Amthamine dihydrobromide - ≥98% , CAS No.142457-00-9

CAS: 142457-00-9 Cat. No.: A274896 Molecular Weight: 319.06 PubChem CID: 16218912

GRADE & PURITY ≥98%

Synonyms

J-519588 | 5-(2-Aminoethyl)-4-methyl-1,3-thiazol-2-amine--hydrogen bromide (1/2) | FT-0756683 | E98656 | AKOS015908803 | 2-Amino-4-methyl-5-thiazoleethanamine, dihydrobromide | SR-01000597954 | SR-01000597954-1 | Amthamine dihydrobromide, >=98% (HPLC), so

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Overview

Amthamine is a histamine receptor (H1R-H4R) agonist. Amthamine can produce liver congestion and necrosis of liver cells. Amthamine can be used to study the induction effect of H1R-H4 agonist on hepatotoxicity.

Specifications

Synonyms

J-519588 | 5-(2-Aminoethyl)-4-methyl-1, 3-thiazol-2-amine--hydrogen bromide (1/2) | FT-0756683 | E98656 | AKOS015908803 | 2-Amino-4-methyl-5-thiazoleethanamine, dihydrobromide | SR-01000597954 | SR-01000597954-1 | Amthamine dihydrobromide, >=98% (HPLC), so

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Selective H 2 agonist (pK i = 5.2). Weak antagonist of H 3 and displays no activity at H 1 . Increases gastric acid secretion. Additionally increases blood pressure.

Storage

Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

AGONIST

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CC1=C(SC(=N1)N)CCN.Br.Br
• IUPAC Name: 5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine;dihydrobromide
• InChIKey: XFXNNOPUDSFVJE-UHFFFAOYSA-N
• INCHI: 1S/C6H11N3S.2BrH/c1-4-5(2-3-7)10-6(8)9-4;;/h2-3,7H2,1H3,(H2,8,9);2*1H
• Isomeric SMILES: CC1=C(SC(=N1)N)CCN.Br.Br
• PubChem CID: 16218912
• Molecular Weight: 319.06

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Azoles
      • Subclass Thiazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Azoles
• Subclass: Thiazoles
• Intermediate Tree Nodes: Not available
• Direct Parent: 2,4,5-trisubstituted thiazoles
• Alternative Parents: 2-arylethylamines Aralkylamines 2-amino-1,3-thiazoles Heteroaromatic compounds Azacyclic compounds Monoalkylamines Hydrocarbon derivatives Hydrobromides
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: 2-arylethylamine - 2,4,5-trisubstituted 1,3-thiazole - Aralkylamine - 1,3-thiazol-2-amine - Heteroaromatic compound - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Hydrobromide - Primary amine - Organonitrogen compound - Primary aliphatic amine - Amine - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as 2,4,5-trisubstituted thiazoles. These are compounds containing a thiazole ring substituted at positions 2, 4 and 5 only.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Soluble in water to 100 mM
• Sensitivity: Moisture sensitive
• Molecular Weight: 319.060 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 318.918 Da
• Monoisotopic Mass: 316.92 Da
• Topological Polar Surface Area: 93.200 Ų
• Heavy Atom Count: 12
• Formal Charge: 0
• Complexity: 109.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

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