DNA-PK

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  1. Nedisertib (M3814), Inhibitor of protein kinase; DNA-activated; catalytic subunit
    CAS: 1637542-33-6 Formula: C24H21ClFN5O3 Molecular Weight: 481.91
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ● In Stock — US warehouse, ships to EU* Item #: N414073
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    IUPAC Name
    (S)-[2-chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxypyridazin-3-yl)methanol
    SMILES
    COC1=NN=C(C=C1)C(C2=C(C=C(C(=C2)C3=NC=NC4=C3C=CC(=C4)N5CCOCC5)F)Cl)O
    InChIKey
    MOWXJLUYGFNTAL-DEOSSOPVSA-N
    InChI
    1S/C24H21ClFN5O3/c1-33-22-5-4-20(29-30-22)24(32)16-11-17(19(26)12-18(16)25)23-15-3-2-14(10-21(15)27-13-28-23)31-6-8-34-9-7-31/h2-5,10-13,24,32H,6-9H2,show more
    Synonyms
    1IX | MSC2490484A | example 136 [WO2014183850] | WLN: T C66 K66 A BN JN&T&TJ F1 N1 | GN429E725A | NSC802822 | NSC-802...
  2. PIK-75
    CAS: 372196-77-5 PubChem CID: 45265864 Formula: C16H14BrN5O4S·HCl Molecular Weight: 488.74
    2mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: P423673
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    IUPAC Name
    N-[(E)-(6-bromoimidazo[1,2-a]pyridin-3-yl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamide;hydrochloride
    SMILES
    CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)N=CC2=CN=C3N2C=C(C=C3)Br.Cl
    InChIKey
    VOUDEIAYNKZQKM-MYHMWQFYSA-N
    InChI
    1S/C16H14BrN5O4S.ClH/c1-11-3-5-13(22(23)24)7-15(11)27(25,26)20(2)19-9-14-8-18-16-6-4-12(17)10-21(14)16;/h3-10H,1-2H3;1H/b19-9+;
    Synonyms
    (E)-N'-((6-bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide hydrochloride | (E)...
  3. SF2523
    CAS: 1174428-47-7 PubChem CID: 44180156 Formula: C19H17NO5S Molecular Weight: 371.41
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: S420782
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    IUPAC Name
    3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-morpholin-4-ylthieno[3,2-b]pyran-7-one
    SMILES
    C1COCCN1C2=CC(=O)C3=C(O2)C(=CS3)C4=CC5=C(C=C4)OCCO5
    InChIKey
    BYTKNUOMWLJVNQ-UHFFFAOYSA-N
    InChI
    1S/C19H17NO5S/c21-14-10-17(20-3-5-22-6-4-20)25-18-13(11-26-19(14)18)12-1-2-15-16(9-12)24-8-7-23-15/h1-2,9-11H,3-8H2
    Synonyms
    7H-​Thieno[3,​2-​b]​pyran-​7-​one,3-​(2,​3-​dihydro-​1,​4-​benzodioxin-​6-​yl)​-​5-​(4-​morpholinyl)​-
  4. SF2523
    CAS: 1174428-47-7 PubChem CID: 44180156 Formula: C19H17NO5S Molecular Weight: 371.41
    ● In Stock — US warehouse, ships to EU* Item #: S414074
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    IUPAC Name
    3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-morpholin-4-ylthieno[3,2-b]pyran-7-one
    SMILES
    C1COCCN1C2=CC(=O)C3=C(O2)C(=CS3)C4=CC5=C(C=C4)OCCO5
    InChIKey
    BYTKNUOMWLJVNQ-UHFFFAOYSA-N
    InChI
