Beraprost sodium - ≥99% , CAS No.496807-11-5

CAS: 496807-11-5 Cat. No.: B651330 Formula: C₂₄H₂₉NaO₅ Molecular Weight: 420.47 PubChem CID: 101623382

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

Beraprost sodium, a prostacyclin analog, is a stable and orally active proagent of PGI2 . Beraprost sodium is a potent vasodilator , has the potential for pulmonary arterial hypertension treatment through expanding renal vessels, improving microcirculation

In Vitro

Beraprost sodium (0.1, 1.0, and 10.0 μM; 24 hours) treatment leads to a significant increase in the number of tube formation, BPS plays an important role on angiogenic activity. Beraprost sodium (0.1, 1.0, and 10.0 μM; 24 hours) treatment let VE-cadherin at regions of cell–cell contact becomes more abundant and the morphology of endothelial cells tends to be normal compared with those cultured under hypoxia conditions. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Beraprost sodium (oral adminstration; 0.6 mg/kg; once daily; 3 or 7 days) can mitigate the development of renal interstitial fibrosis, decrease renal oxidative stress through its potential vasodilation effect, and further prevent renal interstitial fibrosis . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 6-8-week-old C57Bl/6J Male Mice Dosage: 0.6 mg/kg Administration: Oral adminstration; 0.6 mg/kg; once daily; 3 or 7 days Result: Mitigated the development of renal interstitial fibrosis.

Form:Solid

IC50& Target:IP

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Beraprost sodium, a prostacyclin analog, is a stable and orally active proagent of PGI2 . Beraprost sodium is a potent vasodilator , has the potential for pulmonary arterial hypertension treatment through expanding renal vessels, improving microcirculatio

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

Canonical Smiles

CC#CCC(C)C(C=CC1C(CC2C1C3=CC=CC(=C3O2)CCCC(=O)[O-])O)O.[Na+]

IUPAC Name

sodium;4-[(1S,2S,3aR,8bR)-2-hydroxy-1-[(E,3R)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate

InChIKey

YTCZZXIRLARSET-WGMXHSAISA-M

INCHI

1S/C24H30O5.Na/c1-3-4-7-15(2)19(25)13-12-17-20(26)14-21-23(17)18-10-5-8-16(24(18)29-21)9-6-11-22(27)28;/h5,8,10,12-13,15,17,19-21,23,25-26H,6-7,9,11,14H2,1-2H3,(H,27,28);/q;+1/p-1/b13-12+;/t15?,17-,19+,20+,21-,23-;/m1./s1

Isomeric SMILES

CC#CCC(C)[C@H](/C=C/[C@@H]1[C@H](C[C@@H]2[C@H]1C3=CC=CC(=C3O2)CCCC(=O)[O-])O)O.[Na+]

PubChem CID

101623382

MeSH Entry Terms

4-(1,2,3a,8b-tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyloct-6-yne-1-enyl)-5-cyclopenta(b)benzofuranyl)butyrate;beraprost;beraprost sodium;TRK 100;TRK-100

Molecular Weight

420.47

Chemical and Physical Properties

• Solubility: DMSO : 125 mg/mL (297.29 mM; Need ultrasonic)