PI3K/HDAC-IN-3 , CAS No.3006905-22-9
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P1426514
PI3K/HDAC-IN-3 (36) is a PI3K and HDAC dual inhibitor, with IC 50 values of 0.23 nM and 172 nM for PI3Kα and HDAC1 , respectively. PI3K/HDAC-IN-3 (36) suppresses AKT phosphorylation and increased H3 acetylation in MV4-11 cells. PI3K/HDAC-IN-3 (36) exhibits significant and dose-dependent anticancer efficacy in a MV4-11 xenograft model.
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| CAS | 3006905-22-9 |
|---|---|
| Condiciones de almacenamiento de almacenamiento | Store at -20°C |
| Enviado en | Ice chest + Ice pads |
| Product Description | PI3K/HDAC-IN-3 (36) is a PI3K and HDAC dual inhibitor, with IC 50 values of 0.23 nM and 172 nM for PI3Kα and HDAC1 , respectively. PI3K/HDAC-IN-3 (36) suppresses AKT phosphorylation and increased H3 acetylation in MV4-11 cells. PI3K/HDAC-IN-3 (36) exhibits significant and dose-dependent anticancer efficacy in a MV4-11 xenograft model. |
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