SIB 1757 - Moligand™, ≥98% , Allosteric modulator of mGlu 5 receptor, CAS No.31993-01-8, Allosteric modulator of mGlu 5 receptor

CAS: 31993-01-8 Cat. No.: S287942 Formula: C₁₂H₁₁N₃O Peso molecolare: 213.24 Numero EC: 636-525-2 PubChem CID: 5218788

GRADE & PURITY Moligand™, ≥98%

Synonyms

NCGC00185991-01 | CHEBI:93722 | SR-01000076142-1 | BCP33033 | BDBM50478347 | DTXSID00425754 | EU-0101161 | CCG-205235 | GTPL1431 | s2645 | MLS000860049 | L000560 | SIB1757 | SIB-1757 | SIB-1757; SIB1757 | AKOS024456470 | NCGC00025047-03 | SCHEMBL179770 |

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

SIB-1757 is a highly selective and noncompetitive antagonist of mGlu5 receptor with an IC50 of 0.4 μM。

Specifications

Sinonimi

NCGC00185991-01 | CHEBI:93722 | SR-01000076142-1 | BCP33033 | BDBM50478347 | DTXSID00425754 | EU-0101161 | CCG-205235 | GTPL1431 | s2645 | MLS000860049 | L000560 | SIB1757 | SIB-1757 | SIB-1757; SIB1757 | AKOS024456470 | NCGC00025047-03 | SCHEMBL179770 |

Specifiche e purezza

Moligand™, ≥98%

Meccanismi biochimici e fisiologici

A highly selective antagonist for the mGlu5metabotropic glutamate receptor subtype; displays an IC50value of 0.4μM at hmGlu5compared with > 30μM at hmGlu1b, hmGlu2, hmGlu4, hmGlu6, hmGlu7and hmGlu8.

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

ALLOSTERIC MODULATOR

Meccanismo d'azione

Allosteric modulator of mGlu 5 receptor

Purezza

≥98%

Nomi e identificatori

• Pubchem Sid: 488195160
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488195160
• Sorrisi canonici: CC1=NC(=C(C=C1)O)N=NC2=CC=CC=C2
• IUPAC Name: 6-methyl-2-phenyldiazenylpyridin-3-ol
• InChIKey: LOCPVWIREQIGNQ-UHFFFAOYSA-N
• INCHI: 1S/C12H11N3O/c1-9-7-8-11(16)12(13-9)15-14-10-5-3-2-4-6-10/h2-8,16H,1H3
• Isomeri SMILES: CC1=NC(=C(C=C1)O)N=NC2=CC=CC=C2
• PubChem CID: 5218788
• Peso molecolare: 213.24

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Pyridines and derivatives
      • Subclass Methylpyridines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Pyridines and derivatives
• Subclass: Methylpyridines
• Intermediate Tree Nodes: Not available
• Direct Parent: Methylpyridines
• Alternative Parents: Hydroxypyridines Benzene and substituted derivatives Heteroaromatic compounds Azo compounds Propargyl-type 1,3-dipolar organic compounds Azacyclic compounds Organooxygen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Methylpyridine - Hydroxypyridine - Benzenoid - Monocyclic benzene moiety - Heteroaromatic compound - Azo compound - Azacycle - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organic nitrogen compound - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aromatic heteromonocyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as methylpyridines. These are organic compounds containing a pyridine ring substituted at one or more positions by a methyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

GRM5 Tchem Metabotropic glutamate receptor 5 (0 Activities)

Discover Target: GRM5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Proprietà chimiche e fisiche

• Solubilità: Solvent:DMSO, Max Conc. mg/mL: None, Max Conc. mM: 100
• Peso molecolare: 213.230 g/mol
• XLogP3: 3.000
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 213.09 Da
• Monoisotopic Mass: 213.09 Da
• Topological Polar Surface Area: 57.800 Ų
• Heavy Atom Count: 16
• Formal Charge: 0
• Complexity: 238.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Domande frequenti

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 31993-01-8, the molecular formula is C??H??N?O, and the molecular weight is 213.24 g/mol. InChIKey LOCPVWIREQIGNQ-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.