AAK1

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  1. SGC AAK1 1
    CAS: 2247894-32-0 PubChem CID: 134812845 Formula: C21H25N5O3S Molecular Weight: 427.52
    ● In Stock — US warehouse, ships to EU* Item #: S288249
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    Technical Identifiers
    IUPAC Name
    N-[6-[3-(diethylsulfamoylamino)phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
    SMILES
    CCN(CC)S(=O)(=O)NC1=CC=CC(=C1)C2=CC3=C(C=C2)C(=NN3)NC(=O)C4CC4
    InChIKey
    UCBIQZUJJSVQHL-UHFFFAOYSA-N
    InChI
    1S/C21H25N5O3S/c1-3-26(4-2)30(28,29)25-17-7-5-6-15(12-17)16-10-11-18-19(13-16)23-24-20(18)22-21(27)14-8-9-14/h5-7,10-14,25H,3-4,8-9H2,1-2H3,(H2,22,23,show more
    Synonyms
    N-(6-(3-((N,N-diethylsulfamoyl)amino)phenyl)-1H-indazol-3-yl)cyclopropanecarboxamide
  2. LP-922761
    CAS: 1454808-95-7 Formula: C21H26N6O3 Molecular Weight: 410.47
    ◐ .Made to order · 8–12 wks Item #: L287650
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    IUPAC Name
    tert-butyl N-[2-[[3-(4-carbamoylphenyl)imidazo[1,2-b]pyridazin-6-yl]amino]ethyl]-N-methylcarbamate
    SMILES
    CC(C)(C)OC(=O)N(C)CCNC1=NN2C(=NC=C2C3=CC=C(C=C3)C(=O)N)C=C1
    InChIKey
    YNQNYIHMAZLJAV-UHFFFAOYSA-N
    InChI
    1S/C21H26N6O3/c1-21(2,3)30-20(29)26(4)12-11-23-17-9-10-18-24-13-16(27(18)25-17)14-5-7-15(8-6-14)19(22)28/h5-10,13H,11-12H2,1-4H3,(H2,22,28)(H,23,25)
    Synonyms
    tert-Butyl (2-((3-(4-carbamoylphenyl)imidazo[1,2-b]pyridazin-6-yl)amino)ethyl)(methyl)carbamate
  3. BMS-986176, Inhibitor of AP2 associated kinase 1
    CAS: 1815613-42-3 EC Number: 879-754-5 PubChem CID: 118419773 Formula: C19H23F4N3O Molecular Weight: 385.40
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: B608154
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    IUPAC Name
    (2S)-1-[2-(difluoromethyl)-6-[2-(difluoromethyl)pyridin-4-yl]pyridin-3-yl]oxy-2,4-dimethylpentan-2-amine
    SMILES
    CC(C)CC(C)(COC1=C(N=C(C=C1)C2=CC(=NC=C2)C(F)F)C(F)F)N
    InChIKey
    RKAHOQATMSONTM-IBGZPJMESA-N
    InChI
    1S/C19H23F4N3O/c1-11(2)9-19(3,24)10-27-15-5-4-13(26-16(15)18(22)23)12-6-7-25-14(8-12)17(20)21/h4-8,11,17-18H,9-10,24H2,1-3H3/t19-/m0/s1
    Synonyms
    US10155760, Example 123 | BMS-986176 | 1815613-42-3 | 9G4RLM5X6Z | UNII-9G4RLM5X6Z | LX9211 | LX-9211 | AAK1-IN-1 | (...
  4. BMS-911172, Inhibitor of AP2 associated kinase 1
    CAS: 1644248-18-9 PubChem CID: 86582964 Formula: C16H19F2N3O3 Molecular Weight: 339.34
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: B608142
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    IUPAC Name
    (2R)-2-amino-N-[3-(difluoromethoxy)-4-(1,3-oxazol-5-yl)phenyl]-4-methylpentanamide
    SMILES
    N[C@@H](C(=O)Nc1cc(c(cc1)c1cnco1)OC(F)F)CC(C)C
    InChIKey
    GCTFTMWXZFLTRR-GFCCVEGCSA-N
    InChI
    1S/C16H19F2N3O3/c1-9(2)5-12(19)15(22)21-10-3-4-11(14-7-20-8-23-14)13(6-10)24-16(17)18/h3-4,6-9,12,16H,5,19H2,1-2H3,(H,21,22)/t12-/m1/s1
    Synonyms
    BMS911172 | compound 59
  5. LP-935509
    CAS: 1454555-29-3 EC Number: 884-546-2 PubChem CID: 86697436 Formula: C20H24N6O3 Molecular Weight: 396.44
    ◐ .Made to order · 8–12 wks Item #: L647310
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    IUPAC Name
    propan-2-yl 4-[3-(2-methoxypyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl]piperazine-1-carboxylate
    SMILES
    CC(C)OC(=O)N1CCN(CC1)C2=NC3=C(C=NN3C=C2)C4=C(N=CC=C4)OC
    InChIKey
    GOOYSJIWTIHOGW-UHFFFAOYSA-N
    InChI
    1S/C20H24N6O3/c1-14(2)29-20(27)25-11-9-24(10-12-25)17-6-8-26-18(23-17)16(13-22-26)15-5-4-7-21-19(15)28-3/h4-8,13-14H,9-12H2,1-3H3
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R&D Use Only Products supplied for research and development use

Frequently Asked Questions

Which compounds are listed for AAK1?
Compounds associated with AAK1 are grouped here under the Neuronal Signaling classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.
How does AAK1 sit within Neuronal Signaling?
AAK1 is one target listing within the Neuronal Signaling classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.
What data should I check before ordering a compound from AAK1?
For compounds listed under AAK1, check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
How do I find related targets or backup compounds for AAK1?
Browse the parent Neuronal Signaling listing to reach targets neighbouring AAK1, and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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