Sangivamycin - ≥98% , CAS No.18417-89-5
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SKU
S339041
a cytotoxic purine nucleoside
Sangivamycin is a cytotoxic purine nucleoside active against human cytomegalovirus (HCMV). Sangivamycin is also a selective and potent PKC (protein kinase C) inhibitor (IC|50|= 10μM). The inhibition is competitive with respect to ATP and non-competitive with respect to histone and lipid cofactors. The phosphorylation of histone H1 protein is a mechanism by which Sangivamycin prevents the cell growth and acts as cytotoxic agent against a variety of human cancers.
Product description
Sangivamycin, a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an Ki of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers.
추가 정보
| CAS | 18417-89-5 |
|---|---|
| 동의어 | BRN 0626355 | 4-Amino-7-beta-D-ribofuranosyl-7H-pyrrolo(2,3-d)pyrimidine-5-carboxamide | 7H-Pyrrolo[2,3-d]pyrimidine-5-carboxamide, 4-amino-7-.beta.-D-ribofuranosyl- | Q27158840 | UNII-L8YQ8Z3T9T | 3nyn | L8YQ8Z3T9T | 4-Amino-7-.beta.-D-ribofuranosyl-7H-p |
| 사양 및 순도 | ≥98% |
| 보관 조건 | Store at -20°C |
| 배송 | Ice chest + Ice pads |
| Product Description | Sangivamycin is a cytotoxic purine nucleoside active against human cytomegalovirus (HCMV). Sangivamycin is also a selective and potent PKC (protein kinase C) inhibitor (IC|50|= 10μM). The inhibition is competitive with respect to ATP and non-competitive with respect to histone and lipid cofactors. The phosphorylation of histone H1 protein is a mechanism by which Sangivamycin prevents the cell growth and acts as cytotoxic agent against a variety of human cancers. Product description Sangivamycin, a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an Ki of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers. |
| Pubchem Sid | 528767255 |
| 용해성 | Soluble in cold water, and 0.1 M KOH. |
| EC 번호 | 634-052-6 |
| PubChem CID | 14978 |
| 분자 공식 | C12H15N5O5 |
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