE-14 (compound SAE-14) (i.th.; 2.9 µM; once) can reverse nerve injury-induced allodynia in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male and female ICR mice Dosage: 2.9 µM Administration: intrathecal (i.th.) injections; 2.9 µM; once Result: Reversed CCI-induced mechanical allodynia in a time-dependent manner.
Form:Solid
IC50& Target:IC50: 28.5 nM (GPR183)
Specifiche
Specifiche e purezza
≥98%
Meccanismi biochimici e fisiologici
SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC 50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC 50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice.
Condizioni di conservazione di stoccaggio
Store at -20°C
Spedito in
Ice chest + Ice pads
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Purezza
≥98%
Nomi e identificatori
Sorrisi canonici
O=C(NC1=CC(N2CCOCC2)=CC(F)=C1)CCC3=CC=C(F)C(F)=C3
Peso molecolare
364.36
Dati avanzati
Certificati (CoA, COO, BSE/TSE e tabella di analisi)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Proprietà chimiche e fisiche
Solubilità
DMSO : 100 mg/mL (274.45 mM; ultrasonic and warming and heat to 60°C)
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