Protein Tyrosine Kinase/RTK - Anaplastic lymphoma kinase (ALK) Supplier | High Purity

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TL 13-112, Inhibitor of ALK receptor tyrosine kinase
CAS: 2229037-19-6 PubChem CID: 138108958 Formula: C₄₉H₆₀ClN₉O₁₀S Molecular Weight: 1002.57

Moligand™ ? ≥97%

● In Stock — US warehouse, ships to EU* Item #: T287746
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IUPAC Name

N-[2-[2-[2-[4-[4-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-2-methyl-5-propan-2-yloxyphenyl]piperidin-1-yl]ethoxy]ethoxy]ethyl]-show more

SMILES

CC1=CC(=C(C=C1C2CCN(CC2)CCOCCOCCNC(=O)CNC3=CC=CC4=C3C(=O)N(C4=O)C5CCC(=O)NC5=O)OC(C)C)NC6=NC=C(C(=N6)NC7=CC=CC=C7S(=O)(=O)C(C)C)Cl

InChIKey
XIRQUXILNXIWDI-UHFFFAOYSA-N

InChI

1S/C49H60ClN9O10S/c1-29(2)69-40-26-34(31(5)25-38(40)55-49-53-27-35(50)45(57-49)54-36-10-6-7-12-41(36)70(65,66)30(3)4)32-15-18-58(19-16-32)20-22-68-24-show more

Synonyms
N-[2-[2-[2-[4-[4-[[5-Chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-2-methyl-5-(1-methyleth...
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TL 13-12
CAS: 2229037-04-9 PubChem CID: 138108740 Formula: C₄₅H₅₃ClN₁₀O₁₀S Molecular Weight: 961.48

≥98%(HPLC)

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IUPAC Name

N-[2-[2-[2-[4-[4-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-3-methoxyphenyl]piperazin-1-yl]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxoshow more

SMILES

CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCN(CC4)CCOCCOCCNC(=O)CNC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)OC

InChIKey
WXNUIPVZMJMPNM-UHFFFAOYSA-N

InChI

1S/C45H53ClN10O10S/c1-28(2)67(62,63)37-10-5-4-8-33(37)50-41-31(46)26-49-45(53-41)51-32-12-11-29(25-36(32)64-3)55-18-16-54(17-19-55)20-22-66-24-23-65-2show more

Synonyms
N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-y...
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TL 13-22
CAS: 2229036-65-9 PubChem CID: 138991783 Formula: C₄₅H₅₅ClN₁₀O₉S Molecular Weight: 947.5

≥98%(HPLC)

◐ .Made to order · 8–12 wks Item #: T288725
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Technical Identifiers

IUPAC Name

N-[2-[2-[2-[4-[4-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-3-methoxyphenyl]piperazin-1-yl]ethoxy]ethoxy]ethyl]-2-[[1,3-dioxo-2-show more

SMILES

CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCN(CC4)CCOCCOCCNC(=O)CNC5=CC=CC6=C5C(=O)N(C6=O)C7CCCNC7=O)OC

InChIKey
JVBGYTWMZKXATO-UHFFFAOYSA-N

InChI

1S/C45H55ClN10O9S/c1-29(2)66(61,62)38-12-5-4-9-34(38)51-41-32(46)27-50-45(53-41)52-33-14-13-30(26-37(33)63-3)55-19-17-54(18-20-55)21-23-65-25-24-64-22show more

Synonyms
N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-y...
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LDK378, NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)
CAS: 1032900-25-6 EC Number: 811-457-8 Formula: C₂₈H₃₆ClN₅O₃S Molecular Weight: 558.14

Moligand™ ? ≥99%

● In Stock — US warehouse, ships to EU* Item #: L127618
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Technical Identifiers

IUPAC Name

5-chloro-2-N-(5-methyl-4-piperidin-4-yl-2-propan-2-yloxyphenyl)-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine

SMILES

CC1=CC(=C(C=C1C2CCNCC2)OC(C)C)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)C(C)C)Cl

InChIKey
VERWOWGGCGHDQE-UHFFFAOYSA-N

InChI

1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,3show more

Synonyms
K418KG2GET | 5-chloro-2-N-[5-methyl-4-(piperidin-4-yl)-2-(propan-2-yloxy)phenyl]-4-N-[2-(propane-2-sulfonyl)phenyl]py...
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AZD3463, Inhibitor of ALK receptor tyrosine kinase;Inhibitor of Insulin-like growth factor I receptor
CAS: 1356962-20-3 Formula: C₂₄H₂₅ClN₆O Molecular Weight: 448.95

