c-Met/HGFR

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  1. Foretinib (GSK1363089), Vascular endothelial growth factor receptor inhibitor
    CAS: 849217-64-7 EC Number: 629-893-0 Formula: C34H34F2N4O6 Molecular Weight: 632.65
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: F127011
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    IUPAC Name
    1-N'-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
    SMILES
    COC1=CC2=C(C=CN=C2C=C1OCCCN3CCOCC3)OC4=C(C=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F
    InChIKey
    CXQHYVUVSFXTMY-UHFFFAOYSA-N
    InChI
    1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3show more
    Synonyms
    81FH7VK1C4 | Foretinib [USAN:INN] | N-(3-FLUORO-4-((6-METHOXY-7-(3-(MORPHOLIN-4-YL)PROPOXY)QUINOLIN-4-YL)OXY) PHENYL)...
  2. PF 04217903 mesylate
    CAS: 956906-93-7 PubChem CID: 24852079 Formula: C20H20N8O4S Molecular Weight: 468.49
    ◐ .Made to order · 8–12 wks Item #: P288839
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    IUPAC Name
    methanesulfonic acid;2-[4-[3-(quinolin-6-ylmethyl)triazolo[4,5-b]pyrazin-5-yl]pyrazol-1-yl]ethanol
    SMILES
    CS(=O)(=O)O.C1=CC2=C(C=CC(=C2)CN3C4=NC(=CN=C4N=N3)C5=CN(N=C5)CCO)N=C1
    InChIKey
    HBEMHKVWZJTVOC-UHFFFAOYSA-N
    InChI
    1S/C19H16N8O.CH4O3S/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16;1-5(2,3)4/h1-5,8-10,12,28H,6-7,11H2;1H3show more
    Synonyms
    2-(4-{1-[(quinolin-6-yl)methyl]-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl}-1H-pyrazol-1-yl)ethan-1-ol; methanesulfonic ac...
  3. SJF 8240
    CAS: 2230821-68-6 PubChem CID: 135175904 Formula: C₅₈H₆₅F₂N₇O₁₁S Molecular Weight: 1106.25
    ◐ .Made to order · 8–12 wks Item #: S286553
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    SMILES
    COC1=CC2=C(N=CC=C2OC3=C(C=C(C=C3)NC(C4(C(NC5=CC=C(C=C5)F)=O)CC4)=O)F)C=C1OCCCOCCCOCCC(N[C@@H](C(C)(C)C)C(N6C[C@@H](C[C@H]6C(NCC7=CC=C(C8=C(N=CS8)C)C=Cshow more
    InChIKey
    SCUZPTNDZHEHLB-ZWUDBOSPSA-N
    Synonyms
    N-(3-Fluoro-4-((7-(3-(3-(3-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3...
  4. MK-2461, Hepatocyte growth factor receptor inhibitor
    CAS: 917879-39-1 Formula: C24H25N5O5S Molecular Weight: 495.55
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: M129777
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    IUPAC Name
    14-[[[(2R)-1,4-dioxan-2-yl]methyl-methylsulfamoyl]amino]-5-(1-methylpyrazol-4-yl)-2-oxo-7-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptshow more
    SMILES
    CN1C=C(C=N1)C2=CC3=C(C=CC4=C(C3=O)C=C(C=C4)NS(=O)(=O)N(C)CC5COCCO5)N=C2
    InChIKey
    JGEBLDKNWBUGRZ-HXUWFJFHSA-N
    InChI
    1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14show more
    Synonyms
    SCHEMBL93526 | NCGC00346695-05 | CCG-264723 | FT-0631528 | NSC800795 | NSC-800795 | EX-A1566 | SY003220 | UNII-4200RD...
