Dihydrofolate reductase (DHFR)
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46 products
Popular Products
- 10-Formyl Folic AcidCAS: 134-05-4 Formula: C20H19N7O7 Molecular Weight: 469.41● In Stock — US warehouse, ships to EU* Item #: F334434View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (2S)-2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methyl-formylamino]benzoyl]amino]pentanedioic acid
- SMILES
- C1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)N(CC2=CN=C3C(=N2)C(=O)NC(=N3)N)C=O
- InChIKey
- UGWUWNVTCLDEOG-ZDUSSCGKSA-N
- InChI
- show more
- Synonyms
- 10-Formylpteroylglutamic Acid | 10-Formyldihydropteroylglutamate | L-GLUTAMIC ACID, N-(4-(((2-AMINO-3,4-DIHYDRO-4-OXO...
- 6-(Diethylamino)-2,3-dihydrophthalazine-1,4-dioneCAS: 29415-71-2 Formula: C12H15N3O2 Molecular Weight: 233.272● In Stock — US warehouse, ships to EU* Item #: D169337View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 6-(diethylamino)-2,3-dihydrophthalazine-1,4-dione
- SMILES
- CCN(CC)C1=CC2=C(C=C1)C(=O)NNC2=O
- InChIKey
- WNYLSNZNCJLARI-UHFFFAOYSA-N
- InChI
- 1S/C12H15N3O2/c1-3-15(4-2)8-5-6-9-10(7-8)12(17)14-13-11(9)16/h5-7H,3-4H2,1-2H3,(H,13,16)(H,14,17)
- Synonyms
- 6-(Diethylamino)phthalazine-1,4-diol | STK408922 | SCHEMBL3780116 | HMS1547I17 | SR-01000448030-1 | 6-(diethylamino)-...
- 4-O-Methyldopamine hydrochlorideCAS: 645-33-0 Formula: C9H14NO2Cl Molecular Weight: 203.7● In Stock — US warehouse, ships to EU* Item #: H185776View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 5-(2-aminoethyl)-2-methoxyphenol;hydrochloride
- SMILES
- COC1=C(C=C(C=C1)CCN)O.Cl
- InChIKey
- KAAFITWSSODFMA-UHFFFAOYSA-N
- InChI
- 1S/C9H13NO2.ClH/c1-12-9-3-2-7(4-5-10)6-8(9)11;/h2-3,6,11H,4-5,10H2,1H3;1H
- Synonyms
- 3-Hydroxy-4-methoxyphenethylamine hydrochloride
- 4-[N-(2,4-Diamino-6-pteridinylmethyl)-N-methylamino]benzoic acidCAS: 19741-14-1 Formula: C15H15N7O2 Molecular Weight: 325.33● In Stock — US warehouse, ships to EU* Item #: N467541View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoic acid
- SMILES
- CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)O
- InChIKey
- LWCXZSDKANNOAR-UHFFFAOYSA-N
- InChI
- 1S/C15H15N7O2/c1-22(10-4-2-8(3-5-10)14(23)24)7-9-6-18-13-11(19-9)12(16)20-15(17)21-13/h2-6H,7H2,1H3,(H,23,24)(H4,16,17,18,20,21)
- Synonyms
- DTXSID20173427 | MFCD00075774 | a-naphthoquinone | 4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzoicacid | C...
- epiroprimCAS: 73090-70-7 PubChem CID: 68916Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.◐ .Made to order · 8–12 wks Item #: E610163View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 5-[(3,5-diethoxy-4-pyrrol-1-ylphenyl)methyl]pyrimidine-2,4-diamine
- SMILES
- CCOc1cc(cc(c1n1cccc1)OCC)Cc1cnc(nc1N)N
- InChIKey
- NMARPFMJVCXSAV-UHFFFAOYSA-N
- InChI
- 1S/C19H23N5O2/c1-3-25-15-10-13(9-14-12-22-19(21)23-18(14)20)11-16(26-4-2)17(15)24-7-5-6-8-24/h5-8,10-12H,3-4,9H2,1-2H3,(H4,20,21,22,23)
- Synonyms
- Epiroprima | GTPL12327 | Epiroprime [INN-French] | 2,4-Diamino-5-(3,5-diethoxy-4-pyrrol-1-ylbenzyl)pyrimidine | BRN 4...
- piritrexim, Dihydrofolate reductase inhibitorMoligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.◐ .Made to order · 8–12 wks Item #: P612847View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine
- SMILES
- CC1=C2C(=NC(=NC2=NC=C1CC3=C(C=CC(=C3)OC)OC)N)N
- InChIKey
- VJXSSYDSOJBUAV-UHFFFAOYSA-N
- InChI
- 1S/C17H19N5O2/c1-9-11(6-10-7-12(23-2)4-5-13(10)24-3)8-20-16-14(9)15(18)21-17(19)22-16/h4-5,7-8H,6H2,1-3H3,(H4,18,19,20,21,22)
- Synonyms
- 6-(2,5-DIMETHOXY-BENZYL)-5-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE | 6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]...
