MPI-0479605 - Moligand™, 10mM in DMSO , Inhibitor of TTK protein kinase, CAS No.1246529-32-7, Inhibitor of TTK protein kinase
재고 있음
SKU
M421046
MPS1 Inhibitors
Information
MPI-0479605 MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases.
Targets
Mps1 1.8 nM
In vitro
MPI-0479605 impairs the SAC and the bipolar attachment of chromosomes to the mitotic spindle, which results in chromosome segregation defects and aneuploidy. MPI-0479605 results in a significant decrease in cell viability with GI50 ranging from 30 to 100 nM in a panel of tumor cell lines. In addition, MPI-0479605 also causes cell growth arrest and ultimately promotes cell death by apoptosis or mitotic catastrophe.
In vivo
MPI-0479605 (30 mg/kg daily or 150 mg/kg every 4 days, i.p.) shows antitumor activity in colon cancer xenograft models.
Cell Research(from reference)
Cell lines：A549, Colo205, DU-4475, DU-145, HCC827, HCT116, HT29, MDA MB 231, MiaPaCa2, NCI-H69, NCI-H460, NCI-N87, OPM2, and OVCAR-3 cells.
Concentrations：~10 μM
Incubation Time：3 or 7 days
추가 정보
| CAS | 1246529-32-7 |
|---|---|
| 집중력 | 10mM in DMSO |
| 동의어 | N6-cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine |
| 사양 및 순도 | Moligand™, 10mM in DMSO |
| 보관 조건 | Store at -80°C |
| 배송 | Dry ice packs + Cold packs |
| Product Description | Information MPI-0479605 MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases. Targets Mps1 1.8 nM In vitro MPI-0479605 impairs the SAC and the bipolar attachment of chromosomes to the mitotic spindle, which results in chromosome segregation defects and aneuploidy. MPI-0479605 results in a significant decrease in cell viability with GI50 ranging from 30 to 100 nM in a panel of tumor cell lines. In addition, MPI-0479605 also causes cell growth arrest and ultimately promotes cell death by apoptosis or mitotic catastrophe. In vivo MPI-0479605 (30 mg/kg daily or 150 mg/kg every 4 days, i.p.) shows antitumor activity in colon cancer xenograft models. Cell Research(from reference) Cell lines：A549, Colo205, DU-4475, DU-145, HCC827, HCT116, HT29, MDA MB 231, MiaPaCa2, NCI-H69, NCI-H460, NCI-N87, OPM2, and OVCAR-3 cells. Concentrations：~10 μM Incubation Time：3 or 7 days |
| Pubchem Sid | 528765555 |
| 목표 | TTK |
| PubChem CID | 46909588 |
| 분자 공식 | C22H29N7O |
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