Moligand™ ? ≥98%

● In Stock — US warehouse, ships to EU* Item #: A125664
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IUPAC Name

N-[4-(4-aminopiperidin-1-yl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine

SMILES

COC1=C(C=CC(=C1)N2CCC(CC2)N)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl

InChIKey
GCYIGMXOIWJGBU-UHFFFAOYSA-N

InChI

1S/C24H25ClN6O/c1-32-22-12-16(31-10-8-15(26)9-11-31)6-7-21(22)29-24-28-14-19(25)23(30-24)18-13-27-20-5-3-2-4-17(18)20/h2-7,12-15,27H,8-11,26H2,1H3,(H,show more

Synonyms
BCP07685 | Q27074737 | CI 37550 | DTXSID50717792 | HMS3653G05 | N-(4-(4-Aminopiperidin-1-yl)-2-methoxyphenyl)-5-chlor...
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AP26113
CAS: 1197958-12-5 Formula: C₂₆H₃₄ClN₆O₂P Molecular Weight: 529.01

≥98%

● In Stock — US warehouse, ships to EU* Item #: A127691
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IUPAC Name

5-chloro-2-N-[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl]-4-N-(2-dimethylphosphorylphenyl)pyrimidine-2,4-diamine

SMILES

CN(C)C1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=CC=C4P(=O)(C)C)Cl)OC

InChIKey
OVDSPTSBIQCAIN-UHFFFAOYSA-N

InChI

1S/C26H34ClN6O2P/c1-32(2)18-12-14-33(15-13-18)19-10-11-21(23(16-19)35-3)30-26-28-17-20(27)25(31-26)29-22-8-6-7-9-24(22)36(4,5)34/h6-11,16-18H,12-15H2,show more

Synonyms
5-Chloro-N2-[4-[4-(dimethylamino)-1-piperidinyl]-2-methoxyphenyl]-N4-[2-(dimethylphosphinyl)phenyl]-2,4-pyrimidinedia...
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ASP3026, ALK tyrosine kinase receptor inhibitor
CAS: 1097917-15-1 Formula: C₂₉H₄₀N₈O₃S Molecular Weight: 580.74

Moligand™ ? ≥98%

● In Stock — US warehouse, ships to EU* Item #: A128022
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IUPAC Name

2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine

SMILES

CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=N2)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC

InChIKey
MGGBYMDAPCCKCT-UHFFFAOYSA-N

InChI

1S/C29H40N8O3S/c1-21(2)41(38,39)27-8-6-5-7-25(27)33-29-31-20-30-28(34-29)32-24-10-9-23(19-26(24)40-4)36-13-11-22(12-14-36)37-17-15-35(3)16-18-37/h5-10show more

Synonyms
F6O | SMR004702945 | UNII-HP4L6MXF10 | XTB91715 | NCGC00345791-01 | N2-(2-(isopropylsulfonyl)phenyl)-N4-(2-methoxy-4-...
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Entrectinib, ALK tyrosine kinase receptor inhibitor
CAS: 1108743-60-7 EC Number: 816-298-8 Formula: C₃₁H₃₄F₂N₆O₂ Molecular Weight: 560.64

Moligand™ ? ≥98%

● In Stock — US warehouse, ships to EU* Item #: E302199
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Technical Identifiers

IUPAC Name

N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(oxan-4-ylamino)benzamide

SMILES

CN1CCN(CC1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)NC6CCOCC6

InChIKey
HAYYBYPASCDWEQ-UHFFFAOYSA-N

InChI

1S/C31H34F2N6O2/c1-38-8-10-39(11-9-38)25-3-4-26(29(19-25)34-24-6-12-41-13-7-24)31(40)35-30-27-17-20(2-5-28(27)36-37-30)14-21-15-22(32)18-23(33)16-21/hshow more

Synonyms
DB11986 | RXDX 101 | ENTRECTINIB [WHO-DD] | RG 6268 | NCGC00484067-01 | NCGC00484067-02 | NSC774769 | NSC-774769 | N-...
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TAE684 (NVP-TAE684), Inhibitor of ALK receptor tyrosine kinase
CAS: 761439-42-3 PubChem CID: 16038120 Formula: C₃₀H₄₀ClN₇O₃S Molecular Weight: 614.2

