X5050 - ≥98% , CAS No.2404756-81-4

CAS: 2404756-81-4 Cat. No.: X651956 Fórmula: C₁₇H₁₅N₃O₃ Peso molecular: 309.32 PubChem CID: 146301742

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

X5050 is a REST inhibitor, with an EC 50 of 2.1 μM.

In Vitro

X5050 (100 µM, 1 day) induces a dosedependent decrease in the REST isoform in protein level. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: NSCs. Concentration: 100 µM. Incubation Time: One day. Result: Induced a dosedependent decrease in the 122 kDa longer REST isoform.

In Vivo

X5050 (2 x 2µl of 20 mM) is active in HD pathological context . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 12-week-old male C57Bl6 mice .2 Dosage: 2 x 2µl of 20 mM in 10% DMSO in water. Administration: Intraventricular injection. Result: Increased BDNF expression. A decrease in Darpp32 and Snap25 expression was found by QRT-PCR in the lesioned striatum as compared with the contralateral striatum. Significantly increased the levels of Bdnf II splice variant (exon II containing variant) while Bdnf IV levels were not significantly changed.

Form:Solid

Specifications

Especificações e pureza

≥98%

Mecanismos bioquímicos e fisiológicos

X5050 is a REST inhibitor, with an EC 50 of 2.1 μM.

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥98%

Nomes e identificadores

• Sorrisos canónicos: C=CCONC(=O)C1=CC2=C(C=C1)N=C(N2)C3=CC=CC=C3O
• IUPAC Name: 2-(2-hydroxyphenyl)-N-prop-2-enoxy-3H-benzimidazole-5-carboxamide
• InChIKey: RGROIKJLROTDCR-UHFFFAOYSA-N
• INCHI: 1S/C17H15N3O3/c1-2-9-23-20-17(22)11-7-8-13-14(10-11)19-16(18-13)12-5-3-4-6-15(12)21/h2-8,10,21H,1,9H2,(H,18,19)(H,20,22)
• PubChem CID: 146301742
• Peso molecular: 309.32

Propriedades químicas e físicas

• Solubilidade: DMSO : 100 mg/mL (323.29 mM; Need ultrasonic)