MELK

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  1. MELK-8a hydrochloride
    CAS: 1922153-17-0 Formula: C25H32N6O Molecular Weight: 432.6
    10mM in Water
    ● In Stock — US Item #: M422352
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    Technical Identifiers
    IUPAC Name
    1-methyl-4-[4-[4-[3-(piperidin-4-ylmethoxy)pyridin-4-yl]pyrazol-1-yl]phenyl]piperazine
    SMILES
    CN1CCN(CC1)C2=CC=C(C=C2)N3C=C(C=N3)C4=C(C=NC=C4)OCC5CCNCC5
    InChIKey
    BLFBSGVUERKSST-UHFFFAOYSA-N
    InChI
    1S/C25H32N6O/c1-29-12-14-30(15-13-29)22-2-4-23(5-3-22)31-18-21(16-28-31)24-8-11-27-17-25(24)32-19-20-6-9-26-10-7-20/h2-5,8,11,16-18,20,26H,6-7,9-10,12show more
    Synonyms
    MELK-8a HCl
  2. OTSSP167, Inhibitor of maternal embryonic leucine zipper kinase
    CAS: 1431697-89-0 Formula: C25H28Cl2N4O2 Molecular Weight: 487.42
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Made to order · 8–12 wks Item #: O356679
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    IUPAC Name
    1-[6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]ethanone
    SMILES
    CC(=O)C1=CN=C2C=CC(=NC2=C1NC3CCC(CC3)CN(C)C)C4=CC(=C(C(=C4)Cl)O)Cl
    InChIKey
    DKZYXHCYPUVGAF-UHFFFAOYSA-N
    InChI
    1S/C25H28Cl2N4O2/c1-14(32)18-12-28-22-9-8-21(16-10-19(26)25(33)20(27)11-16)30-24(22)23(18)29-17-6-4-15(5-7-17)13-31(2)3/h8-12,15,17,33H,4-7,13H2,1-3H3show more
    Synonyms
    VY778IXU5T | 1431697-89-0 (free base) | AKOS030526527 | 1-(6-(3,5-Dichloro-4-hydroxyphenyl)-4-(((1r,4r)-4-((dimethyla...
  3. MELK-IN-1
    CAS: 2095596-44-2 PubChem CID: 137248544 Formula: C31H33N5O4 Molecular Weight: 539.62
    ◐ .Made to order · 8–12 wks Item #: M646879
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    IUPAC Name
    methyl 2-hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-5-carboxylate
    SMILES
    CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N=C(C3=CC=CC=C3)C4=C(NC5=C4C=C(C=C5)C(=O)OC)O
    InChIKey
    XIMRJNBUWJTLAL-UHFFFAOYSA-N
    InChI
    1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-19-22(31(39)40-3)9-14-26(25)33-30(28)38/h4-14,19,show more
  4. OTSSP167 hydrochloride
    CAS: 1431698-10-0 PubChem CID: 135565272 Formula: C25H29Cl3N4O2 Molecular Weight: 523.88
    ◐ .Made to order · 8–12 wks Item #: O648882
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    Technical Identifiers
    IUPAC Name
    1-[6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]ethanone;hydrochloride
    SMILES
    CC(=O)C1=CN=C2C=CC(=NC2=C1NC3CCC(CC3)CN(C)C)C4=CC(=C(C(=C4)Cl)O)Cl.Cl
    InChIKey
    XDGWHISAOWEFML-UHFFFAOYSA-N
    InChI
    1S/C25H28Cl2N4O2.ClH/c1-14(32)18-12-28-22-9-8-21(16-10-19(26)25(33)20(27)11-16)30-24(22)23(18)29-17-6-4-15(5-7-17)13-31(2)3;/h8-12,15,17,33H,4-7,13H2,show more
    Synonyms
    MFCD25562907 | OTSSP167 hydrochloride | AC-36802 | HY-15512A | OTS-167 monohydrochloride | Ethanone, 1-(6-(3,5-dichlo...
  5. JNJ-47117096 hydrochloride
    CAS: 1610536-69-0 PubChem CID: 132472238 Formula: C21H23ClN4O2 Molecular Weight: 398.89
    ◐ .Made to order · 8–12 wks Item #: J650437
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    Technical Identifiers
    IUPAC Name
    2-methoxy-4-(1H-pyrazol-4-yl)-N-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)benzamide;hydrochloride
    SMILES
    COC1=C(C=CC(=C1)C2=CNN=C2)C(=O)NC3=CC4=C(CCNCC4)C=C3.Cl
    InChIKey
    OXRWZUUCCUDKJJ-UHFFFAOYSA-N
    InChI
    1S/C21H22N4O2.ClH/c1-27-20-11-15(17-12-23-24-13-17)3-5-19(20)21(26)25-18-4-2-14-6-8-22-9-7-16(14)10-18;/h2-5,10-13,22H,6-9H2,1H3,(H,23,24)(H,25,26);1H
  6. MELK-T1
    CAS: 1610586-62-3 PubChem CID: 73442760
    ◐ .Made to order · 8–12 wks Item #: M769771
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    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    2-methoxy-4-(1H-pyrazol-4-yl)-N-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)benzamide
    SMILES
    COC1=C(C=CC(=C1)C2=CNN=C2)C(=O)NC3=CC4=C(CCNCC4)C=C3
    InChIKey
    GMZCYCKIXQZORP-UHFFFAOYSA-N
    InChI
    1S/C21H22N4O2/c1-27-20-11-15(17-12-23-24-13-17)3-5-19(20)21(26)25-18-4-2-14-6-8-22-9-7-16(14)10-18/h2-5,10-13,22H,6-9H2,1H3,(H,23,24)(H,25,26)
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R&D Use Only Products supplied for research and development use

Frequently Asked Questions

What can I find under MELK?
This listing collects compounds associated with MELK within our PI3K/Akt/mTOR area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.
What should I consider when picking a compound for MELK?
Consider the reported potency of each MELK compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.
What quality information is provided for MELK compounds?
Each MELK product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search MELK compounds by activity or structure?
Yes. Filter the MELK listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].

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