Drebrin Mouse mAb: Key Facts, Uses & FAQs

Drebrin Mouse mAb is a monoclonal antibody raised in mouse that targets Drebrin, an actin-binding protein critically involved in dendritic spine morphology and neuronal cytoskeletal organization.

SKU / Catalog Number

Ab350356

Antibody Type

Mouse Monoclonal Antibody (mAb)

Formulation

PBS (phosphate-buffered saline) only; no carrier proteins or preservatives indicated

Clone Reference

KC-1963 (absea reference)

Target Protein

Drebrin (Developmentally Regulated Brain Protein)

Host Species

Mouse

Supplier

Aladdin Scientific

What Is Drebrin and Why Is It Studied?

Drebrin (Developmentally Regulated Brain Protein) is an actin-binding protein predominantly expressed in neurons. It plays a key role in regulating dendritic spine morphology, synaptic plasticity, and neuronal cytoskeletal dynamics. Drebrin stabilizes filamentous actin (F-actin) within dendritic spines and modulates the structural remodeling that underlies learning and memory.

Research interest in Drebrin has grown significantly because alterations in its expression or localization have been associated with neurodegenerative conditions and neurodevelopmental disorders. Studies examining Alzheimer's disease, for example, have noted changes in Drebrin levels in postsynaptic densities, making it a biomarker of interest for synaptic integrity.

Product Overview: Drebrin Mouse mAb (Ab350356)

The Drebrin Mouse mAb available from Aladdin Scientific (SKU: Ab350356) is a monoclonal antibody generated in mouse against the Drebrin target protein. It is referenced under clone KC-1963 (absea designation) and is supplied in a PBS-only formulation.

Because the antibody is formulated in PBS without additional stabilizers or carrier proteins such as BSA, researchers should take care during storage and handling to prevent activity loss through adsorption or freeze-thaw degradation. It is advisable to aliquot the antibody upon receipt and store according to the manufacturer's recommended conditions to maintain optimal performance.

Recommended Applications and Usage Guidance

Monoclonal antibodies raised against Drebrin are widely employed in neuroscience research workflows. Typical applications for anti-Drebrin monoclonal antibodies include Western blotting (WB) for detecting Drebrin in cell or tissue lysates, immunofluorescence (IF) or immunocytochemistry (ICC) for visualizing Drebrin distribution in cultured neurons or brain sections, and immunohistochemistry (IHC) for tissue-level localization studies.

Note: Specific validated applications, recommended dilutions, and compatible species reactivity for Ab350356 are not fully detailed in the current source material. Researchers should consult the product datasheet available on the Aladdin Scientific website or contact technical support to confirm suitability for their specific experimental system before use.

Storage, Handling, and Stability

As this antibody is supplied in PBS only, without glycerol, BSA, or sodium azide, stability considerations are especially important. General best practices for PBS-formulated monoclonal antibodies include:

• Store at –20 °C for long-term storage; avoid repeated freeze-thaw cycles by preparing single-use aliquots.
• For short-term use (up to 1–2 weeks), the antibody may be stored at 4 °C.
• Do not store at room temperature for extended periods.
• Centrifuge briefly before opening to consolidate contents.

Disclaimer: Exact stability data and shelf-life figures for Ab350356 are not provided in the current source material. Refer to the official product datasheet or contact Aladdin Scientific technical support for confirmed storage recommendations.

Ordering and Customer Support

Drebrin Mouse mAb (Ab350356) can be ordered directly through Aladdin Scientific. When placing an order, please reference the catalog number Ab350356 to ensure accurate fulfillment. For bulk or custom quantities, institutional pricing, or questions regarding availability and lead times, contact the Aladdin Scientific sales or customer service team.

For technical questions regarding experimental protocols, troubleshooting, or application compatibility, Aladdin Scientific's technical support team is available to assist. Researchers are encouraged to request the full product datasheet, which contains validated application data, lot-specific quality control information, and recommended dilution ranges.

Frequently asked questions

What is the catalog number for Drebrin Mouse mAb at Aladdin Scientific?

The catalog number for Drebrin Mouse mAb at Aladdin Scientific is Ab350356. When ordering, please quote this SKU to ensure you receive the correct product.

What formulation is Drebrin Mouse mAb (Ab350356) supplied in?

Ab350356 is supplied in PBS (phosphate-buffered saline) only. It does not contain additional carrier proteins such as BSA or preservatives such as sodium azide based on the available product information. Researchers should aliquot and store accordingly to preserve antibody activity.

What is Drebrin and why is it a relevant research target?

Drebrin is a developmentally regulated actin-binding protein predominantly expressed in neurons. It is involved in regulating dendritic spine morphology and synaptic plasticity, making it relevant to studies of neuronal development, learning and memory, and neurodegenerative diseases such as Alzheimer's disease.

Which experimental applications is the Drebrin Mouse mAb suitable for?

Anti-Drebrin monoclonal antibodies are commonly used in Western blotting, immunofluorescence, immunocytochemistry, and immunohistochemistry. However, specific validated applications and recommended dilutions for Ab350356 are not confirmed in the current source material; please consult the product datasheet or contact Aladdin Scientific technical support for verified application data.

How should I store Drebrin Mouse mAb (Ab350356) to maintain its activity?

As a PBS-only formulated antibody, it is generally recommended to aliquot the product upon receipt and store long-term at –20 °C to avoid repeated freeze-thaw cycles. For short-term use, storage at 4 °C is typically acceptable. Always refer to the official product datasheet for lot-specific storage instructions.

Is Drebrin Mouse mAb (Ab350356) available for bulk or custom orders?

For information on bulk quantities, custom formulations, or institutional pricing for Ab350356, please contact Aladdin Scientific's sales or customer service team directly. They can advise on availability, lead times, and pricing options tailored to your laboratory's needs.

References

1. Drebrin product reference: absea clone KC-1963, PBS formulation. Aladdin Scientific catalog Ab350356.
2. Shirao T, Gonzalez-Billault C. Actin filaments and microtubules in dendritic spines. J Neurochem. 2013. [General background on Drebrin function — specific citation details require verification.]

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.