Uridine - ≥99% , CAS No.58-96-8

CAS: 58-96-8 Cat. No.: U108810 Formule: C₉H₁₂N₂O₆ Poids moléculaire: 244.20 Beilstein Registry Number: 754902 Numéro CE: 200-407-5

QUALITÉ & PURETÉ ≥99%

Synonyms

1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | d-Ribosyl uracile | HY-B1449 | MLS000069625 | URIDINE [MART.] | MFCD00006526 | 1-A-D-Ribofuranosyluracil | AI3-52690 | DS-14345 | beta-Uridine | s2029 | 1-.

Storage

A conserver entre 2 et 8°C

Shipped In

Glace humide

Vue d’ensemble

L'uridine est un nucléoside de l'uracile, spécifique de la séquence de l'ARN. L'uridine est présente dans le sang, le liquide séminal et le liquide céphalo-rachidien. L'uridine est synthétisée dans les organismes vivants par des voies de novo et de récupération.

Application：

L'uridine a été utilisée
comme composant du milieu des neurones hippocampiques pour la culture de cellules primaires de neurones hippocampiques ;
dans des expériences de sauvetage de l'uridine sur des fibroblastes embryonnaires de souris et des cellules de cancer du sein humain ;
dans des expériences de séquençage de chenilles.

Spécifications

Synonymes

1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | d-Ribosyl uracile | HY-B1449 | MLS000069625 | URIDINE [MART.] | MFCD00006526 | 1-A-D-Ribofuranosyluracil | AI3-52690 | DS-14345 | beta-Uridine | s2029 | 1-.

Spécifications et pureté

≥99%

Mécanismes biochimiques et physiologiques

Nucléoside. Composant de base de l'acide ribonucléique (ARN). Joue un rôle dans la voie de la glycolyse du galactose.

Conditions de stockage de stockage

A conserver entre 2 et 8°C

Expédié en

Glace humide

Type d'action

INHIBITOR

Note

Dans la mesure du possible, les solutions doivent être préparées et utilisées le même jour. Toutefois, si vous devez préparer des solutions de base à l'avance, nous vous recommandons de les conserver sous forme d'aliquotes dans des flacons hermétiques à -20°C. Ces aliquotes sont généralement utilisables pendant un mois. En général, ces solutions peuvent être utilisées pendant un mois. Avant utilisation, et avant d'ouvrir le flacon, nous vous recommandons de laisser votre produit s'équilibrer à température ambiante pendant au moins 1 heure. Besoin de plus de conseils sur la solubilité, l'utilisation et la manipulation ? Veuillez consulter notre page de questions fréquemment posées (FAQ) pour plus de détails.

Pureté

≥99%

Noms et identifiants

Pubchem Sid

508813331

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/508813331

Sourires canoniques

C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O

IUPAC Name

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

InChIKey

DRTQHJPVMGBUCF-XVFCMESISA-N

INCHI

1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1

Isomères SMILES

C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O

WGK Allemagne

3

Poids moléculaire

244.20

Beilstein

754902

Reaxy-Rn

4699706

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4699706&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Nucleosides, nucleotides, and analogues
    • Classe Pyrimidine nucleosides

• Kingdom: Organic compounds
• Superclass: Nucleosides, nucleotides, and analogues
• Classe: Pyrimidine nucleosides
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyrimidine nucleosides
• Alternative Parents: Glycosylamines Pentoses Pyrimidones Hydropyrimidines Tetrahydrofurans Heteroaromatic compounds Vinylogous amides Ureas Lactams Secondary alcohols Oxacyclic compounds Azacyclic compounds Primary alcohols Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Pyrimidine nucleoside - Glycosyl compound - N-glycosyl compound - Pentose monosaccharide - Pyrimidone - Hydropyrimidine - Monosaccharide - Pyrimidine - Vinylogous amide - Tetrahydrofuran - Heteroaromatic compound - Urea - Secondary alcohol - Lactam - Organoheterocyclic compound - Oxacycle - Azacycle - Hydrocarbon derivative - Organopnictogen compound - Organooxygen compound - Organonitrogen compound - Primary alcohol - Alcohol - Organic oxygen compound - Organic oxide - Organic nitrogen compound - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as pyrimidine nucleosides. These are compounds comprising a pyrimidine base attached to a ribosyl or deoxyribosyl moiety.
• External Descriptors: Ribonucleosides

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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SLC29A1 Tclin Equilibrative nucleoside transporter 1 (1711 Activities)

Discover Target: SLC29A1

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CAD Tchem Dihydroorotase (27 Activities)

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POLI Tchem DNA polymerase iota (116820 Activities)

Discover Target: POLI

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SLC28A1 Tbio Sodium/nucleoside cotransporter 1 (13 Activities)

Discover Target: SLC28A1

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SLC28A2 Tchem Sodium/nucleoside cotransporter 2 (91 Activities)

Discover Target: SLC28A2

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APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

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SLC28A3 Tchem Solute carrier family 28 member 3 (29 Activities)

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GMNN Tbio Geminin (128009 Activities)

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RAPGEF3 Tchem Rap guanine nucleotide exchange factor 3 (15528 Activities)

Discover Target: RAPGEF3

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CRBN Tclin Protein cereblon (139 Activities)

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TK Thymidine kinase (276 Activities)

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Cda Cytidine deaminase (37 Activities)

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deoA Thymidine phosphorylase (531 Activities)

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Uck1 Uridine-cytidine kinase 1 (5 Activities)

Discover Target: Uck1

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Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

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B4GALT1 Beta-1,4-galactosyltransferase 1 (61 Activities)

Discover Target: B4GALT1

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Tk2 Thymidine kinase 2 (53 Activities)

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Mus musculus (284745 Activities)

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Human immunodeficiency virus 1 (70413 Activities)

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Hepatitis C virus (23859 Activities)

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3T3-L1 (3664 Activities)

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L1210 (27553 Activities)

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RAW264.7 (28094 Activities)

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Sarcoma-180 (387 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Trpa1 Transient receptor potential cation channel subfamily A member 1 (1003 Activities)

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Perknaster fuscus (7 Activities)

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Ileum (29 Activities)

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Streptavidin (24 Activities)

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Slc29a2 Equilibrative nucleoside transporter 2 (4 Activities)

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ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

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NS1 Nonstructural protein 1 (33327 Activities)

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lgtC Alpha 1,4 galactosyltransferase (29 Activities)

Discover Target: lgtC

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Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: Soluble in water (50 mg/ml), DMSO, and methanol.
• Rotation spécifique [α]: 9 ° (C=2, H2O)
• Point de fusion (°C): 163-167°C
• Poids moléculaire: 244.200 g/mol
• XLogP3: -2.000
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 244.07 Da
• Monoisotopic Mass: 244.07 Da
• Topological Polar Surface Area: 119.000 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 370.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1