10-Methoxy-canthin-6-one - ≥98% , CAS No.86293-40-5
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SKU
M1436302
0-Methoxy-canthin-6-one (Mtx-C) is a DNA damage inducer. 0-Methoxy-canthin-6-one promotes cell cycle arrest at the G2/M phase by intercalating into DNA, thereby inducing myeloid differentiation of acute myeloid leukemia (AML) cells and leukemic stem cells (LSCs). The myeloid differentiation in AML and LSC cells is characterized by increased expression of myeloperoxidase , CD15 , CD11b , and CD14 , as well as activation of p38 MAPK. 0-Methoxy-canthin-6-one can be used in leukemia research.
More Information
| CAS | 86293-40-5 |
|---|---|
| Specifications & Purity | ≥98% |
| Storage | Store at 2-8°C |
| Shipped In | Wet ice |
| Product Description | 0-Methoxy-canthin-6-one (Mtx-C) is a DNA damage inducer. 0-Methoxy-canthin-6-one promotes cell cycle arrest at the G2/M phase by intercalating into DNA, thereby inducing myeloid differentiation of acute myeloid leukemia (AML) cells and leukemic stem cells (LSCs). The myeloid differentiation in AML and LSC cells is characterized by increased expression of myeloperoxidase , CD15 , CD11b , and CD14 , as well as activation of p38 MAPK. 0-Methoxy-canthin-6-one can be used in leukemia research. |
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