  5. SGX-523, Hepatocyte growth factor receptor inhibitor
    CAS: 1022150-57-7 PubChem CID: 24779724 Formula: C18H13N7S Molecular Weight: 359.42
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: S127194
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    IUPAC Name
    6-[[6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]quinoline
    SMILES
    CN1C=C(C=N1)C2=NN3C(=NN=C3SC4=CC5=C(C=C4)N=CC=C5)C=C2
    InChIKey
    BCZUAADEACICHN-UHFFFAOYSA-N
    InChI
    1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3
    Synonyms
    6-((6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)quinoline | AKOS025117577 | NCGC00263163-0...
  6. PHA-665752, Inhibitor of MET proto-oncogene; receptor tyrosine kinase
    CAS: 477575-56-7 Formula: C32H34Cl2N4O4S Molecular Weight: 641.61
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: P125191
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    IUPAC Name
    (3Z)-5-[(2,6-dichlorophenyl)methylsulfonyl]-3-[[3,5-dimethyl-4-[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl]-1H-pyrrol-2-yl]methylidene]-1H-ishow more
    SMILES
    CC1=C(NC(=C1C(=O)N2CCCC2CN3CCCC3)C)C=C4C5=C(C=CC(=C5)S(=O)(=O)CC6=C(C=CC=C6Cl)Cl)NC4=O
    InChIKey
    OYONTEXKYJZFHA-SSHUPFPWSA-N
    InChI
    1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27show more
    Synonyms
    PHA-665752 hydrate | (3Z)-5-{[(2,6-dichlorophenyl)methane]sulfonyl}-3-[(3,5-dimethyl-4-{[(2R)-2-(pyrrolidin-1-ylmethy...
  7. BMS-794833, Inhibitor of MER proto-oncogene; tyrosine kinase
    CAS: 1174046-72-0 Formula: C23H15ClF2N4O3 Molecular Weight: 468.84
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: B129768
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    IUPAC Name
    N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1H-pyridine-3-carboxamide
    SMILES
    C1=CC(=CC=C1C2=CNC=C(C2=O)C(=O)NC3=CC(=C(C=C3)OC4=C(C(=NC=C4)N)Cl)F)F
    InChIKey
    PDYXPCKITKHFOZ-UHFFFAOYSA-N
    InChI
    1S/C23H15ClF2N4O3/c24-20-19(7-8-29-22(20)27)33-18-6-5-14(9-17(18)26)30-23(32)16-11-28-10-15(21(16)31)12-1-3-13(25)4-2-12/h1-11H,(H2,27,29)(H,28,31)(H,show more
    Synonyms
    SCHEMBL13770016 | J-690046 | HY-10497 | AC-32814 | BDBM50146164 | BMS 794833 | 1174046-72-0 | SMR004702756 | metatini...
  8. PF-04217903, Hepatocyte growth factor receptor inhibitor
    CAS: 956905-27-4 Formula: C19H16N8O Molecular Weight: 372.38
    ● In Stock — US warehouse, ships to EU* Item #: P127567
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    IUPAC Name
    2-[4-[3-(quinolin-6-ylmethyl)triazolo[4,5-b]pyrazin-5-yl]pyrazol-1-yl]ethanol
    SMILES
    C1=CC2=C(C=CC(=C2)CN3C4=NC(=CN=C4N=N3)C5=CN(N=C5)CCO)N=C1
    InChIKey
    PDMUGYOXRHVNMO-UHFFFAOYSA-N
    InChI
    1S/C19H16N8O/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16/h1-5,8-10,12,28H,6-7,11H2
    Synonyms
    2-(4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]triazolo[4,5-b]pyrazin-5-yl)-1H-pyrazol-1-yl)ethanol | 2-[4-[1-(Quinolin-6-yl...
  9. CEP-40783
    CAS: 1437321-24-8 Formula: C31H26F2N4O6 Molecular Weight: 588.6
    ● In Stock — US warehouse, ships to EU* Item #: C174233
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    IUPAC Name
    N-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
    SMILES
    CC(C)N1C=C(C(=O)N(C1=O)C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C5C=C(C(=CC5=NC=C4)OC)OC)F
    InChIKey
    FKCWHHYUMFGOPY-UHFFFAOYSA-N
    InChI
    1S/C31H26F2N4O6/c1-17(2)36-16-22(30(39)37(31(36)40)20-8-5-18(32)6-9-20)29(38)35-19-7-10-26(23(33)13-19)43-25-11-12-34-24-15-28(42-4)27(41-3)14-21(24)2show more
    Synonyms
    AS-35141 | N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-te...
