AD57 - 10mM in DMSO , CAS No.1093380-42-7

CAS: 1093380-42-7 Cat. No.: A656632 Formula: C₂₂H₂₀F₃N₇O Molecular Weight: 455.44

GRADE & PURITY 10mM in DMSO

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

AD57 is an orally active multikinase inhibitor, inhibits RET , BRAF , S6K and Src , with greatly reduces mTOR activity

In Vitro

AD57 (0.2 nM) significantly inhibits the ptc > dRet MEN2B lethality in the larva of Drosophila. AD57 (0.1 nM) enhances survival of ptc > dRet MEN2B by reducing erk gene dosage in Drosophila. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AD57 inhibits the viability of MEN2B (MZ-CRC-1) and MEN2A (TT) patient-derived cell lines in RET MEN2 models . AD57 (20 mg/kg) significantly inhibits TT-based tumour growth without obvious cytotoxicity in conventional mouse xenograft model . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Braf

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

AD57 is an orally active multikinase inhibitor, inhibits RET , BRAF , S6K and Src , with greatly reduces mTOR activity.

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

Molecular Weight

455.44