2-Ethyl-2-oxazoline - ≥98%(GC) , CAS No.10431-98-8

CAS: 10431-98-8 Cat. No.: E137961 Molecular Weight: 99.13 EC Number: 233-912-4

GRADE & PURITY ≥98%(GC)

Synonyms

2-Ethyloxazoline | starbld0019600 | AKOS015912733 | E78873 | Oxazole, 2-ethyl-4,5-dihydro- | Q26218964 | 2-Ethyl-4,5-dihydro-1,3-oxazole # | EINECS 233-912-4 | B8CD92T4P5 | 2-Oxazoline, 2-ethyl- | UNII-B8CD92T4P5 | Z-1053 | FT-0699359 | InChI=1/C5H9NO/c1-

Storage

Argon charged,Room temperature

Shipped In

Normal

Overview

2-Ethyl-2-oxazoline undergoes cationic ring opening graft polymerization using tosylated cellulose nanowhisker as macroinitiator.
2-Ethyl-2-oxazoline (EtOx) was used in synthesis of block copolymers of EtOx and styrene by cationic ring-opening polymerization and atom transfer radical polymerization.

Specifications

Synonyms

2-Ethyloxazoline | starbld0019600 | AKOS015912733 | E78873 | Oxazole, 2-ethyl-4, 5-dihydro- | Q26218964 | 2-Ethyl-4, 5-dihydro-1, 3-oxazole # | EINECS 233-912-4 | B8CD92T4P5 | 2-Oxazoline, 2-ethyl- | UNII-B8CD92T4P5 | Z-1053 | FT-0699359 | InChI=1/C5H9NO/c1-

Specifications & Purity

≥98%(GC)

Storage

Argon charged, Room temperature

Shipped In

Normal

Purity

≥98%(GC)

Names and Identifiers

• Pubchem Sid: 508808005
• Canonical Smiles: CCC1=NCCO1
• IUPAC Name: 2-ethyl-4,5-dihydro-1,3-oxazole
• InChIKey: NYEZZYQZRQDLEH-UHFFFAOYSA-N
• INCHI: 1S/C5H9NO/c1-2-5-6-3-4-7-5/h2-4H2,1H3
• Isomeric SMILES: CCC1=NCCO1
• WGK Germany: 1
• UN Number: 1993
• Packing Group: III
• Molecular Weight: 99.13
• Reaxy-Rn: 105464
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=105464&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Azolines
      • Subclass Oxazolines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Azolines
• Subclass: Oxazolines
• Intermediate Tree Nodes: Not available
• Direct Parent: Oxazolines
• Alternative Parents: Imidoesters Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Hydrocarbon derivatives
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Oxazoline - Imido ester - Oxacycle - Azacycle - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aliphatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as oxazolines. These are organic compounds containing 1,3-oxazoline, a five-membered ring with a nitrogen and an oxygen atoms at the 1- and 3-position, respectively. Additionally, it contains two double bonds.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Fully miscible in water.
• Sensitivity: air sensitive
• Refractive Index: n20/D 1.437 (lit.)
• Flash Point(°F): 84.2 °F
• Flash Point(°C): 29 °C
• Boil Point(°C): 128.4 °C (lit.)
• Melt Point(°C): −62 °C (lit.)
• Molecular Weight: 99.130 g/mol
• XLogP3: 0.300
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 99.0684 Da
• Monoisotopic Mass: 99.0684 Da
• Topological Polar Surface Area: 21.600 Ų
• Heavy Atom Count: 7
• Formal Charge: 0
• Complexity: 88.100
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Songlin Xing, Qiqi Wang, Yang He, Li Chen.  (2023)  Topology Effects of Poly(2-ethyl-2-oxazoline) Brushes with Various Architectures for Antifouling Behavior under Shear Flow.  BIOMACROMOLECULES,      [PMID:37310151] [10.1021/acs.biomac.3c00298]

2. Qi Chen, Miaoshen Kou, Yang He, Yiping Zhao, Li Chen.  (2022)  Constructing hierarchical surface structure of hemodialysis membranes to intervene in oxidative stress through Michael addition reaction between tannic acid and PEtOx brushes.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2022.120700]

3. Bing Wang, Ping Chen, Ji Zhang, Xiao-Chuan Chen, Yan-Hong Liu, Zheng Huang, Qing-Ying Yu, Ju-Hui Zhang, Wei Zhang, Xi Wei, Xiao-Qi Yu.  (2017)  Self-assembled core–shell-corona multifunctional non-viral vector with AIE property for efficient hepatocyte-targeting gene delivery.  Polymer Chemistry,  8  (48): (7486-7498).  [PMID:] [10.1039/C7PY01520H]

4. Ying-Zi Wu, Yu-Zhuang Gao, Cong-Lei Zhao, Meng-Ying Wu, Yi-Xian Wu.  (2024)  Amphiphilic Diblock Copolymers of Polyisobutylene-b-Poly(2-Ethyl-2-Oxazoline) via Cationic Polymerization.  POLYMER,      [PMID:] [10.1016/j.polymer.2024.127637]

5. Sihan Shen, Ran Xie, Yiqun Wang, Lingyu Jia, Zhangran Zhu, Hai Ma, Lifang Wang, Feng Sui, Yu Zhao, Qinghe Zhao, Yanjun Chen.  (2024)  Ferroptosis mediated inhibition of breast cancer cells by β–elemene incorporated GSH/pH dual responsive nanomicelles.  EUROPEAN POLYMER JOURNAL,      [PMID:] [10.1016/j.eurpolymj.2024.113677]

6. Chengcheng Zhao, Jian Qin, Dingyu Zhang, Xue Li, Ning Yang, Tingyu Gao, Junliang Song, Yule Song, Shouzhen Huang, Huan Xu.  (2025)  NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate enhances the antitumor effect of quercetin liposomes in triple-negative breast cancer.  PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY,      [PMID:39764693] [10.1080/10837450.2025.2450434]

7. Dan-Li Hao, Ran Xie, Ge-Jing De, Hong Yi, Chen Zang, Mi-Yi Yang, Li Liu, Hai Ma, Wei-Yan Cai, Qing-He Zhao, Feng Sui, Yan-Jun Chen.  (2020)  pH-Responsive Artesunate Polymer Prodrugs with Enhanced Ablation Effect on Rodent Xenograft Colon Cancer.  International Journal of Nanomedicine,      [PMID:32214810] [10.2147/IJN.S242032]