Antibody-drug Conjugates(ADC)

ADC-focused building blocks and tools to support antibody–drug conjugate research. Explore payloads, linkers, conjugation reagents, and related small-molecule components (where available) for designing and evaluating ADC constructs.

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  1. Fmoc-Val-Cit-PAB-PNP
    CAS: 863971-53-3 Formula: C40H42N6O10 Molecular Weight: 766.81
    In Stock Item #: F404474
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    IUPAC Name
    [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carshow more
    SMILES
    CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)COC(=O)OC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35
    InChIKey
    USMYACISHVPTHK-PXLJZGITSA-N
    InChI
    1S/C40H42N6O10/c1-24(2)35(45-39(50)54-23-33-31-10-5-3-8-29(31)30-9-4-6-11-32(30)33)37(48)44-34(12-7-21-42-38(41)49)36(47)43-26-15-13-25(14-16-26)22-55show more
    Synonyms
    AKOS025312193 | HY-41189 | (9H-fluoren-9-yl)methyl ((S)-3-methyl-1-(((S)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl...
  2. (S)-12-Benzyl-2,2-dimethyl-4,7,10,13-tetraoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-oic acid
    CAS: 187794-49-6 Formula: C20H28N4O7 Molecular Weight: 436.46
    Solid ≥97%
    In Stock Item #: B412456
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    IUPAC Name
    2-[[(2S)-2-[[2-[[2-[(2-methylpropan-2-yl)oxycarbonylamino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetic acid
    SMILES
    CC(C)(C)OC(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)O
    InChIKey
    PTUJJIPXBJJLLV-AWEZNQCLSA-N
    InChI
    1S/C20H28N4O7/c1-20(2,3)31-19(30)23-10-15(25)21-11-16(26)24-14(18(29)22-12-17(27)28)9-13-7-5-4-6-8-13/h4-8,14H,9-12H2,1-3H3,(H,21,25)(H,22,29)(H,23,30show more
    Synonyms
    (S)-12-Benzyl-2,2-dimethyl-4,7,10,13-tetraoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-oicacid | Glycine, N-[(1,1-dimethy...
  3. McMMAF
    CAS: 863971-19-1 EC Number: 809-632-9 PubChem CID: 56949327 Formula: C49H76N6O11 Molecular Weight: 925.2
    Out of Stock Item #: M596644
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    IUPAC Name
    (2S)-2-[[(2R,3R)-3-[(2S)-1-[(3R,4S,5S)-4-[[(2S)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoyl-methylamino]-3-methylbutanoyl]amino]-3-methylbutanoyl]-meshow more
    SMILES
    CCC(C)C(C(CC(=O)N1CCCC1C(C(C)C(=O)NC(CC2=CC=CC=C2)C(=O)O)OC)OC)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)N(C)C(=O)CCCCCN3C(=O)C=CC3=O
    InChIKey
    ORFNVPGICPYLJV-YTVPMEHESA-N
    InChI
    1S/C49H76N6O11/c1-12-32(6)44(37(65-10)29-41(59)54-27-19-22-36(54)45(66-11)33(7)46(60)50-35(49(63)64)28-34-20-15-13-16-21-34)53(9)48(62)42(30(2)3)51-47show more
    Synonyms
    FT-0615072 | Q27285195 | SCHEMBL10220875 | AC-32507 | McMMAF | MC-MMAF | MCMMA-F | N-((2R,3R)-3-((2S)-1-((3R,4S,5S)-4...