- trimetrexate, Inhibitor of dihydrofolate reductaseMoligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.◐ .Made to order · 8–12 wks Item #: T614542View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline-2,4-diamine
- SMILES
- CC1=C(C=CC2=C1C(=NC(=N2)N)N)CNC3=CC(=C(C(=C3)OC)OC)OC
- InChIKey
- NOYPYLRCIDNJJB-UHFFFAOYSA-N
- InChI
- 1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24)
- Synonyms
- Jb-11 | NCGC00161419-03 | TRIMETREXATE [USAN] | 5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}quinazoline-2,4-dia...
- WR99210Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%◐ .Made to order · 8–12 wks Item #: W649288View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,3,5-triazine-2,4-diamine
- SMILES
- CC1(N=C(N=C(N1OCCCOC2=CC(=C(C=C2Cl)Cl)Cl)N)N)C
- InChIKey
- MJZJYWCQPMNPRM-UHFFFAOYSA-N
- InChI
- 1S/C14H18Cl3N5O2/c1-14(2)21-12(18)20-13(19)22(14)24-5-3-4-23-11-7-9(16)8(15)6-10(11)17/h6-7H,3-5H2,1-2H3,(H4,18,19,20,21)
- Synonyms
- 6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,3,5-triazinane-2,4-diimine | DTXSID30952947 | WR-99,210 | Alumin...
- 4-((2，4-Diaminopyrimidin-5-yl)methyl)-2，6-dimethoxyphenol◐ .Made to order · 8–12 wks Item #: M724729View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 4-[(2,4-diaminopyrimidin-5-yl)methyl]-2,6-dimethoxyphenol
- SMILES
- COC1=CC(=CC(=C1O)OC)CC2=CN=C(N=C2N)N
- InChIKey
- HPOCGNHBIFZCAN-UHFFFAOYSA-N
- InChI
- 1S/C13H16N4O3/c1-19-9-4-7(5-10(20-2)11(9)18)3-8-6-16-13(15)17-12(8)14/h4-6,18H,3H2,1-2H3,(H4,14,15,16,17)
- TalotrexinCAS: 113857-87-7 Formula: C27H27N9O6 Molecular Weight: 573.6◐ .Made to order · 8–12 wks Item #: T1356280View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 2-[[(4S)-4-carboxy-4-[[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoyl]amino]butyl]carbamoyl]benzoic acid
- SMILES
- C1=CC=C(C(=C1)C(=O)NCCC[C@@H](C(=O)O)NC(=O)C2=CC=C(C=C2)NCC3=CN=C4C(=N3)C(=NC(=N4)N)N)C(=O)O
- InChIKey
- NYQPLPNEESYGNO-IBGZPJMESA-N
- InChI
- show more
- Talotrexin AmmoniumCAS: 648420-92-2 Formula: C27H30N10O6 Molecular Weight: 590.600◐ .Made to order · 8–12 wks Item #: T941347View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- azane;2-[[(4S)-4-carboxy-4-[[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoyl]amino]butyl]carbamoyl]benzoic acid
- SMILES
- C1=CC=C(C(=C1)C(=O)NCCC[C@@H](C(=O)O)NC(=O)C2=CC=C(C=C2)NCC3=CN=C4C(=N3)C(=NC(=N4)N)N)C(=O)O.N
- InChIKey
- CURXCENNYPPKOS-FYZYNONXSA-N
- InChI
- show more
- ChlorasquinCAS: 18921-73-8 Formula: C20H19ClN6O5 Molecular Weight: 458.86◐ .Made to order · 8–12 wks Item #: C1424706View ProductPricing & Pack Sizes
Technical Identifiers
![4-[N-(2,4-Diamino-6-pteridinylmethyl)-N-methylamino]benzoic acid](https://www.aladdinsci.com/media/catalog/product/cache/6360e336b2a70951114dbd37294096ee/N/4/N467541.png)
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R&D Use Only Products supplied for research and development use
Frequently Asked Questions
What can I find under Dihydrofolate reductase (DHFR)?
This listing collects compounds associated with Dihydrofolate reductase (DHFR) within our Metabolic Enzyme/Protease area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.
What should I consider when picking a compound for Dihydrofolate reductase (DHFR)?
Consider the reported potency of each Dihydrofolate reductase (DHFR) compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.
What quality information is provided for Dihydrofolate reductase (DHFR) compounds?
Each Dihydrofolate reductase (DHFR) product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search Dihydrofolate reductase (DHFR) compounds by activity or structure?
Yes. Filter the Dihydrofolate reductase (DHFR) listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].