Moligand™ ? ≥98%

● In Stock — US warehouse, ships to EU* Item #: T129819
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Technical Identifiers

IUPAC Name

5-chloro-2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine

SMILES

CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC

InChIKey
QQWUGDVOUVUTOY-UHFFFAOYSA-N

InChI

1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/show more

Synonyms
5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-pyperidinyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-Pyrimidinediamine | 5...
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KRCA 0008
CAS: 1472795-20-2 Formula: C₃₀H₃₇ClN₈O₄ Molecular Weight: 609.12

≥98%

● In Stock — US warehouse, ships to EU* Item #: K287624
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IUPAC Name

1-[4-[4-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxyanilino]-5-chloropyrimidin-4-yl]amino]-3-methoxyphenyl]piperazin-1-yl]ethanone

SMILES

CC(=O)N1CCN(CC1)C2=CC(=C(C=C2)NC3=NC(=NC=C3Cl)NC4=C(C=C(C=C4)N5CCN(CC5)C(=O)C)OC)OC

InChIKey
TXDIRJCYNAWBOS-UHFFFAOYSA-N

InChI

1S/C30H37ClN8O4/c1-20(40)36-9-13-38(14-10-36)22-5-7-25(27(17-22)42-3)33-29-24(31)19-32-30(35-29)34-26-8-6-23(18-28(26)43-4)39-15-11-37(12-16-39)21(2)4show more

Synonyms
1,1'-[(5-Chloro-2,4-pyrimidinediyl)bis[imino(3-methoxy-4,1-phenylene)-4,1-piperazinediyl]]bisethanone
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R 268712
CAS: 879487-87-3 PubChem CID: 11703284 Formula: C₂₀H₁₈FN₅O Molecular Weight: 363.39

≥98%(HPLC)

● In Stock — US warehouse, ships to EU* Item #: R286557
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IUPAC Name

2-[4-[2-fluoro-5-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]phenyl]pyrazol-1-yl]ethanol

SMILES

CC1=NC(=CC=C1)C2=C(C=NN2)C3=CC(=C(C=C3)F)C4=CN(N=C4)CCO

InChIKey
JQGOCCALXFSRHZ-UHFFFAOYSA-N

InChI

1S/C20H18FN5O/c1-13-3-2-4-19(24-13)20-17(11-22-25-20)14-5-6-18(21)16(9-14)15-10-23-26(12-15)7-8-27/h2-6,9-12,27H,7-8H2,1H3,(H,22,25)

Synonyms
SCHEMBL5198271 | C20H18FN5O | NCGC00387472-01 | 4-[2-Fluoro-5-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]phenyl]-1H-py...
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Lorlatinib, EML4-ALK inhibitor
CAS: 1454846-35-5 EC Number: 813-704-5 PubChem CID: 71731823 Formula: C₂₁H₁₉FN₆O₂ Molecular Weight: 406.41

Solid Moligand™ ? ≥98%(HPLC)

● In Stock — US warehouse, ships to EU* Item #: P167337
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IUPAC Name

(16R)-19-amino-13-fluoro-4,8,16-trimethyl-9-oxo-17-oxa-4,5,8,20-tetrazatetracyclo[16.3.1.02,6.010,15]docosa-1(22),2,5,10(15),11,13,18,20-octaene-3-carshow more

SMILES

CC1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C

InChIKey
IIXWYSCJSQVBQM-LLVKDONJSA-N

InChI

1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/show more

Synonyms
(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-4,8-methenopyrazolo(4,3-h)(2,5,11)benzoxad...

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Frequently Asked Questions

Which compounds are listed for Anaplastic lymphoma kinase (ALK)?

Compounds associated with Anaplastic lymphoma kinase (ALK) are grouped here under the Protein Tyrosine Kinase/RTK classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.

How does Anaplastic lymphoma kinase (ALK) sit within Protein Tyrosine Kinase/RTK?

Anaplastic lymphoma kinase (ALK) is one target listing within the Protein Tyrosine Kinase/RTK classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.

What data should I check before ordering a compound from Anaplastic lymphoma kinase (ALK)?

For compounds listed under Anaplastic lymphoma kinase (ALK), check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.

How do I find related targets or backup compounds for Anaplastic lymphoma kinase (ALK)?

Browse the parent Protein Tyrosine Kinase/RTK listing to reach targets neighbouring Anaplastic lymphoma kinase (ALK), and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.