1,1-Cyclohexanediacetic Acid Monoamide: Key FAQs

1,1-Cyclohexanediacetic acid monoamide is a cyclic diacetic acid derivative bearing a single amide functional group, widely used as a synthetic intermediate in pharmaceutical and fine-chemical research.

Chemical Name

1,1-Cyclohexanediacetic acid monoamide

SKU / Catalog Number

C101381

Functional Groups

Carboxylic acid and primary amide on a cyclohexane quaternary carbon scaffold

Primary Application

Pharmaceutical synthesis intermediate and fine-chemical building block

Supplier

Aladdin Scientific

Storage Recommendation

Store in a cool, dry, well-ventilated area away from incompatible materials; consult SDS for specifics

What Is 1,1-Cyclohexanediacetic Acid Monoamide?

1,1-Cyclohexanediacetic acid monoamide (catalog number C101381) is an organic compound derived from cyclohexane-1,1-diacetic acid in which one of the two carboxylic acid groups has been converted to a primary amide (–CONH₂). The remaining free carboxylic acid group and the rigid cyclohexane ring make this molecule a versatile bifunctional building block for organic synthesis.

The compound belongs to the broader class of cyclic diacid monoamides and is valued in synthetic chemistry for the chemoselectivity opportunities afforded by its mixed acid–amide functionality. Researchers can selectively react either the carboxylate or the amide group under appropriate conditions, enabling stepwise construction of more complex target molecules.

Physical and Chemical Properties

1,1-Cyclohexanediacetic acid monoamide is a solid organic compound at ambient temperature. Its molecular structure features a quaternary carbon at the 1-position of the cyclohexane ring, from which two acetic acid–derived chains extend: one terminating in a carboxylic acid (–COOH) and the other in a primary amide (–CONH₂).

Key physicochemical characteristics include moderate polarity arising from both functional groups, hydrogen-bond donor and acceptor capacity, and the conformational rigidity contributed by the six-membered ring. These features influence its solubility profile—it is expected to show good solubility in polar solvents such as water, methanol, and DMSO, with limited solubility in non-polar organic solvents. Researchers should consult the product SDS and certificate of analysis (CoA) supplied with each lot for precise melting point, purity, and spectral data.

Handling, Safety, and Storage

As with all laboratory reagents, appropriate personal protective equipment (PPE) should be worn when handling 1,1-cyclohexanediacetic acid monoamide. This includes chemical-resistant gloves, safety goggles, and a laboratory coat. Operations that generate dust should be conducted in a fume hood or with appropriate respiratory protection.

The compound should be stored in a tightly sealed container in a cool, dry, and well-ventilated location, away from strong oxidizers, bases, and other incompatible materials. Refer to the product Safety Data Sheet (SDS) available from Aladdin Scientific for complete hazard classification, first-aid measures, and disposal guidance. Keep the container closed when not in use to prevent moisture uptake and degradation.

Synthetic and Research Applications

The bifunctional nature of 1,1-cyclohexanediacetic acid monoamide makes it a useful intermediate in multi-step organic synthesis. The free carboxylic acid can participate in esterification, amide coupling, or decarboxylation reactions, while the primary amide can be dehydrated to a nitrile, reduced to an amine, or engaged in condensation chemistry.

In pharmaceutical research, cyclic diacid monoamide scaffolds have attracted interest as precursors to pharmacologically active compounds, including agents targeting neurological and metabolic pathways. The rigid cyclohexane core can confer desirable conformational properties to downstream drug candidates. Researchers in medicinal chemistry, process chemistry, and materials science may find this compound valuable as a chiral or prochiral building block, depending on the synthetic context.

Ordering and Quality Assurance

1,1-Cyclohexanediacetic acid monoamide is available from Aladdin Scientific under catalog number C101381. Each lot is manufactured and quality-controlled to research-grade standards; a Certificate of Analysis (CoA) confirming identity, purity, and relevant physical constants is available for every batch.

To place an order, visit the Aladdin Scientific website and search by product name or catalog number C101381. Bulk quantities and custom packaging may be available upon request—contact the Aladdin Scientific sales team for pricing and lead-time information. For technical questions regarding specification, grade, or application suitability, reach out to our technical support team.

Frequently asked questions

What is the catalog number for 1,1-cyclohexanediacetic acid monoamide at Aladdin Scientific?

The catalog number is C101381. You can search this SKU directly on the Aladdin Scientific website to access the product page, pricing, stock availability, and downloadable documents such as the SDS and CoA.

What solvents can be used to dissolve 1,1-cyclohexanediacetic acid monoamide?

Based on its polar bifunctional structure, the compound is expected to dissolve well in polar protic solvents such as water and methanol, as well as polar aprotic solvents like DMSO and DMF. Solubility in non-polar solvents such as hexane or diethyl ether is anticipated to be low. Researchers should verify solubility experimentally for their specific application conditions.

How should 1,1-cyclohexanediacetic acid monoamide be stored to maintain stability?

The compound should be stored in a tightly closed container in a cool, dry, and well-ventilated area, protected from moisture, heat, and incompatible reagents such as strong oxidizers and bases. Always consult the product SDS for lot-specific storage temperature recommendations and shelf-life guidance.

Can 1,1-cyclohexanediacetic acid monoamide be used as a pharmaceutical intermediate?

Yes, cyclic diacid monoamide scaffolds of this type are used in pharmaceutical synthesis as building blocks for the preparation of more complex drug candidates. The compound's mixed acid–amide functionality allows selective chemical transformations at either group. Researchers should evaluate its suitability for their specific synthetic route and regulatory requirements.

Is a Certificate of Analysis (CoA) available for this product?

Yes, Aladdin Scientific provides a Certificate of Analysis for each lot of C101381, confirming identity, purity, and key physical data. The CoA can typically be downloaded from the product page on the Aladdin Scientific website using the lot number printed on the product label.

References

1. Aladdin Scientific product page for 1,1-Cyclohexanediacetic acid monoamide, catalog number C101381.
2. March, J. Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, 4th ed. Wiley-Interscience, 1992. (General reference for carboxylic acid and amide chemistry.)

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.