U0126 - Moligand™, 10 mM in DMSO , CAS No.109511-58-2

CAS: 109511-58-2 Cat. No.: U1495270 Formula: C₁₈H₁₆N₆S₂ Peso molecolare: 380.49 PubChem CID: 3006531

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

U0126 is a potent, non-ATP competitive and selective MEK1 and MEK2 inhibitor, with IC 50 s of 72 nM and 58 nM, respectively. U0126 is an autophagy and mitophagy inhibitor .

Specifications

Specifiche e purezza

Moligand™, 10 mM in DMSO

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Nomi e identificatori

• Isomeri SMILES: C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N
• PubChem CID: 3006531
• Peso molecolare: 380.49

Riferimenti

1. Chen Xue, Zhou Xing-Yue, Lan Cai, Fu Hai-Jun, Li Zhi-Chao, Chen Meng-Yi, Wen Yong-Ping, Yu Lu, Qin Da-Lian, Wu An-Guo, Wu Jian-Ming, Zhou Xiao-Gang.  (2025)  Araloside A Induces Raf/MEK/ERK-Dependent Autophagy to Mitigate Alzheimer’s and Parkinson’s Pathology in Cellular and C. elegans Models.  MOLECULAR NEUROBIOLOGY,      [PMID:40742404] [10.1007/s12035-025-05242-4]

2. Tianyi Yang, Yan Chen, Maolin Wang, Ren Ren, Fang Yan, Peng Xu, Bin Di.  (2025)  Multi-omics analysis reveals miR-7220-5p alleviates N2O addictive behaviors via NR2B/ERK/CREB signaling.  JOURNAL OF NEUROSCIENCE,      [PMID:40675813] [10.1523/JNEUROSCI.1410-24.2025]

3. Zhou Jin, Ding Yuanyuan, Zhang Yongqiang, Zheng Dehui, Yan Lifeng, Guo Mengxiang, Mao Yani, Yang Lihong.  (2022)  Exosomes from bone marrow-derived mesenchymal stem cells facilitate corneal wound healing via regulating the p44/42 MAPK pathway.  GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,  261  (3): (723-734).  [PMID:36576571] [10.1007/s00417-022-05956-4]

4. Shixuan Cui, Yang Yu, Tingjie Zhan, Yuchen Gao, Jiachen Zhang, Liang Zhang, Zhiwei Ge, Weiping Liu, Chunlong Zhang, Shulin Zhuang.  (2021)  Carcinogenic Risk of 2,6-Di-tert-Butylphenol and Its Quinone Metabolite 2,6-DTBQ Through Their Interruption of RARβ: In Vivo, In Vitro, and In Silico Investigations.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,      [PMID:34927421] [10.1021/acs.est.1c06866]

5. Aonan Xia, Yang Jiang, Yuan-Kun Lee, Dong Liang, Bo Yang, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Wei Chen.  (2024)  Identification and validation of fermented milk-derived osteogenic peptides via molecular docking and osteoblastic cell model.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2024.103698]

6. Shuli Fan, Xiang Gao, Peng Chen, Xu Li.  (2018)  Myricetin ameliorates glucocorticoid-induced osteoporosis through the ERK signaling pathway.  LIFE SCIENCES,      [PMID:29883721] [10.1016/j.lfs.2018.06.006]

Domande frequenti

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 109511-58-2, the molecular formula is C18H16N6S2, and the molecular weight is 380.49 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.