10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 4 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Information
Carvedilol (BM-14190, SKF 105517) is a non-selectivebeta blocker/alpha-1blocker, used to treat congestive heart failure (CHF) and high blood pressure. In vitro
Carvedilol rapidly inhibits Fe(++)-initiated lipid peroxidation, measured as thiobarbituric acid reactive substance (TBARS), in rat brain homogenate with an IC50 of 8.1 mM. Carvedilol protects against Fe(++)-induced alpha-tocopherol depletion in rat brain homogenate with an IC50 of 17.6 mM. Carvedilol dose-dependently decreases the intensity of the DMPO-OH signal with an IC50 of 25 mM. Carvedilol has inverse efficacy for stimulating G(s)-dependent adenylyl cyclase but stimulates phosphorylation of the receptor\'s cytoplasmic tail on previously documented G protein-coupled receptor kinase sites in beta2 adrenergic receptor (beta2AR)-expressing HEK-293 cells. Carvedilol (0.1-10 mM) produces a concentration-dependent inhibition of the mitogenesis stimulated by platelet-derived growth factor, epidermal growth factor, thrombin, and serum in human cultured pulmonary artery vascular smooth muscle cells, with IC50 values ranging from 0.3 mM to 2.0 mM. Carvedilol also produces a concentration-dependent inhibition of vascular smooth muscle cell migration induced by platelet-derived growth factor, with an IC50 value of 3 mM. Carvedilol decreases the extent of cellular vacuolization in cardiac myocytes and prevents the inhibitory effect of doxorubicin on mitochondrial respiration in both heart and liver. Carvedilol also prevents the decrease in mitochondrial Ca(2+) loading capacity and the inhibition of the respiratory complexes of heart mitochondria caused by doxorubicin.
Carvedilol (BM-14190, SKF 105517) is a non-selective beta blocker/alpha-1 blocker, used to treat congestive heart failure (CHF) and high blood pressure.
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
1.Hongqiu Zhou, Li Yang, Changsuo Wang, Zhiqiang Li, Zhen Ouyang, Mangting Shan, Jun Gu, Yuan Wei. (2019) CYP2D1 Gene Knockout Reduces the Metabolism and Efficacy of Venlafaxine in Rats. DRUG METABOLISM AND DISPOSITION, 47 (12):(1425-1432). [PMID:31658948][10.1124/dmd.119.088526]
2.Xue Ren, Man He, Beibei Chen, Bin Hu. (2019) Magnetic porous organic polymers for extraction of cardiovascular drugs in human urine samples followed by HPLC-UV. Analytical Methods, 12 (2):(141-148). [PMID:][10.1039/C9AY02041A]
3.Wenying Fan, Man He, Linna You, Xuewei Zhu, Beibei Chen, Bin Hu. (2016) Water-compatible graphene oxide/molecularly imprinted polymer coated stir bar sorptive extraction of propranolol from urine samples followed by high performance liquid chromatography-ultraviolet detection. JOURNAL OF CHROMATOGRAPHY A, [PMID:26993782][10.1016/j.chroma.2016.03.017]
4.Xiaofeng Wu, Wenqi Liu, Shuyi He, Linyu Long, Hongxu Peng, Li Yang, Yunbing Wang. (2025) An injectable hydrogel loaded with deferoxamine and carvedilol for the treatment of acute myocardial infarction. CHEMICAL ENGINEERING JOURNAL, [PMID:][10.1016/j.cej.2025.166294]
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