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· · COA & SDS available for every product · Same-day shipping on in-stock items AMG 579 - ≥99% , CAS No.1227067-61-9
Synonyms
4-(3-(1-Acetylpiperidine-4-yl)pyrazine-2-yloxy)phenyl(1H-benzoimidazole-2-yl)methanone | 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone | ZNPDAYJZIRPRFQ-UHFFFAOYSA-N | 1-(4-(3-(4-(1H-Benzo(d)imidazole-2-carbonyl)p
Shipped In
Ice chest + Ice pads
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Why this grade ≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC 50 of 0.1 nM.
Form:Solid
IC50& Target:IC50: 0.1 nM (Phosphodiesterase 10A)
Specifications Synonyms
4-(3-(1-Acetylpiperidine-4-yl)pyrazine-2-yloxy)phenyl(1H-benzoimidazole-2-yl)methanone | 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone | ZNPDAYJZIRPRFQ-UHFFFAOYSA-N | 1-(4-(3-(4-(1H-Benzo(d)imidazole-2-carbonyl)p
Specifications & Purity
≥99%
Biochemical and Physiological Mechanisms
AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC 50 of 0.1 nM.
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers Canonical Smiles CC(=O)N1CCC(CC1)C2=NC=CN=C2OC3=CC=C(C=C3)C(=O)C4=NC5=CC=CC=C5N4 IUPAC Name 1-[4-[3-[4-(1H-benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperidin-1-yl]ethanone InChIKey ZNPDAYJZIRPRFQ-UHFFFAOYSA-N INCHI 1S/C25H23N5O3/c1-16(31)30-14-10-17(11-15-30)22-25(27-13-12-26-22)33-19-8-6-18(7-9-19)23(32)24-28-20-4-2-3-5-21(20)29-24/h2-9,12-13,17H,10-11,14-15H2,1H3,(H,28,29) Isomeric SMILES CC(=O)N1CCC(CC1)C2=NC=CN=C2OC3=CC=C(C=C3)C(=O)C4=NC5=CC=CC=C5N4 Alternate CAS 1227067-61-9 PubChem CID 59351313 MeSH Entry Terms 1-(4-(3-(4-(1H-benzo(d)imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone;AMG 579 Molecular Weight 441.48
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organic oxygen compounds Class Organooxygen compounds Subclass Carbonyl compounds Intermediate Tree Nodes Ketones - Aryl ketones - Phenylketones Direct Parent Aryl-phenylketones Alternative Parents Diarylethers N-acylpiperidines Benzimidazoles Phenoxy compounds Phenol ethers Benzoyl derivatives Pyrazines Tertiary carboxylic acid amides Imidazoles Heteroaromatic compounds Acetamides Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Molecular Framework Aromatic heteropolycyclic compounds Substituents Aryl-phenylketone - Diaryl ether - N-acyl-piperidine - Benzimidazole - Phenoxy compound - Phenol ether - Benzoyl - Monocyclic benzene moiety - Piperidine - Pyrazine - Benzenoid - Imidazole - Azole - Tertiary carboxylic acid amide - Heteroaromatic compound - Acetamide - Carboxamide group - Azacycle - Organoheterocyclic compound - Carboxylic acid derivative - Ether - Organic nitrogen compound - Organic oxide - Organonitrogen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as aryl-phenylketones. These are aromatic compounds containing a ketone substituted by one aryl group, and a phenyl group. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility DMSO : 41.67 mg/mL (94.39 mM; Need ultrasonic) Molecular Weight 441.500 g/mol XLogP3 3.000 Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 6 Rotatable Bond Count 5 Exact Mass 441.18 Da Monoisotopic Mass 441.18 Da Topological Polar Surface Area 101.000 Ų Heavy Atom Count 33 Formal Charge 0 Complexity 690.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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