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PI3K/Akt/mTOR

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  1. LY2090314 - Moligand™, ≥98% CAS No(603288-22-8) by Aladdin Scientific
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    LY2090314, Inhibitor of glycogen synthase kinase 3 beta
    CAS: 603288-22-8 EC Number: 110-218-9 Formula: C28H25FN6O3 Molecular Weight: 512.53
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: L126079
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    IUPAC Name
    3-[6-fluoro-10-(piperidine-1-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]-4-imidazo[1,2-a]pyridin-3-ylpyrrole-2,5-dione
    SMILES
    C1CCN(CC1)C(=O)N2CCN3C=C(C4=CC(=CC(=C43)C2)F)C5=C(C(=O)NC5=O)C6=CN=C7N6C=CC=C7
    InChIKey
    HRJWTAWVFDCTGO-UHFFFAOYSA-N
    InChI
    1S/C28H25FN6O3/c29-18-12-17-15-34(28(38)32-7-3-1-4-8-32)11-10-33-16-20(19(13-18)25(17)33)23-24(27(37)31-26(23)36)21-14-30-22-6-2-5-9-35(21)22/h2,5-6,9show more
    Synonyms
    ?-(Trichloromethyl)-4-pyridineethanol | AS-56097 | Kinome_3681 | LY2090314 | LY-2090314 | LY 2090314 | NSC801005 | NS...
  2. INCB-047775
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    INCB-047775
    CAS: 1430056-54-4 PubChem CID: 89499684 Formula: C22H20FN5O Molecular Weight: 389.434
    ≥97%
    ◐ .Made to order · 8–12 wks Item #: I174181
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    Technical Identifiers
    IUPAC Name
    5-[2-[(2S)-1-amino-3-(3-fluorophenyl)propan-2-yl]-1-oxo-3H-isoindol-5-yl]-1-methylpyrazole-4-carbonitrile
    SMILES
    CN1C(=C(C=N1)C#N)C2=CC3=C(C=C2)C(=O)N(C3)C(CC4=CC(=CC=C4)F)CN
    InChIKey
    QXRHOURHCGFDIM-IBGZPJMESA-N
    InChI
    1S/C22H20FN5O/c1-27-21(17(10-24)12-26-27)15-5-6-20-16(9-15)13-28(22(20)29)19(11-25)8-14-3-2-4-18(23)7-14/h2-7,9,12,19H,8,11,13,25H2,1H3/t19-/m0/s1
  3. TWS 119 - ≥98%(HPLC) CAS No(1507095-58-0) by Aladdin Scientific
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    TWS 119
    CAS: 1507095-58-0 PubChem CID: 90488884 Formula: C22H16F6N4O6 Molecular Weight: 546.38
    ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: T288232
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    Technical Identifiers
    IUPAC Name
    3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol;2,2,2-trifluoroacetic acid
    SMILES
    C1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O
    InChIKey
    XJEFPMFFWJTJSL-UHFFFAOYSA-N
    InChI
    1S/C18H14N4O2.2C2HF3O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14;2*3-2(4,5)1(6)7/h1-10,23H,19H2,(H,20,21,22);2*(H,6,show more
    Synonyms
    3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxyphenol ditrifluoroacetate
  4. TC KHNS 11 - ≥95% CAS No(1431540-99-6) by Aladdin Scientific
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    TC KHNS 11
    CAS: 1431540-99-6 PubChem CID: 86732669 Formula: C28H24N6O3 Molecular Weight: 492.53
    ≥95%
    ◐ .Made to order · 8–12 wks Item #: T287117
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    Technical Identifiers
    IUPAC Name
    5-[4-[3-(4-acetylpiperazine-1-carbonyl)phenyl]quinazolin-6-yl]-2-methoxypyridine-3-carbonitrile
    SMILES
    CC(=O)N1CCN(CC1)C(=O)C2=CC=CC(=C2)C3=NC=NC4=C3C=C(C=C4)C5=CC(=C(N=C5)OC)C#N
    InChIKey
    QYTXJLQBSYAMGR-UHFFFAOYSA-N
    InChI
    1S/C28H24N6O3/c1-18(35)33-8-10-34(11-9-33)28(36)21-5-3-4-20(12-21)26-24-14-19(6-7-25(24)31-17-32-26)23-13-22(15-29)27(37-2)30-16-23/h3-7,12-14,16-17H,show more
    Synonyms
    5-[4-[3-[(4-Acetyl-1-piperazinyl)carbonyl]phenyl]-6-quinazolinyl]-2-methoxy-3-pyridinecarbonitrile
  5. Z-Guggulsterone - ≥98% CAS No(39025-23-5) by Aladdin Scientific
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    Z-Guggulsterone
    CAS: 39025-23-5 EC Number: 609-604-4 Formula: C21H28O2 Molecular Weight: 312.45
    ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: Z136302
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    IUPAC Name
    (8R,9S,10R,13S,14S,17Z)-17-ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione
    SMILES
    CC=C1C(=O)CC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
    InChIKey
    WDXRGPWQVHZTQJ-OSJVMJFVSA-N
    InChI
    1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+/t15-,17+,18+,20+,21-/m1/s1
    Synonyms
    AVQFHKYAVVQYQO-UHFFFAOYSA- | 6CST3U34GN | GUGGULSTERONE Z [USP-RS] | NCGC00260067-01 | Z/E-Guggulsterone | AC-28813 |...