  4. sulfo-SPDB
    CAS: 1193111-39-5 PubChem CID: 53248044 Formula: C13H14N2O7S3 Molecular Weight: 406.45
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95%
    Out of Stock Item #: S651090
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    IUPAC Name
    1-(2,5-dioxopyrrolidin-1-yl)oxy-1-oxo-4-(pyridin-2-yldisulfanyl)butane-2-sulfonic acid
    SMILES
    C1CC(=O)N(C1=O)OC(=O)C(CCSSC2=CC=CC=N2)S(=O)(=O)O
    InChIKey
    FUHCFUVCWLZEDQ-UHFFFAOYSA-N
    InChI
    1S/C13H14N2O7S3/c16-11-4-5-12(17)15(11)22-13(18)9(25(19,20)21)6-8-23-24-10-3-1-2-7-14-10/h1-3,7,9H,4-6,8H2,(H,19,20,21)
    Synonyms
    1-(2,5-Dioxopyrrolidin-1-Yloxy)-1-Oxo-4-(pyridin-2-Yldisulfanyl)butane-2-Sulfonic Acid
  5. (R)-DOTA-GA(tBu)4-OH
    CAS: 817562-90-6 Formula: C35H64N4O10 Molecular Weight: 700.90
    Solid ≥97%
    Out of Stock Item #: O679292
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    SMILES
    CC(C)(C)OC(=O)CN1CCN(CCN(CCN(CC1)CC(=O)OC(C)(C)C)[C@H](CCC(=O)O)C(=O)OC(C)(C)C)CC(=O)OC(C)(C)C
    InChIKey
    SUAUFMLRKFUOID-AREMUKBSSA-N
    InChI
    1S/C35H64N4O10/c1-32(2,3)46-28(42)23-36-15-17-37(24-29(43)47-33(4,5)6)19-21-39(26(13-14-27(40)41)31(45)49-35(10,11)12)22-20-38(18-16-36)25-30(44)48-34show more
    Synonyms
    (R)-5-(tert-Butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoic aci...
  6. (S)-NODAGA-tris(t-Bu ester) ·TFA
    CAS: 438553-50-5(free base) Formula: C27H49N3O8(free base) Molecular Weight: 543.69(free base)
    Solid ≥97%
    Out of Stock Item #: T679298
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    IUPAC Name
    4-[4,7-bis[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-1,4,7-triazonan-1-yl]-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid
    SMILES
    CC(C)(C)OC(=O)CN1CCN(CCN(CC1)C(CCC(=O)O)C(=O)OC(C)(C)C)CC(=O)OC(C)(C)C
    InChIKey
    ADHGPCATMVZKLP-UHFFFAOYSA-N
    InChI
    1S/C27H49N3O8/c1-25(2,3)36-22(33)18-28-12-13-29(19-23(34)37-26(4,5)6)15-17-30(16-14-28)20(10-11-21(31)32)24(35)38-27(7,8)9/h20H,10-19H2,1-9H3,(H,31,32show more
    Synonyms
    (S)-4-(4,7-Bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7-triazonan-1-yl)-5-(tert-butoxy)-5-oxopentanoic acid | ((S)-NODAG)
  7. Fmoc-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH
    CAS: 2264011-98-3 Formula: C33H35N5O9 Molecular Weight: 645.66
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: F767878
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    (S)-11-Benzyl-1-(9H-fluoren-9-yl)-3,6,9,12,15-pentaoxo-2,18-dioxa-4,7,10,13,16-pentaazaicosan-20-oic acid
  8. Gly-Gly-Phe-Gly-NH-O-CO-Exatecan
    CAS: 1599440-12-6 Formula: C42H45FN8O10 Molecular Weight: 840.85
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95%
    In Stock Item #: G767884
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    GGFG-Dxd | (S)-2-(2-(2-Aminoacetamido)acetamido)-N-(2-(((2-(((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-...
  9. Dibromomaleimide-C5-COOH
    CAS: 1443214-97-8 Formula: C10H11Br2NO4 Molecular Weight: 369.01
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    In Stock Item #: D767933
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    Synonyms
    6-(3,4-Dibromo-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoic acid
  10. poly(butyl methacrylate)(PBMA)
    CAS: 9003-63-8 EC Number: 630-373-0 PubChem CID: 22667557 Formula: (C8H14O2)n
    Liquid Mw:~35kDa;~10 wt% in THF
    In Stock Item #: P773903
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    Technical Identifiers
    IUPAC Name
    butyl 2,2-dimethylbutanoate
    SMILES
    CCCCOC(=O)C(C)(C)CC
    InChIKey
    POIJYXVHIPYSMF-UHFFFAOYSA-N
    InChI
    1S/C10H20O2/c1-5-7-8-12-9(11)10(3,4)6-2/h5-8H2,1-4H3
  11. Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH
    CAS: 1599440-20-6 Formula: C18H25N5O7 Molecular Weight: 423.42
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    Out of Stock Item #: G777630
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    Synonyms
    (S)-16-Amino-10-benzyl-6,9,12,15-tetraoxo-3-oxa-5,8,11,14-tetraazahexadecanoic acid | Glycinamide, glycylglycyl-L-phe...
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