Ciclo celular/danos no ADN

Explore pequenas moléculas relacionadas com o controlo do ciclo celular e as vias de danos no ADN para investigação oncológica, estudos sobre pontos de controlo e desenvolvimento de ensaios. Utilize esta categoria para comparar compostos relevantes para o controlo da proliferação, mecanismos de reparação e sinalização da resposta ao stress.

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  1. Iisoindigotin
    CAS: 476-34-6 Fórmula: C16H10N2O2 Peso molecular: 262.26
    Sólido Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Sob encomenda · 8–12 semanas Item #: I303788
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    Nome IUPAC
    3-(2-hydroxy-1H-indol-3-yl)indol-2-one
    SMILES
    C1=CC=C2C(=C1)C(=C(N2)O)C3=C4C=CC=CC4=NC3=O
    InChIKey
    VBMISAYWIMDRCV-UHFFFAOYSA-N
    InChI
    1S/C16H10N2O2/c19-15-13(9-5-1-3-7-11(9)17-15)14-10-6-2-4-8-12(10)18-16(14)20/h1-8,17,19H
    Sinónimos
    SR-01000390554 | (3E)-3-(2-oxo-1H-indol-3-ylidene)-1H-indol-2-one | 3-(2-hydroxy-1H-indol-3-yl)indol-2-one | SCHEMBL1...
  2. GSK2850163
    CAS: 2121989-91-9 PubChem CID: 73291790 Fórmula: C24H29Cl2N3O Peso molecular: 446.41
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Sob encomenda · 8–12 semanas Item #: G650135
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    Nome IUPAC
    (5R)-2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-2,7-diazaspiro[4.5]decane-7-carboxamide
    SMILES
    CC1=CC=C(C=C1)CNC(=O)N2CCCC3(C2)CCN(C3)CC4=CC(=C(C=C4)Cl)Cl
    InChIKey
    YFDASBFQKMHSSJ-XMMPIXPASA-N
    InChI
    1S/C24H29Cl2N3O/c1-18-3-5-19(6-4-18)14-27-23(30)29-11-2-9-24(17-29)10-12-28(16-24)15-20-7-8-21(25)22(26)13-20/h3-8,13H,2,9-12,14-17H2,1H3,(H,27,30)/t2show more
    Sinónimos
    (R)-2-(3,4-Dichlorobenzyl)-N-(4-methylbenzyl)-2,7-diazaspiro[4.5]decane-7-carboxamide | Gsk2850163
  3. Ceramides Mixture
    CAS: 100403-19-8 Número CE: 309-560-3 PubChem CID: 74945544
    Sólido ≥95%
    ● Em estoque — EUA Item #: C647629
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    Nome IUPAC
    N-(1,3,4-trihydroxyoctadecan-2-yl)octadec-9-enamide
    SMILES
    CCCCCCCCCCCCCCC(C(C(CO)NC(=O)CCCCCCCC=CCCCCCCCC)O)O
    InChIKey
    ATGQXSBKTQANOH-UHFFFAOYSA-N
    InChI
    1S/C36H71NO4/c1-3-5-7-9-11-13-15-17-18-19-21-23-25-27-29-31-35(40)37-33(32-38)36(41)34(39)30-28-26-24-22-20-16-14-12-10-8-6-4-2/h17-18,33-34,36,38-39,show more
    Sinónimos
    Ceramide 3 | SY343426 | N-[(2S,3S,4R)-1,3,4-Trihydroxy-2-octadecyl]oleamide | FT-0623551
  4. DAPI Staining Solution
    Líquido Sterile-filtered ? Sterile-filtered — passed through a 0.2µm filter to remove microorganisms. Use as a ready aseptic solution for culture and sensitive applications. BioReagent ? BioReagent grade — tested suitable for life-science and molecular-biology use. Use for cell culture, assays, and biochemical work needing biological compatibility. for Microscopy ? Microscopy grade — reagents/stains suited to sample prep and imaging. Use in microscopy where clarity and low background are needed. Suitable for Immunofluorescence(IF) ? IF grade — validated for immunofluorescence with low background staining. Use to localize targets in cells/tissue by fluorescence microscopy. 1.0 mg/mL
    ● Em estoque — EUA Item #: D1372407
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    Sinónimos
    DAPI | DAPI Staining Solution | DAPI Reagent | DAPI Stain | DAPI Solution
  5. Hoechst 33342 Staining Solution
    CAS: 23491-52-3 Número CE: 245-691-1 Fórmula: C27H28N6O • 3HCl • xH2O Peso molecular: 561.93(anhydrous basis)
