Cross-Coupling Catalysts

Source cross-coupling catalysts for C–C and C–heteroatom bond formation. Use this page to compare catalyst options for Suzuki, Buchwald–Hartwig, Sonogashira, and related transformations.

Browse by type, application, or key specifications such as purity, grade, packaging, and handling requirements.

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  1. Cyclohexyldiphenylphosphine
    CAS: 6372-42-5 EC Number: 228-904-2 Formula: C18H21P Molecular Weight: 268.33
    In Stock Item #: C115369
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    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    cyclohexyl(diphenyl)phosphane
    SMILES
    C1CCC(CC1)P(C2=CC=CC=C2)C3=CC=CC=C3
    InChIKey
    ZXKWUYWWVSKKQZ-UHFFFAOYSA-N
    InChI
    1S/C18H21P/c1-4-10-16(11-5-1)19(17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-2,4-7,10-13,18H,3,8-9,14-15H2
    Synonyms
    Diphenylcyclohexylphosphine | FT-0636122 | BCP05539 | Cyclohexyldiphenylphosphine | Cyclohexyl diphenyl phosphine | D...
  2. Ccesium acetate
    CAS: 3396-11-0 EC Number: 222-248-0 Formula: C2H3CsO2 Molecular Weight: 191.95
    Solid ≥95%
    In Stock Item #: C305845
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    Technical Identifiers
    IUPAC Name
    cesium;acetate
    SMILES
    CC(=O)[O-].[Cs+]
    InChIKey
    ZOAIGCHJWKDIPJ-UHFFFAOYSA-M
    InChI
    1S/C2H4O2.Cs/c1-2(3)4;/h1H3,(H,3,4);/q;+1/p-1
    Synonyms
    Acetic Acid Cesium Salt
  3. Di-tert-butylmethylphosphonium Tetraphenylborate
    CAS: 853073-44-6 Formula: C33H42BP Molecular Weight: 480.48
    Out of Stock Item #: D155650
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    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    ditert-butyl(methyl)phosphanium;tetraphenylboranuide
    SMILES
    [B-](C1=CC=CC=C1)(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.CC(C)(C)[PH+](C)C(C)(C)C
    InChIKey
    GPICDLFVQCUBQN-UHFFFAOYSA-O
    InChI
    1S/C24H20B.C9H21P/c1-5-13-21(14-6-1)25(22-15-7-2-8-16-22,23-17-9-3-10-18-23)24-19-11-4-12-20-24;1-8(2,3)10(7)9(4,5)6/h1-20H;1-7H3/q-1;/p+1
    Synonyms
    GPICDLFVQCUBQN-UHFFFAOYSA-O | MFCD08276365 | AKOS025295829 | D3330 | Di-tert-butylmethylphosphonium Tetraphenylborate...
  4. 1,2-Bis(diphenylphosphino)benzene
    CAS: 13991-08-7 Formula: C6H4[P(C6H5)2]2 Molecular Weight: 446.46
    In Stock Item #: B129163
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    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    (2-diphenylphosphanylphenyl)-diphenylphosphane
    SMILES
    C1=CC=C(C=C1)P(C2=CC=CC=C2)C3=CC=CC=C3P(C4=CC=CC=C4)C5=CC=CC=C5
    InChIKey
    NFRYVRNCDXULEX-UHFFFAOYSA-N
    InChI
    1S/C30H24P2/c1-5-15-25(16-6-1)31(26-17-7-2-8-18-26)29-23-13-14-24-30(29)32(27-19-9-3-10-20-27)28-21-11-4-12-22-28/h1-24H
    Synonyms
    SY038943 | A807594 | EN300-7396611 | FT-0636988 | o-Bis(diphenylphosphino)benzene | SC11532 | (2-dimethylphosphanylph...
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Frequently Asked Questions

How do I choose the right Cross-Coupling Catalysts for my reaction?
Match catalyst structure to your substrate scope, desired selectivity, and reaction conditions. Cross-Coupling Catalysts differ in metal center, ligand framework, and electronic properties. Run small-scale screening with 2-3 candidates before committing to scale-up.
What specifications matter most when comparing Cross-Coupling Catalysts?
Focus on purity (typically ≥95%), particle size or solubility for heterogeneous systems, moisture and air sensitivity, catalyst loading recommendations, and turnover number from published data. Check storage conditions carefully.
How should Cross-Coupling Catalysts be handled and stored?
Most cross-coupling catalysts require inert atmosphere storage (argon or nitrogen). Some are air- and moisture-sensitive — use a glovebox or Schlenk line for measurement. Refrigerated storage at 2-8°C extends shelf life for many products.
Are pre-formed metal complexes available?
Yes. Many cross-coupling catalysts are stocked as pre-formed, ready-to-use complexes that eliminate the need for in-situ ligation. This improves reproducibility and reduces handling of sensitive precursors.

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