  6. PKI-179, PI3-kinase p110-alpha subunit inhibitor
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    PKI-179, PI3-kinase p110-alpha subunit inhibitor
    CAS: 1197160-28-3 PubChem CID: 46947264 Formula: C25H28N8O3 Molecular Weight: 488.54
    ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: P345208
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    Technical Identifiers
    IUPAC Name
    1-[4-[4-morpholin-4-yl-6-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-1,3,5-triazin-2-yl]phenyl]-3-pyridin-4-ylurea
    SMILES
    C1CC2COCC1N2C3=NC(=NC(=N3)N4CCOCC4)C5=CC=C(C=C5)NC(=O)NC6=CC=NC=C6
    InChIKey
    WXUUCRLKXQMWRY-UHFFFAOYSA-N
    InChI
    1S/C25H28N8O3/c34-25(28-19-7-9-26-10-8-19)27-18-3-1-17(2-4-18)22-29-23(32-11-13-35-14-12-32)31-24(30-22)33-20-5-6-21(33)16-36-15-20/h1-4,7-10,20-21H,5show more
    Synonyms
    PKI-179 | 1-{4-[4-morpholin-4-yl-6-(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]phenyl}-3-pyridin-4-ylurea ...
  7. Cryptochlorogenic acid - analytical standard,Moligand™ CAS No(905-99-7) by Aladdin Scientific
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    Cryptochlorogenic acid
    CAS: 905-99-7 Formula: C16H18O9 Molecular Weight: 354.31
    Solid Analytical standard ? Analytical standard — certified-purity material for quantitative calibration. Use to prepare calibration standards and validate analytical methods. Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ● In Stock — US warehouse, ships to EU* Item #: C117944
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    IUPAC Name
    (3R,5R)-4-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-1,3,5-trihydroxycyclohexane-1-carboxylic acid
    SMILES
    C1C(C(C(CC1(C(=O)O)O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)O
    InChIKey
    GYFFKZTYYAFCTR-AVXJPILUSA-N
    InChI
    1S/C16H18O9/c17-9-3-1-8(5-10(9)18)2-4-13(21)25-14-11(19)6-16(24,15(22)23)7-12(14)20/h1-5,11-12,14,17-20,24H,6-7H2,(H,22,23)/b4-2+/t11-,12-,14?,16?/m1/show more
    Synonyms
    Cinnamic acid, 3,4-dihydroxy-, 4-carboxy-2,4,6-trihydroxycyclohexyl ester | Cyclohexanecarboxylic acid, 4-((3-(3,4-di...
  8. Oridonin - ≥98% CAS No(28957-04-2) by Aladdin Scientific
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    Oridonin
    CAS: 28957-04-2 EC Number: 631-100-8 Formula: C20H28O6 Molecular Weight: 364.43
    ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: O111382
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    Technical Identifiers
    IUPAC Name
    (1S,2S,5S,8R,9S,10S,11R,15S,18R)-9,10,15,18-tetrahydroxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-7-one
    SMILES
    CC1(CCC(C23C1C(C(C45C2CCC(C4O)C(=C)C5=O)(OC3)O)O)O)C
    InChIKey
    SDHTXBWLVGWJFT-XKCURVIJSA-N
    InChI
    1S/C20H28O6/c1-9-10-4-5-11-18-8-26-20(25,19(11,14(9)22)15(10)23)16(24)13(18)17(2,3)7-6-12(18)21/h10-13,15-16,21,23-25H,1,4-8H2,2-3H3/t10-,11-,12-,13+,show more
    Synonyms
    ORIDONIN [INCI] | NSC-250682; Isodonol | Rubescenin | DTXSID201021760 | KAUR-16-EN-15-ONE, 7,20-EPOXY-1,6,7,14-TETRAH...
