Ethyl 2-Morpholinecarboxylate Hydrochloride: FAQs

Ethyl 2-Morpholinecarboxylate Hydrochloride is a morpholine-derived heterocyclic building block widely employed as a synthetic intermediate in medicinal chemistry and organic synthesis research.

Product Name

Ethyl 2-Morpholinecarboxylate Hydrochloride

SKU

E733336

Compound Class

Morpholine heterocycle, hydrochloride salt

Primary Application

Synthetic intermediate and building block in organic and medicinal chemistry

Physical Form

Solid (hydrochloride salt form)

Storage Recommendation

Store in a cool, dry place away from moisture and light; consult SDS for detailed conditions

What Is Ethyl 2-Morpholinecarboxylate Hydrochloride?

Ethyl 2-Morpholinecarboxylate Hydrochloride (SKU: E733336) is the hydrochloride salt of the ethyl ester of morpholine-2-carboxylic acid. Morpholine is a six-membered heterocyclic ring containing one nitrogen and one oxygen atom, making it a privileged scaffold in pharmaceutical and agrochemical research. The carboxylate ester functionality at the 2-position provides a reactive handle for further chemical elaboration, including hydrolysis to the free acid, amide coupling, or reduction reactions. The hydrochloride salt form improves stability and handling properties relative to the free base.

Handling, Safety, and Storage

As with all laboratory reagents, standard personal protective equipment (PPE) — including gloves, safety goggles, and a laboratory coat — should be worn when handling Ethyl 2-Morpholinecarboxylate Hydrochloride. The compound is supplied as a solid salt, which generally presents lower inhalation risk than volatile liquids, but care should be taken to avoid generating dust. Always consult the Safety Data Sheet (SDS) provided by Aladdin Scientific for specific hazard classifications, first-aid measures, and disposal requirements before use.

For storage, keep the reagent tightly sealed in a cool, dry environment away from moisture, heat sources, and direct light. Hydrochloride salts can be hygroscopic; exposure to atmospheric moisture may affect purity and reactivity. It is advisable to store the material under inert atmosphere or with desiccant if long-term stability is required.

Applications in Synthesis and Research

Ethyl 2-Morpholinecarboxylate Hydrochloride serves as a versatile building block in organic synthesis. Its morpholine ring is frequently incorporated into drug candidates due to the ring's ability to improve aqueous solubility, metabolic stability, and pharmacokinetic profiles. The ester group at the 2-position can be selectively transformed under mild conditions, allowing researchers to diversify the scaffold efficiently.

Typical synthetic uses include: (1) preparation of morpholine-2-carboxamides via aminolysis; (2) reduction to the corresponding amino alcohol; (3) hydrolysis to morpholine-2-carboxylic acid for peptide-coupling strategies; and (4) incorporation into heterocyclic libraries for high-throughput screening campaigns. Researchers in medicinal chemistry, combinatorial chemistry, and agrochemical development may find this compound particularly useful.

Ordering and Product Availability

Ethyl 2-Morpholinecarboxylate Hydrochloride is available from Aladdin Scientific under SKU E733336. To place an order, visit the Aladdin Scientific website, search by product name or SKU, and add the desired quantity to your cart. For bulk quantities, custom packaging, or institutional procurement inquiries, please contact Aladdin Scientific's sales team directly.

Availability and pack sizes may vary by region. Registered account holders can access order history, track shipments, and apply reward points or promotional coupons at checkout. For questions about pricing, delivery timelines, or returns, consult the Help and Customer Service section of the Aladdin Scientific website or reach out to customer support.

Frequently asked questions

What is the CAS number of Ethyl 2-Morpholinecarboxylate Hydrochloride?

The CAS number for Ethyl 2-Morpholinecarboxylate Hydrochloride is not explicitly stated in the current source material. Please refer to the product page for SKU E733336 on the Aladdin Scientific website or the accompanying Certificate of Analysis (CoA) for the confirmed CAS number.

How should I store Ethyl 2-Morpholinecarboxylate Hydrochloride to maintain its stability?

Store the compound in a tightly sealed container in a cool, dry location away from moisture, light, and heat. Because hydrochloride salts can be hygroscopic, consider using a desiccant or storing the material under an inert atmosphere such as nitrogen or argon for long-term use. Always refer to the SDS for compound-specific storage guidance.

What are the main synthetic applications of Ethyl 2-Morpholinecarboxylate Hydrochloride?

This compound is primarily used as a heterocyclic building block in medicinal chemistry and organic synthesis. Key applications include the preparation of morpholine-2-carboxamides, reduction to amino alcohols, hydrolysis to the parent carboxylic acid for peptide coupling, and incorporation into compound libraries for drug discovery screening programs.

Is a Certificate of Analysis (CoA) available for Ethyl 2-Morpholinecarboxylate Hydrochloride?

Yes, Aladdin Scientific provides a Certificate of Analysis for its research reagents. You can request or download the CoA for SKU E733336 through the product page on the Aladdin Scientific website or by contacting customer support with your lot number.

Can I return Ethyl 2-Morpholinecarboxylate Hydrochloride if there is a quality issue?

Aladdin Scientific has a returns and refunds policy to address quality concerns. If you believe there is a quality issue with your order of SKU E733336, please contact Aladdin Scientific customer service promptly with your order details and lot number. Refer to the Returns and Refunds section of the website for full policy details.

References

1. Aladdin Scientific product page: Ethyl 2-Morpholinecarboxylate Hydrochloride, SKU E733336.
2. March, J. Advanced Organic Chemistry: Reactions, Mechanisms, and Structure. Wiley-Interscience. (General reference for ester reactivity and heterocyclic chemistry.)
3. Meanwell, N. A. Synopsis of some recent tactical application of bioisosteres in drug design. Journal of Medicinal Chemistry. (General reference for morpholine as a privileged scaffold in drug discovery.)

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.