Calcein, AM - for fluorescence analysis, ≥96%(HPLC) , CAS No.148504-34-1
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SKU
C131116
Cell-permeable fluorescent dye for determining cell viability
Calcein-AM is a hydrophobic non-fluorescent probe that can permeate the plasma membrane and can be hydrolyzed to Calcein , which is an extremely fluorescent and negatively charged molecule. The probe can be used to stain living cells and has been observed to fluoresce bright green in cytoplasmic Schwann cells. Calcein-AM has been reported to be a neutral substrate for Mdr (P-glycoprotein (Pgp) and multidrug resistance protein (MRP)) and has been used in flow cytometry studies to analyze the function of P-gp and MRP. Studies suggest that Calcein-AM can be used to detect MDR mediated resistance and to be transported by PGP from the plasma membrane. Mitochondrial permeability research has utilized Calcein as a cytosolic fluorophore. Has been used as a cytosolic fluorophore in mitochondrial permeability studies to image pore transition.
A non-fluorescent, membrane permeable probe that can be hydrolyzed to a fluorescent molecule
추가 정보
| CAS | 148504-34-1 |
|---|---|
| 동의어 | AC1L916S | acetoxymethyl 2-[[2-(acetoxymethoxy)-2-oxo-ethyl]-[[3',6'-diacetoxy-7'-[[bis[2-(acetoxymethoxy)-2-oxo-ethyl]amino]methyl]-3-oxo-spiro[isobenzofuran-1,9'-xanthene]-2'-yl]methyl]amino]acetate | Tetrakis(acetoxymethyl) 2,2',2'',2'''-(((3',6'-diace |
| 사양 및 순도 | for fluorescence analysis, ≥96%(HPLC) |
| 보관 조건 | Store at -20°C,Argon charged |
| 배송 | Ice chest + Ice pads |
| Product Description | Calcein-AM is a hydrophobic non-fluorescent probe that can permeate the plasma membrane and can be hydrolyzed to Calcein , which is an extremely fluorescent and negatively charged molecule. The probe can be used to stain living cells and has been observed to fluoresce bright green in cytoplasmic Schwann cells. Calcein-AM has been reported to be a neutral substrate for Mdr (P-glycoprotein (Pgp) and multidrug resistance protein (MRP)) and has been used in flow cytometry studies to analyze the function of P-gp and MRP. Studies suggest that Calcein-AM can be used to detect MDR mediated resistance and to be transported by PGP from the plasma membrane. Mitochondrial permeability research has utilized Calcein as a cytosolic fluorophore. Has been used as a cytosolic fluorophore in mitochondrial permeability studies to image pore transition. |
| Pubchem Sid | 528776095 |
| 감도 | light sensitive;Moisture sensitive |
| Mdl 번호 | MFCD05861516 |
| EC 번호 | 200-664-3 |
| PubChem CID | 390986 |
| 분자 공식 | C46H46N2O23 |
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