Aldose Reductase

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  1. Isoliquiritigenin
    CAS: 961-29-5 EC Number: 677-489-8 Formula: C15H12O4 Molecular Weight: 256.25
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: I111284
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    IUPAC Name
    (E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
    SMILES
    C1=CC(=CC=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O
    InChIKey
    DXDRHHKMWQZJHT-FPYGCLRLSA-N
    InChI
    1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+
    Synonyms
    SMR000112969 | EU-0100681 | NCGC00261366-01 | SR-01000075499 | (E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-prop...
  2. Alrestatin
    CAS: 51411-04-2 Formula: C14H9NO4 Molecular Weight: 255.23
    ● In Stock — US warehouse, ships to EU* Item #: A288688
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    IUPAC Name
    2-(1,3-dioxobenzo[de]isoquinolin-2-yl)acetic acid
    SMILES
    C1=CC2=C3C(=C1)C(=O)N(C(=O)C3=CC=C2)CC(=O)O
    InChIKey
    GCUCIFQCGJIRNT-UHFFFAOYSA-N
    InChI
    1S/C14H9NO4/c16-11(17)7-15-13(18)9-5-1-3-8-4-2-6-10(12(8)9)14(15)19/h1-6H,7H2,(H,16,17)
    Synonyms
    KBioGR_000484 | BCP28030 | AKOS000143709 | s5803 | 2-{2,4-dioxo-3-azatricyclo[7.3.1.0,5,13]trideca-1(13),5,7,9,11-pen...
  3. Sulindac Sulfone
    CAS: 59864-04-9 PubChem CID: 6158261 Formula: C20H17FO4S Molecular Weight: 372.4
    ◐ .Made to order · 8–12 wks Item #: S347766
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    IUPAC Name
    2-[(3E)-6-fluoro-2-methyl-3-[(4-methylsulfonylphenyl)methylidene]inden-1-yl]acetic acid
    SMILES
    CC1=C(C2=C(C1=CC3=CC=C(C=C3)S(=O)(=O)C)C=CC(=C2)F)CC(=O)O
    InChIKey
    MVGSNCBCUWPVDA-RQZCQDPDSA-N
    InChI
    1S/C20H17FO4S/c1-12-17(9-13-3-6-15(7-4-13)26(2,24)25)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9+
    Synonyms
    Exisulind | Aptosyn | Prevatec
  4. Epalrestat, Aldose reductase inhibitor
    CAS: 82159-09-9 EC Number: 675-018-0 Formula: C15H13NO3S2 Molecular Weight: 319.4
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
    ● In Stock — US warehouse, ships to EU* Item #: E129897
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    IUPAC Name
    2-[(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid
    SMILES
    CC(=CC1=CC=CC=C1)C=C2C(=O)N(C(=S)S2)CC(=O)O
    InChIKey
    CHNUOJQWGUIOLD-NFZZJPOKSA-N
    InChI
    1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8-
    Synonyms
    HMS3887A17 | {5-[(E)-2-Methyl-3-phenyl-prop-2-en-(Z)-ylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-acetic acid | GTPL1137...
  5. Isoliquiritigenin
    CAS: 961-29-5 EC Number: 677-489-8 Formula: C15H12O4 Molecular Weight: 256.25
    Solid Analytical standard ? Analytical standard — certified-purity material for quantitative calibration. Use to prepare calibration standards and validate analytical methods. Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ● In Stock — US warehouse, ships to EU* Item #: I111283
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    IUPAC Name
    (E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
    SMILES
    C1=CC(=CC=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O
    InChIKey
    DXDRHHKMWQZJHT-FPYGCLRLSA-N
    InChI
    1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+
    Synonyms
    SMR000112969 | EU-0100681 | NCGC00261366-01 | SR-01000075499 | (E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-prop...
  6. Tolrestat(AY-27773), Aldose reductase inhibitor
    CAS: 82964-04-3 PubChem CID: 53359 Formula: C16H14F3NO3S Molecular Weight: 357.35
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Made to order · 8–12 wks Item #: T304733
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    IUPAC Name
    2-[[6-methoxy-5-(trifluoromethyl)naphthalene-1-carbothioyl]-methylamino]acetic acid
    SMILES
    CN(CC(=O)O)C(=S)C1=CC=CC2=C1C=CC(=C2C(F)(F)F)OC
    InChIKey
    LUBHDINQXIHVLS-UHFFFAOYSA-N
    InChI
    1S/C16H14F3NO3S/c1-20(8-13(21)22)15(24)11-5-3-4-10-9(11)6-7-12(23-2)14(10)16(17,18)19/h3-7H,8H2,1-2H3,(H,21,22)
    Synonyms
    DTXSID80904890 | Tolrestatin | N-(6-Methoxythio-5-(trifluoromethyl)-1-naphthoyl)sarcosine | N-[[6-Methoxy-5-(trifluor...
  7. 2-Chloro-1-(4-fluorobenzyl)benzimidazole
    CAS: 84946-20-3 Formula: C14H10ClFN2 Molecular Weight: 260.69
    ● In Stock — US warehouse, ships to EU* Item #: C136902
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    Technical Identifiers
    IUPAC Name
    2-chloro-1-[(4-fluorophenyl)methyl]benzimidazole
    SMILES
    C1=CC=C2C(=C1)N=C(N2CC3=CC=C(C=C3)F)Cl
    InChIKey
    PGXALMVNIRPELS-UHFFFAOYSA-N
    InChI
    1S/C14H10ClFN2/c15-14-17-12-3-1-2-4-13(12)18(14)9-10-5-7-11(16)8-6-10/h1-8H,9H2
    Synonyms
    C2850 | SCHEMBL3718063 | 2-Chloro-1-(4-fluoro-benzyl)-1H-benzoimidazole | 2-Chloro-1-(4-fluorobenzyl)-1H-benzoimidazo...