    Líquido BioReagent ? BioReagent grade — tested suitable for life-science and molecular-biology use. Use for cell culture, assays, and biochemical work needing biological compatibility. Ready-to-use ? Ready-to-use — supplied pre-formulated at working concentration, no prep needed. Use to save time and reduce pipetting/dilution errors. Biological Stain ? Biological stain grade — dyes characterized for staining cells and tissues. Use in histology and microscopy where staining consistency matters. for Fluorescence analysis ? Fluorescence-analysis grade — very low fluorescent impurities for clean spectra. Use in fluorescence assays where background interferes. Biological dye grade ? Biological stain grade — dyes characterized for staining cells and tissues. Use in histology and microscopy where staining consistency matters. for Microscopy ? Microscopy grade — reagents/stains suited to sample prep and imaging. Use in microscopy where clarity and low background are needed. for Cell culture ? Cell-culture grade — low endotoxin and contaminants to support viable cell growth. Use in mammalian/other cell culture media and supplements. Suitable for Immunofluorescence(IF) ? IF grade — validated for immunofluorescence with low background staining. Use to localize targets in cells/tissue by fluorescence microscopy. 1.0 mg/ml in H₂O
    ● Em estoque — EUA Item #: O1501802
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    Sinónimos
    Hoechst 33342 Stain Solution (1 mg/mL) | Hoechst 33342 Staining Solution for Live Cells, 100X | Hoechst 33342 Solution
  6. Hoechst 33258 staining solution
    CAS: 23491-45-4 Número CE: 245-690-6 PubChem CID: 31953 Fórmula: C25H24N6O·3HCl Peso molecular: 533.90
    Líquido BioReagent ? BioReagent grade — tested suitable for life-science and molecular-biology use. Use for cell culture, assays, and biochemical work needing biological compatibility. Ready-to-use ? Ready-to-use — supplied pre-formulated at working concentration, no prep needed. Use to save time and reduce pipetting/dilution errors. Biological Stain ? Biological stain grade — dyes characterized for staining cells and tissues. Use in histology and microscopy where staining consistency matters. for Fluorescence analysis ? Fluorescence-analysis grade — very low fluorescent impurities for clean spectra. Use in fluorescence assays where background interferes. Biological dye grade ? Biological stain grade — dyes characterized for staining cells and tissues. Use in histology and microscopy where staining consistency matters. for Microscopy ? Microscopy grade — reagents/stains suited to sample prep and imaging. Use in microscopy where clarity and low background are needed. for Cell culture ? Cell-culture grade — low endotoxin and contaminants to support viable cell growth. Use in mammalian/other cell culture media and supplements. Suitable for Immunofluorescence(IF) ? IF grade — validated for immunofluorescence with low background staining. Use to localize targets in cells/tissue by fluorescence microscopy. 1.0 mg/mL in H₂O
    ● Em estoque — EUA Item #: H1373484
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    Sinónimos
    Hoechst 33258 | Hoechst 33258 Stain Solution | Hoechst 33258 Stain Solution(1mg/ml) | Hoechst 33258 Staining Dye Solu...
  7. Sertaconazole nitrate, Cytochrome P450 51 inhibitor
    CAS: 99592-39-9 PubChem CID: 200103 Fórmula: C20H15Cl3N2OS·HNO3 Peso molecular: 500.78
    ● Em estoque — EUA Item #: S129395
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    Nome IUPAC
    1-[2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole;nitric acid
    SMILES
    C1=CC2=C(C(=C1)Cl)SC=C2COC(CN3C=CN=C3)C4=C(C=C(C=C4)Cl)Cl.[N+](=O)(O)[O-]
    InChIKey
    HAAITRDZHUANGT-UHFFFAOYSA-N
    InChI
    1S/C20H15Cl3N2OS.HNO3/c21-14-4-5-16(18(23)8-14)19(9-25-7-6-24-12-25)26-10-13-11-27-20-15(13)2-1-3-17(20)22;2-1(3)4/h1-8,11-12,19H,9-10H2;(H,2,3,4)
    Sinónimos
    HMS1571A12 | CAS-99592-39-9 | A851341 | 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H...
