USP8-IN-3 - ≥99% , CAS No.2477651-10-6

CAS: 2477651-10-6 Cat. No.: U648417 Fórmula: C₁₈H₁₈F₃N₅O₂S Peso molecular: 425.43

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

USP8-IN-3 (Compd U51) is a deubiquitinase USP8 inhibitor with an IC 50 value of 4.0 μM. USP8-IN-3 also inhibits the proliferation of GH3 and H1957 cells with GI 50 s of 37.03 μM and 6.01 μM, respectively

In Vitro

USP8-IN-3 (6.25-100 μM; 15 min) inhibits the cleavage activity of USP8 on diubiquitin. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: / Concentration: 6.25 μM, 12.5 μM, 25 μM, 50 μM, and 100 μM Incubation Time: 15 min; added Di-Ub substrate for another 1 h Result: Decreased the cleaved diubiquitin level.

Form:Solid

IC50& Target:USP8 4.0 μM (IC 50 )

Specifications

Especificações e pureza

≥99%

Mecanismos bioquímicos e fisiológicos

USP8-IN-3 (Compd U51) is a deubiquitinase USP8 inhibitor with an IC 50 value of 4.0 μM. USP8-IN-3 also inhibits the proliferation of GH3 and H1957 cells with GI 50 s of 37.03 μM and 6.01 μM, respectively.

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥99%

Nomes e identificadores

• Sorrisos canónicos: [O-][N+](C1=CC=C(NC(NC2CCN(CC2)C3=CC=CC(C(F)(F)F)=N3)=S)C=C1)=O
• Peso molecular: 425.43

Propriedades químicas e físicas

• Solubilidade: DMSO : 100 mg/mL (235.06 mM; Need ultrasonic)

Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2477651-10-6, the molecular formula is C18H18F3N5O2S, and the molecular weight is 425.43 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.