X5050 - ≥98% , CAS No.2404756-81-4

CAS: 2404756-81-4 Cat. No.: X651956 Formula: C₁₇H₁₅N₃O₃ Peso molecolare: 309.32 PubChem CID: 146301742

QUALITÀ & PUREZZA ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

X5050 is a REST inhibitor, with an EC 50 of 2.1 μM.

In Vitro

X5050 (100 µM, 1 day) induces a dosedependent decrease in the REST isoform in protein level. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: NSCs. Concentration: 100 µM. Incubation Time: One day. Result: Induced a dosedependent decrease in the 122 kDa longer REST isoform.

In Vivo

X5050 (2 x 2µl of 20 mM) is active in HD pathological context . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 12-week-old male C57Bl6 mice .2 Dosage: 2 x 2µl of 20 mM in 10% DMSO in water. Administration: Intraventricular injection. Result: Increased BDNF expression. A decrease in Darpp32 and Snap25 expression was found by QRT-PCR in the lesioned striatum as compared with the contralateral striatum. Significantly increased the levels of Bdnf II splice variant (exon II containing variant) while Bdnf IV levels were not significantly changed.

Form:Solid

Specifiche

Specifiche e purezza

≥98%

Meccanismi biochimici e fisiologici

X5050 is a REST inhibitor, with an EC 50 of 2.1 μM.

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Purezza

≥98%

Nomi e identificatori

Sorrisi canonici

C=CCONC(=O)C1=CC2=C(C=C1)N=C(N2)C3=CC=CC=C3O

IUPAC Name

2-(2-hydroxyphenyl)-N-prop-2-enoxy-3H-benzimidazole-5-carboxamide

InChIKey

RGROIKJLROTDCR-UHFFFAOYSA-N

INCHI

1S/C17H15N3O3/c1-2-9-23-20-17(22)11-7-8-13-14(10-11)19-16(18-13)12-5-3-4-6-15(12)21/h2-8,10,21H,1,9H2,(H,18,19)(H,20,22)

PubChem CID

146301742

Peso molecolare

309.32

Proprietà chimiche e fisiche

• Solubilità: DMSO : 100 mg/mL (323.29 mM; Need ultrasonic)