  8. GW 1929 hydrochloride
    CAS: 1217466-21-1 PubChem CID: 56972174 Fórmula: C30H29N3O4•HCl Peso molecular: 532.03
    ◐ .Sob encomenda · 8–12 semanas Item #: G286659
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    Nome IUPAC
    (2S)-2-(2-benzoylanilino)-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]propanoic acid;hydrochloride
    SMILES
    CN(CCOC1=CC=C(C=C1)CC(C(=O)O)NC2=CC=CC=C2C(=O)C3=CC=CC=C3)C4=CC=CC=N4.Cl
    InChIKey
    KXNKIKXTGRMLEY-YCBFMBTMSA-N
    InChI
    1S/C30H29N3O4.ClH/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23;/h2-18,27,32H,19-show more
    Sinónimos
    N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine hydrochloride
  9. Lumbrokinase
    CAS: 556743-18-1
    Sólido EnzymoPure™ ? EnzymoPure™ — Aladdin's line of high-quality enzymatic solutions. Use when enzyme purity and defined activity drive assay or process performance. ≥12000U/mg
    ● Em estoque — EUA Item #: L115121
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    Identificadores técnicos
    Espécie
    Earthworm
    Bioatividade
    ≥12000U/mg
  10. NCH 51
    CAS: 848354-66-5 Fórmula: C20H26N2O2S2 Peso molecular: 390.57
    ● Em estoque — EUA Item #: N274711
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    Nome IUPAC
    S-[7-oxo-7-[(4-phenyl-1,3-thiazol-2-yl)amino]heptyl] 2-methylpropanethioate
    SMILES
    CC(C)C(=O)SCCCCCCC(=O)NC1=NC(=CS1)C2=CC=CC=C2
    InChIKey
    MDYDGUOQFUQOGE-UHFFFAOYSA-N
    InChI
    1S/C20H26N2O2S2/c1-15(2)19(24)25-13-9-4-3-8-12-18(23)22-20-21-17(14-26-20)16-10-6-5-7-11-16/h5-7,10-11,14-15H,3-4,8-9,12-13H2,1-2H3,(H,21,22,23)
    Sinónimos
    S-[7-oxo-7-[(4-phenyl-1,3-thiazol-2-yl)amino]heptyl] 2-methylpropanethioate | dibenzo[b,d]furan-4-yl boronic acid | N...
  11. Retaspimycin
    CAS: 857402-23-4 Fórmula: C31H45N3O8 Peso molecular: 587.7
    ◐ .Sob encomenda · 8–12 semanas Item #: R127859
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    Nome IUPAC
    [(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13,20,22-trihydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3-oxo-19-(prop-2-enylamino)-2-azabicyclo[16.3.1]docosa-1(show more
    SMILES
    CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=C(C(=C2O)C1)NCC=C)O)C)OC)OC(=O)N)C)C)O)OC
    InChIKey
    OAKGNIRUXAZDQF-TXHRRWQRSA-N
    InChI
    1S/C31H45N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,show more
    Sinónimos
    D09375 | IPI-504 | (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13,20,22-Trihydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3-oxo-...
  12. Retinoic acid
    CAS: 302-79-4 Número CE: 206-129-0 Fórmula: C20H28O2 Peso molecular: 300.44
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● Em estoque — EUA Item #: R106320
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    Nome IUPAC
    (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
    SMILES
    CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
    InChIKey
    SHGAZHPCJJPHSC-YCNIQYBTSA-N
    InChI
    1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
    Sinónimos
    (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid | TRETINOIN COMPONENT OF...
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Perguntas frequentes

What should I compare when selecting Cell Cycle/DNA Damage?
Within Cell Cycle/DNA Damage, compare source and expression system, purity and the method used to measure it, specific activity, and buffer composition. In a sensitive assay the buffer can matter as much as the protein itself.
Which Cell Cycle/DNA Damage subcategory should I start with?
Cell Cycle/DNA Damage is organised into Antifolate, APC, ATF6, ATM/ATR and Aurora Kinase, and 48 further subcategories. Choose by the workflow step you are at rather than by molecule type — most workflows draw from more than one subcategory.
Which quality data should I review before ordering Cell Cycle/DNA Damage?
Review the lot-specific Certificate of Analysis for the Cell Cycle/DNA Damage product — purity, activity, and endotoxin — and confirm the buffer and any carrier protein. Carrier-free formats are worth specifying where downstream labelling or conjugation is planned. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What documentation is available for Cell Cycle/DNA Damage?
Each Cell Cycle/DNA Damage product page links a datasheet and a lot-specific Certificate of Analysis covering purity, activity, and storage. For lot reservations, bulk quantities, or documentation not shown, contact [email protected].

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