Asaraldehyde - 10mM in DMSO , CAS No.4460-86-0

CAS: 4460-86-0 Cat. No.: A408453 Formula: C₁₀H₁₂O₄ Molecular Weight: 196.2 Beilstein Registry Number: 1951403 EC Number: 224-713-3 PubChem CID: 20525

GRADE & PURITY 10mM in DMSO

Synonyms

Asaronaldehyde | 2,​4,​5-​trimethoxy-benzaldehyde

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Asaraldehyde (Asaronaldehyde) is a naturalCOX-2inhibitor, exhibiting 17-fold selectivity over COX-1.
In vitro

Asaraldehyde is found to be the most abundant constituent, but is totally absent in its cultured broth and its natural host, C. kanehirae wood. On feeding with the acid-digested sawdust of C. kanehirae wood or vanillin to the broth for culture, Asaraldehyde is produced in both cultured broths. Asaraldehyde shows 3.32% of prostaglandin H endoperoxide synthase-1 (COX-1) inhibitory activity and 52.69% prostaglandin H endoperoxide synthase-2 (COX-2) inhibitory activity, respectively at 100 mg/mL. Asaraldehyde shows selectivity towards COX-2 enzyme inhibition at 100 µg/mL. The COX-2/COX-1 ratio for Asaraldehyde is 17.68 at 100 µg/mL compared to solvent control. Asaraldehyde down-regulates C/EBPβ, C/EBPδ, and C/EBPα. Asaraldehyde suppresses expression of PPARγ1 and PPARγ2. Asaraldehyde also significantly suppresses the expression of acetyl-CoA carboxylase (ACC).

In vivo

Cell Data

cell lines：VSMC cells

Concentrations：100 μg/mL

Incubation Time：24 hours

Powder Purity:≥100%

Specifications

Synonyms

Asaronaldehyde | 2,​4,​5-​trimethoxy-benzaldehyde

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Asaraldehyde (Asaronaldehyde) is a natural COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: COC1=CC(=C(C=C1C=O)OC)OC
• WGK Germany: 3
• RTECS: CU8460000
• PubChem CID: 20525
• Molecular Weight: 196.2
• Beilstein: 1951403
• Reaxy-Rn: 1951403

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 2 mg/mL (5.99 mM); Water: Insoluble; Ethanol: Insoluble
• Boil Point(°C): 140 °C/4 mmHg
• Melt Point(°C): 109-112°C

Frequently Asked Questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 4460-86-0, the molecular formula is C10H12O4, and the molecular weight is 196.2 g/mol.