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WEE1-IN-5 - ≥99% , CAS No.2243882-74-6
AVAILABLE TO ORDER
GRADE & PURITY ≥99%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade
≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
WEE1-IN-5 is a potent WEE1 inhibitor with an IC 50 value of 0.8 nM. WEE1-IN-5 inhibits phospho-CDC2. WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. WEE1-IN-5 can be used for researching anticancer
In Vitro
WEE1-IN-5 exhibits an EC 50 of 188 nM in pCDC2 and an IC 50 shift for CYP3A4/5. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
WEE1-IN-5 (5mg/kg for PO; 1 mg/kg for IV; single dosage) exhibits a CL of 14 mL/min/kg, an AUC int 1324 h·ng/mL and bioavailability of 35% in SD rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:IC 50 : 0.8 nM (WEE1), 188 nM (CDC2)
Specifications
Specifications & Purity
≥99%
Biochemical and Physiological Mechanisms
WEE1-IN-5 is a potent WEE1 inhibitor with an IC 50 value of 0.8 nM. WEE1-IN-5 inhibits phospho-CDC2. WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. WEE1-IN-5 can be used for researching anticancer [
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥99%
Names and Identifiers
| Canonical Smiles | O=C1C2=CN=C(NC3=CC=C(C4CCN(CC4)C)C(C)=C3)N=C2N(CN1C5=C(Cl)C=CC=C5Cl)C |
|---|---|
| Molecular Weight | 511.45 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
| Solubility | DMSO : 20 mg/mL (39.10 mM; ultrasonic and warming and heat to 60°C) |
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Solution Calculators
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