  8. 2-Chloro-1-(4-fluorobenzyl)benzimidazole
    CAS: 84946-20-3 Formula: C14H10ClFN2 Molecular Weight: 260.69
    10mM in DMSO
    ◐ .Made to order · 8–12 wks Item #: C426241
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    Technical Identifiers
    IUPAC Name
    2-chloro-1-[(4-fluorophenyl)methyl]benzimidazole
    SMILES
    C1=CC=C2C(=C1)N=C(N2CC3=CC=C(C=C3)F)Cl
    InChIKey
    PGXALMVNIRPELS-UHFFFAOYSA-N
    InChI
    1S/C14H10ClFN2/c15-14-17-12-3-1-2-4-13(12)18(14)9-10-5-7-11(16)8-6-10/h1-8H,9H2
    Synonyms
    C2850 | SCHEMBL3718063 | 2-Chloro-1-(4-fluoro-benzyl)-1H-benzoimidazole | 2-Chloro-1-(4-fluorobenzyl)-1H-benzoimidazo...
  9. 4'-Hydroxyflavone
    CAS: 4143-63-9 EC Number: 835-257-5 Formula: C15H10O3 Molecular Weight: 238.24
    ● In Stock — US warehouse, ships to EU* Item #: H303679
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    IUPAC Name
    2-(4-hydroxyphenyl)chromen-4-one
    SMILES
    C1=CC=C2C(=C1)C(=O)C=C(O2)C3=CC=C(C=C3)O
    InChIKey
    SHGLJXBLXNNCTE-UHFFFAOYSA-N
    InChI
    1S/C15H10O3/c16-11-7-5-10(6-8-11)15-9-13(17)12-3-1-2-4-14(12)18-15/h1-9,16H
    Synonyms
    Flavone, 4'-hydroxy- | 4-OXO-4-(2-OXO-1,2-DIPHENYLETHOXY)BUTANOICACID | ChemDiv2_003923 | Q27270572 | SR-01000471683 ...
  10. AKR1C1-IN-1
    CAS: 4906-68-7 Formula: C13H9BrO3 Molecular Weight: 293.12
    ● In Stock — US warehouse, ships to EU* Item #: A412533
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    IUPAC Name
    3-bromo-2-hydroxy-5-phenylbenzoic acid
    SMILES
    C1=CC=C(C=C1)C2=CC(=C(C(=C2)Br)O)C(=O)O
    InChIKey
    XVZSXNULHSIRCQ-UHFFFAOYSA-N
    InChI
    1S/C13H9BrO3/c14-11-7-9(8-4-2-1-3-5-8)6-10(12(11)15)13(16)17/h1-7,15H,(H,16,17)
    Synonyms
    HY-114009 | 3-Bromo-5-phenylsalicylc acid | E76500 | S0764 | 3-Bromo-5-phenyl salicylic acid | AKOS005151372 | 3-brom...
  11. AKR1C1-IN-1
    CAS: 4906-68-7 Formula: C13H9BrO3 Molecular Weight: 293.12
    10mM in DMSO
    ◐ .Made to order · 8–12 wks Item #: A424246
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    Technical Identifiers
    IUPAC Name
    3-bromo-2-hydroxy-5-phenylbenzoic acid
    SMILES
    C1=CC=C(C=C1)C2=CC(=C(C(=C2)Br)O)C(=O)O
    InChIKey
    XVZSXNULHSIRCQ-UHFFFAOYSA-N
    InChI
    1S/C13H9BrO3/c14-11-7-9(8-4-2-1-3-5-8)6-10(12(11)15)13(16)17/h1-7,15H,(H,16,17)
    Synonyms
    HY-114009 | 3-Bromo-5-phenylsalicylc acid | E76500 | S0764 | 3-Bromo-5-phenyl salicylic acid | AKOS005151372 | 3-brom...
  12. AT-001, Aldose reductase inhibitor
    CAS: 1355612-71-3 Formula: C17H10F3N5O3S Molecular Weight: 421.35
    ● In Stock — US warehouse, ships to EU* Item #: A412602
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    IUPAC Name
    2-[5-oxo-6-[[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl]pyrazino[2,3-d]pyridazin-8-yl]acetic acid
    SMILES
    C1=CC2=C(C=C1C(F)(F)F)N=C(S2)CN3C(=O)C4=NC=CN=C4C(=N3)CC(=O)O
    InChIKey
    YRGPAXAVTDMKDK-UHFFFAOYSA-N
    InChI
    1S/C17H10F3N5O3S/c18-17(19,20)8-1-2-11-9(5-8)23-12(29-11)7-25-16(28)15-14(21-3-4-22-15)10(24-25)6-13(26)27/h1-5H,6-7H2,(H,26,27)
    Synonyms
    Caficrestat | 2-(8-Oxo-7-((5-(trifluoromethyl)benzo[d]thiazol-2-yl)methyl)-7,8-dihydropyrazino[2,3-d]pyridazin-5-yl)a...
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Frequently Asked Questions

Which compounds are listed for Aldose Reductase?
Compounds associated with Aldose Reductase are grouped here under the Metabolic Enzyme/Protease classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.
How does Aldose Reductase sit within Metabolic Enzyme/Protease?
Aldose Reductase is one target listing within the Metabolic Enzyme/Protease classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.
What data should I check before ordering a compound from Aldose Reductase?
For compounds listed under Aldose Reductase, check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
How do I find related targets or backup compounds for Aldose Reductase?
Browse the parent Metabolic Enzyme/Protease listing to reach targets neighbouring Aldose Reductase, and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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