BV-6 TFA salt - Moligand™, ≥98% , CAS No.1001600-56-1(freebase)
In stock
SKU
B413788
XIAP Selective Inhibitors | Antagonists
Information
BV-6 is a SMAC mimetic, dualcIAPandXIAPinhibitor.
Targets
cIAP ; XIAP
In vitro
BV6 inhibits the cell viability of HCC193 NSCLC cells with IC50 of 7.2 μM, induces apoptosis in both HCC193 and H460 cell lines, and also significantly enhances the radiosensitivity of these cell lines through activation of cleaved caspase-8 and cleaved caspase-9, respectively. In immature dendritic cells, BV-6 treatment results in moderate activation of the classical NF-kB pathway. Furthermore, BV-6 increases CIK cell-mediated lysis of hematological (H9, THP-1, and Tanoue) and solid malignancies (RH1, RH30, and TE671). BV-6 also enhances apoptosis of peripheral blood mononuclear cells and most notably has an inhibitory effect on immune cells limiting their cytotoxic potential.
Cell Research(from reference)
Cell lines：HCC193 and H460 cells
Concentrations：~30 μM
Incubation Time：~48 hours
More Information
| CAS | 1001600-56-1(freebase) |
|---|---|
| Synonyms | N,N'-(hexane-1,6-diyl)bis(1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-L-prolyl-beta-phenyl-L-phenylalaninamide):trifluoroacetic acid(1:x) |
| Specifications & Purity | Moligand™, ≥98% |
| Storage | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Information BV-6 is a SMAC mimetic, dualcIAPandXIAPinhibitor. Targets cIAP ; XIAP In vitro BV6 inhibits the cell viability of HCC193 NSCLC cells with IC50 of 7.2 μM, induces apoptosis in both HCC193 and H460 cell lines, and also significantly enhances the radiosensitivity of these cell lines through activation of cleaved caspase-8 and cleaved caspase-9, respectively. In immature dendritic cells, BV-6 treatment results in moderate activation of the classical NF-kB pathway. Furthermore, BV-6 increases CIK cell-mediated lysis of hematological (H9, THP-1, and Tanoue) and solid malignancies (RH1, RH30, and TE671). BV-6 also enhances apoptosis of peripheral blood mononuclear cells and most notably has an inhibitory effect on immune cells limiting their cytotoxic potential. Cell Research(from reference) Cell lines：HCC193 and H460 cells Concentrations：~30 μM Incubation Time：~48 hours |
| Pubchem Sid | 488200364 |
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488200364 |
| Solubility | Solubility (25°C) In vitro DMSO: 100 mg/mL (82.94 mM); Water: 100 mg/mL (82.94 mM); Ethanol: 100 mg/mL warmed with 50ºC Water: bath (82.94 mM); |
| Target | XIAP |
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