  9. Dihydromyricetin
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    Dihydromyricetin
    CAS: 27200-12-0 Formula: C15H12O8 Molecular Weight: 320.25
    Analytical standard ? Analytical standard — certified-purity material for quantitative calibration. Use to prepare calibration standards and validate analytical methods. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: D101549
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    IUPAC Name
    (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one
    SMILES
    C1=C(C=C(C(=C1O)O)O)C2C(C(=O)C3=C(C=C(C=C3O2)O)O)O
    InChIKey
    KJXSIXMJHKAJOD-LSDHHAIUSA-N
    InChI
    1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1
    Synonyms
    (2R,3R)-2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one | HY-N0112 | Dihydromyricetin (...
  10. SH-5
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    SH-5
    CAS: 701976-54-7 PubChem CID: 10326220 Formula: C29H59O10P Molecular Weight: 598.75
    ≥98%
    ◐ .Made to order · 8–12 wks Item #: S275226
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    Technical Identifiers
    IUPAC Name
    (2-methoxy-3-octadecoxypropyl) (2,3,4-trihydroxy-6-methoxycyclohexyl) hydrogen phosphate
    SMILES
    CCCCCCCCCCCCCCCCCCOCC(COP(=O)(O)OC1C(CC(C(C1O)O)O)OC)OC
    InChIKey
    NRLLDDPUQZQEDV-UHFFFAOYSA-N
    InChI
    1S/C29H59O10P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-37-22-24(35-2)23-38-40(33,34)39-29-26(36-3)21-25(30)27(31)28(29)32/h24-32H,4-23H2,1-3H3,show more
    Synonyms
    [(2R)-2-Methoxy-3-octadecoxypropyl](2,3,4-trihydroxy-6-methoxycyclohexyl)hydrogenphosphate
  11. Linolenic Acid-¹³C18
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    Linolenic Acid-¹³C18
    CAS: 287111-28-8 Formula: (13C)18H30O2 Molecular Weight: 296.3
    ≥98 atom% 13C18,≥95%
    ● In Stock — US warehouse, ships to EU* Item #: L333872
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    Technical Identifiers
    IUPAC Name
    (9Z,12Z,15Z)-(1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18-13C18)octadeca-9,12,15-trienoic acid
    SMILES
    CCC=CCC=CCC=CCCCCCCCC(=O)O
    InChIKey
    DTOSIQBPPRVQHS-JHNAZIRYSA-N
    InChI
    1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-/i1+1,2+1,3+1,4+1,5+1,6+1,7show more
    Synonyms
    (9Z,12Z,15Z)-9,12,15-Octadecatrienoic Acid-13C18 | HY-N0728S3 | J-017209 | SCHEMBL1331592 | (9Z,12Z,15Z)-(~13~C_18_)O...
  12. UCN-01, Inhibitor of 3-phosphoinositide dependent protein kinase 1;Inhibitor of checkpoint kinase 1;Inhibitor of checkpoint kinase 2;Inhibitor of cyclin dependent kinase 1;Inhibitor of glycogen synthase kinase 3 beta;Inhibitor of LCK proto-oncogene; Src family ty
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    UCN-01, Inhibitor of 3-phosphoinositide dependent protein kinase 1;Inhibitor of checkpoint kinase 1;Inhibitor of checkpoint kinase 2;Inhibitor of cyclin dependent kinase 1;Inhibitor of glycogen synthase kinase 3 beta;Inhibitor of LCK proto-oncogene; Src family ty
    CAS: 112953-11-4 PubChem CID: 72271 Formula: C28H26N4O4 Molecular Weight: 482.53
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: U138038
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    Technical Identifiers
    IUPAC Name
    (2S,3R,4R,6R,18R)-18-hydroxy-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8show more
    SMILES
    CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(NC6=O)O)NC)OC
    InChIKey
    PBCZSGKMGDDXIJ-HQCWYSJUSA-N
    InChI
    1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,show more
    Synonyms
    BDBM17054 | NSC638850 | NSC-638850 | 7-Hydroxystaurosporine [WHO-DD] | KRX0601 | KRX-0601 | Dietilamina | Isocyanic a...
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