  10. NVP-BVU972
    CAS: 1185763-69-2 Formula: C20H16N6 Molecular Weight: 340.38
    ● In Stock — US warehouse, ships to EU* Item #: N128061
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    IUPAC Name
    6-[[6-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]quinoline
    SMILES
    CN1C=C(C=N1)C2=NN3C(=NC=C3CC4=CC5=C(C=C4)N=CC=C5)C=C2
    InChIKey
    RNCNPRCUHHDYPC-UHFFFAOYSA-N
    InChI
    1S/C20H16N6/c1-25-13-16(11-23-25)19-6-7-20-22-12-17(26(20)24-19)10-14-4-5-18-15(9-14)3-2-8-21-18/h2-9,11-13H,10H2,1H3
    Synonyms
    NCGC00346689-02 | (.+/-.)-2-Ethyloxirane | Allylglycide ether | BDBM50146169 | MLS006010964 | AS-56284 | C71592 | RNC...
  11. LY2801653, Hepatocyte growth factor receptor inhibitor
    CAS: 1206799-15-6 EC Number: 806-589-8 Formula: C30H22F2N6O3 Molecular Weight: 552.53
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: L127298
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    IUPAC Name
    N-[3-fluoro-4-[1-methyl-6-(1H-pyrazol-4-yl)indazol-5-yl]oxyphenyl]-1-(4-fluorophenyl)-6-methyl-2-oxopyridine-3-carboxamide
    SMILES
    CC1=CC=C(C(=O)N1C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C(C=C5C(=C4)C=NN5C)C6=CNN=C6)F
    InChIKey
    QHADVLVFMKEIIP-UHFFFAOYSA-N
    InChI
    1S/C30H22F2N6O3/c1-17-3-9-23(30(40)38(17)22-7-4-20(31)5-8-22)29(39)36-21-6-10-27(25(32)12-21)41-28-11-18-16-35-37(2)26(18)13-24(28)19-14-33-34-15-19/hshow more
    Synonyms
    2,2'-Dithiobis[benzothiazole] | SCHEMBL2716 | s7014 | NSC800788 | NSC-800788 | CCG-270011 | LY 2801653 | BDBM50172078...
  12. 7-Methoxy-1-tetralone
    CAS: 6836-19-7 EC Number: 229-916-0 Formula: C11H12O2 Molecular Weight: 176.21
    ● In Stock — Germany Item #: M119779
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    IUPAC Name
    7-methoxy-3,4-dihydro-2H-naphthalen-1-one
    SMILES
    COC1=CC2=C(CCCC2=O)C=C1
    InChIKey
    GABLTKRIYDNDIN-UHFFFAOYSA-N
    InChI
    1S/C11H12O2/c1-13-9-6-5-8-3-2-4-11(12)10(8)7-9/h5-7H,2-4H2,1H3
    Synonyms
    7-methoxy-3,4-dihydro-2H-naphthalen-1-one | 7-methoxytetralone | 7-methoxy-tetralone | HY-W001925 | 7-methoxy-1,2,3,4...
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Frequently Asked Questions

What can I find under c-Met/HGFR?
This listing collects compounds associated with c-Met/HGFR within our Protein Tyrosine Kinase/RTK area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.
What should I consider when picking a compound for c-Met/HGFR?
Consider the reported potency of each c-Met/HGFR compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.
What quality information is provided for c-Met/HGFR compounds?
Each c-Met/HGFR product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search c-Met/HGFR compounds by activity or structure?
Yes. Filter the c-Met/HGFR listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].

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