Trilaciclib hydrochloride - ≥99% , Cyclin-dependent kinase 4 inhibitor, CAS No.1977495-97-8, Cyclin-dependent kinase 4 inhibitor

CAS: 1977495-97-8 Cat. No.: T647984 Formula: C₂₄H₃₂Cl₂N₈O Peso molecolare: 519.47 Numero EC: 891-976-4

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Panoramica

Trilaciclib hydrochloride (G1T28 hydrochloride) is a CDK4/6 inhibitor with IC 50 s of 1 nM and 4 nM for CDK4 and CDK6 , respectively

In Vitro

Incubation with Trilaciclib hydrochloride (G1T28) for 24 hours induces a robust G 1 cell-cycle arrest (time=0). By 16 hours after Trilaciclib hydrochloride washout, cells have reentered the cell cycle and demonstrate cell-cycle kinetics similar to untreated control cells. These results demonstrate that Trilaciclib hydrochloride causes a transient, and reversible G 1 arrest. A transient Trilaciclib hydrochloride-mediated G 1 cell-cycle arrest in CDK4/6-sensitive cells decreases the in vitro toxicity of a variety of commonly used cytotoxic chemotherapy agents associated with myelosuppression. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Trilaciclib hydrochloride (G1T28) treatment results in a robust and dose-dependent suppression of proliferation in HSPCs at 12 hours, with 5-ethynyl-2′-deoxyuridine (EdU) incorporation returning near baseline levels in a dose-dependent manner by 24 hours after administration. These data demonstrate that a single oral dose of Trilaciclib hydrochloride can produce reversible cell-cycle arrest in HSPCs in a dose-dependent manner in vivo . Mice given 100 mg/kg Trilaciclib hydrochloride 30 minutes prior to etoposide treatment, exhibits only background levels of caspase-3/7 activity. These data demonstrate that Trilaciclib hydrochloride can protect the bone marrow from chemotherapy-induced apoptosis in vivo . The data demonstrate that treatment with Trilaciclib hydrochloride prior to 5-fluorouracil (5-FU) likely decreases 5-FU-induced damage by chemotherapy in HSPCs, thus accelerating blood count recovery after chemotherapy . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Cdk4/cyclin D1 1 nM (IC 50 ) cdk6/cyclin D3 4 nM (IC 50 )

Specifications

Specifiche e purezza

≥99%

Meccanismi biochimici e fisiologici

Trilaciclib hydrochloride (G1T28 hydrochloride) is a CDK4/6 inhibitor with IC 50 s of 1 nM and 4 nM for CDK4 and CDK6 , respectively.

Condizioni di conservazione di stoccaggio

Store at 2-8°C,Desiccated

Spedito in

Wet ice

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Meccanismo d'azione

Cyclin-dependent kinase 4 inhibitor

Purezza

≥99%

Nomi e identificatori

• Sorrisi canonici: O=C1C2=CC3=CN=C(NC4=CC=C(N5CCN(C)CC5)C=N4)N=C3N2C6(CCCCC6)CN1.[H]Cl.[H]Cl
• Peso molecolare: 519.47

Proprietà chimiche e fisiche

• Solubilità: H2O : 25.64 mg/mL (49.36 mM; ultrasonic and adjust pH to 2 with HCl) DMSO : 1.1 mg/mL (2.12 mM; Need ultrasonic)

Domande frequenti

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1977495-97-8, the molecular formula is C24H32Cl2N8O, and the molecular weight is 519.47 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.