STAMBP-IN-1 - ≥98% , CAS No.896683-78-6

CAS: 896683-78-6 Cat. No.: S649155 Formula: C₂₇H₂₈N₄O₄S Peso molecolare: 504.60

QUALITÀ & PUREZZA ≥98%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Panoramica

STAMBP-IN-1 is a small-molecule inhibitor of STAMBP deubiquitinase , and interrupts STAMBP-Ub-NALP7 interaction. STAMBP-IN-1 decreases protein level of its inflammasome substrate NALP7 and suppresses IL-1b release after Toll-like receptor (TLR) agonism. STAMBP-IN-1 inhibits the activity of STAMBP to cleave recombinant di-Ub with an IC 50 value of 0.33 mM.

In Vitro

STAMBP-IN-1 (0.1-10 μM; 6 h) exhibits the most potent ability to selectively decrease NALP7 abundance as well as endogenous NALP7 abundance in THP-1 cells, but not NALP6. STAMBP-IN-1 (0.01-100 μM; 37 ℃; 2 h) inhibits cleavage of K63-linked di-Ub (200 nM) to mono-Ub by purified recombinant STAMBP (25 nM) in a concentration dependent manner. STAMBP-IN-1 (0.01-10 μM; 37 ℃; 60 min) blocks STAMBP mediated deubiquitination of Ub-NALP7 in vitro in a concentration-dependent manner. STAMBP-IN-1 exhibits toxicity against THP-1 cells with an IC 50 of 106 μg/mL. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: THP-1 cells Concentration: 0.01, 0.1, 1, 10, and 100 μM Incubation Time: 6 hours Result: Inhibited the activity of STAMBP to cleave recombinant di-Ub in a concentrationdependent manner with an IC 50 of 0.33 mM (0.09-1.21 mM).

Form:Solid

Specifiche

Specifiche e purezza

≥98%

Meccanismi biochimici e fisiologici

STAMBP-IN-1 is a small-molecule inhibitor of STAMBP deubiquitinase , and interrupts STAMBP-Ub-NALP7 interaction. STAMBP-IN-1 decreases protein level of its inflammasome substrate NALP7 and suppresses IL-1b release after Toll-like receptor (TLR) agonism.

Condizioni di conservazione di stoccaggio

Store at 2-8°C,Protected from light,Desiccated

Spedito in

Wet ice

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Purezza

≥98%

Nomi e identificatori

Sorrisi canonici

O=C(NCC1=CC=CO1)CSC(N2CCC3=CC=CC=C3)=NC4=C(C=C(N5CCOCC5)C=C4)C2=O

Peso molecolare

504.60

Proprietà chimiche e fisiche

• Solubilità: DMSO : 3.29 mg/mL (6.52 mM; warming and heat to 80°C)

Domande frequenti

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, protected from light, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 896683-78-6, the molecular formula is C27H28N4O4S, and the molecular weight is 504.60 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.