Sertraline HCl - ≥98%(HPLC) , CAS No.79559-97-0

CAS: 79559-97-0 Cat. No.: S129789 Formula: C₁₇H₁₇Cl₂N.HCl Peso molecolare: 342.69 Numero EC: 616-702-0

QUALITÀ & PUREZZA ≥98%(HPLC)

Synonyms

Sertraline hydrochloride [USAN]|Sertraline hydrochloride- Bio-X|Atruline|Sertraline Hydrochloride (1S-cis)-Isomer|Zoloft (TN)|1-Naphthalenamine, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, hydrochloride, (1S-cis)-|Hydrochloride, Sertraline|Sertraline for system suitability|SERTRALINE HYDROCHLORIDE [ORANGE BOOK]|SERTRALINE HYDROCHLORIDE [EP IMPURITY]|SERTRALINE HYDROCHLORIDE [WHO-DD]|SERTRALINE HYDROCHLORIDE [JAN]|(1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride|Sertraline (as hydrochloride)|Tatig|(+/-)-Sertraline Hydrochloride|(1R,4S)-Sertraline Hydrochloride|Sertraline HCl|SERTRALINE HYDROCHLORIDE (USP MONOGRAPH)|(1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride|(+)-sertraline hydrochloride|(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride|Lustral|SERTRALINE HYDROCHLORIDE [VANDF]|Serlift|SERTRALINE HYDROCHLORIDE [USP-RS]|SERTRALINE HYDROCHLORIDE (MART.)|SERTRALINE HYDROCHLORIDE (USP-RS)|(1S,4S)-1-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-4-(methylamino)naphthalene Hydrochloride|Serad|SERTRALINE HYDROCHLORIDE (EP MONOGRAPH)|Sertraline.HCl|(1R,4S)-SERTRALINE HCL|(1RS,4SR)-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine Hydrochloride|(1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-aminium chloride|(+)-cis-(1S,4S)-1-methylamino-4-(3,4-dichlorophenyl)tetralin hydrochloride|rac-cis-Sertraline Hydrochloride|CP-51974-1|Sertraline hydrochloride|CP-51974-1 HCl|SERTRALINE HYDROCHLORIDE [MI]|Sertraline for peak identification|Zoloft|Sertraline hydrochloride (USAN:USP)|Pharmakon1600-01505262|Sertraline hydrochloride (JAN/USP)|Sertraline hydrochloride impurity Standard|C17H17Cl2N.HCl|SERTRALINE HYDROCHLORIDE (EP IMPURITY)|SERTRALINE HYDROCHLORIDE [MART.]|SERTRALINE HYDROCHLORIDE [USP MONOGRAPH]|(1S-cis)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride|Aremis|SERTRALINE HYDRECHLORIDE|CP-5197401|Sertraline hydrochloride [USAN:USP]|Gladem|Sertraline (hydrochloride)|Cis-N-Methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenaminehydrochloride|(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthylamine hydrochloride|Adjuvin

Storage

Store at 2-8°C

Shipped In

Wet ice

Panoramica

Sertraline HCl is a 5-HT antagonist with Ki of 13 nM.
A selective ST inhibitor.

Specifiche

Sinonimi

Sertraline hydrochloride [USAN] | Sertraline hydrochloride- Bio-X | Atruline | Sertraline Hydrochloride (1S-cis)-Isomer | Zoloft (TN) | 1-Naphthalenamine, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, hydrochloride, (1S-cis)- | Hydrochloride, Sertraline | Sertraline for system suitability | SERTRALINE HYDROCHLORIDE [ORANGE BOOK] | Mostra altro

Specifiche e purezza

≥98%(HPLC)

Meccanismi biochimici e fisiologici

Sertraline HCl is a selective and potent inhibitor of ST (serotonin transporter), increasing availability of serotonin in the brain. Sertraline displays antiproliferative activity on human colorectal carcinoma cells.Selective serotonin reuptake inhibitor

Condizioni di conservazione di stoccaggio

Store at 2-8°C

Spedito in

Wet ice

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purezza

≥98%(HPLC)

Nomi e identificatori

Pubchem Sid

504753902

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504753902

Sorrisi canonici

CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl.Cl

IUPAC Name

(1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine;hydrochloride

InChIKey

BLFQGGGGFNSJKA-XHXSRVRCSA-N

INCHI

1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1

Isomeri SMILES

CN[C@H]1CC[C@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl.Cl

WGK Germania

3

RTECS

QJ0352070

CAS alternativo

79617-96-2；79617-95-1，79617-89-3

Peso molecolare

342.69

Reaxy-Rn

5783715

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Tetralins
      • Subclass Tametralines

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Tetralins
• Subclass: Tametralines
• Intermediate Tree Nodes: Not available
• Direct Parent: Tametralines
• Alternative Parents: Dichlorobenzenes Aralkylamines Aryl chlorides Dialkylamines Organopnictogen compounds Organochlorides Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Tametraline - 1,2-dichlorobenzene - Chlorobenzene - Halobenzene - Aralkylamine - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Secondary aliphatic amine - Secondary amine - Organochloride - Organohalogen compound - Hydrocarbon derivative - Organopnictogen compound - Organic nitrogen compound - Amine - Organonitrogen compound - Hydrochloride - Aromatic homopolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as tametralines. These are compounds containing a tametraline moiety, which consists of a tetrahydronaphthalene linked to a phenyl group to form N-methyl-4-phenyl-1,2,3,4-tetrahydronaphthalen-1-amine skeleton.
• External Descriptors: hydrochloride

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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Meccanismi d'azione

Proprietà chimiche e fisiche

• Solubilità: Soluble in DMSO (>25 mg/ml), ethanol (10 mg/ml), water (3 mg/ml), 0.1N HCl (0.51 mg/ml), isopropyl alcohol (4.3 mg/ml), chloroform (110 mg/ml), and dimethylsulfoxide (147 mg/ml).
• Sensibilità: Moisture sensitive.
• Rotazione specifica [α]: 38°C
• Punto di fusione (°C): 245°C
• Peso molecolare: 342.700 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 341.05 Da
• Monoisotopic Mass: 341.05 Da
• Topological Polar Surface Area: 12.000 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 322.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3