    1S/C19H17NO5S/c21-14-10-17(20-3-5-22-6-4-20)25-18-13(11-26-19(14)18)12-1-2-15-16(9-12)24-8-7-23-15/h1-2,9-11H,3-8H2
    Synonyms
    7H-​Thieno[3,​2-​b]​pyran-​7-​one,3-​(2,​3-​dihydro-​1,​4-​benzodioxin-​6-​yl)​-​5-​(4-​morpholinyl)​-
  5. Samotolisib (LY3023414), PI3-kinase class I inhibitor
    CAS: 1386874-06-1 PubChem CID: 57519748 Formula: C23H26N4O3 Molecular Weight: 406.48
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: S421463
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    IUPAC Name
    8-[5-(2-hydroxypropan-2-yl)pyridin-3-yl]-1-[(2S)-2-methoxypropyl]-3-methylimidazo[4,5-c]quinolin-2-one
    SMILES
    CC(CN1C2=C3C=C(C=CC3=NC=C2N(C1=O)C)C4=CC(=CN=C4)C(C)(C)O)OC
    InChIKey
    ACCFLVVUVBJNGT-AWEZNQCLSA-N
    InChI
    1S/C23H26N4O3/c1-14(30-5)13-27-21-18-9-15(16-8-17(11-24-10-16)23(2,3)29)6-7-19(18)25-12-20(21)26(4)22(27)28/h6-12,14,29H,13H2,1-5H3/t14-/m0/s1
    Synonyms
    (S)-8-(5-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-(2-methoxypropyl)-3-methyl-1H-imidazo[4,5-c]quinolin-2(3H)-one | ACCFL...
  6. Samotolisib (LY3023414), PI3-kinase class I inhibitor
    CAS: 1386874-06-1 PubChem CID: 57519748 Formula: C23H26N4O3 Molecular Weight: 406.48
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: S413971
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    Technical Identifiers
    IUPAC Name
    8-[5-(2-hydroxypropan-2-yl)pyridin-3-yl]-1-[(2S)-2-methoxypropyl]-3-methylimidazo[4,5-c]quinolin-2-one
    SMILES
    CC(CN1C2=C3C=C(C=CC3=NC=C2N(C1=O)C)C4=CC(=CN=C4)C(C)(C)O)OC
    InChIKey
    ACCFLVVUVBJNGT-AWEZNQCLSA-N
    InChI
    1S/C23H26N4O3/c1-14(30-5)13-27-21-18-9-15(16-8-17(11-24-10-16)23(2,3)29)6-7-19(18)25-12-20(21)26(4)22(27)28/h6-12,14,29H,13H2,1-5H3/t14-/m0/s1
    Synonyms
    (S)-8-(5-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-(2-methoxypropyl)-3-methyl-1H-imidazo[4,5-c]quinolin-2(3H)-one | ACCFL...
  7. YU238259
    CAS: 1943733-16-1 PubChem CID: 121473004 Formula: C22H22ClN3O4S Molecular Weight: 459.95
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: Y422374
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    IUPAC Name
    N-[2-(5-chloropyridin-2-yl)ethyl]-4-[[(4-methoxyphenyl)sulfonylamino]methyl]benzamide
    SMILES
    COC1=CC=C(C=C1)S(=O)(=O)NCC2=CC=C(C=C2)C(=O)NCCC3=NC=C(C=C3)Cl
    InChIKey
    BIHURSOREGLQBB-UHFFFAOYSA-N
    InChI
    1S/C22H22ClN3O4S/c1-30-20-8-10-21(11-9-20)31(28,29)26-14-16-2-4-17(5-3-16)22(27)24-13-12-19-7-6-18(23)15-25-19/h2-11,15,26H,12-14H2,1H3,(H,24,27)
    Synonyms
    Benzamide,N-​[2-​(5-​chloro-​2-​pyridinyl)​ethyl]​-​4-​[[[(4-​methoxyphenyl)​sulfonyl]​amino]​methyl]​-
  8. YU238259
    CAS: 1943733-16-1 PubChem CID: 121473004 Formula: C22H22ClN3O4S Molecular Weight: 459.95
    ● In Stock — US warehouse, ships to EU* Item #: Y413992
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    Technical Identifiers
    IUPAC Name
    N-[2-(5-chloropyridin-2-yl)ethyl]-4-[[(4-methoxyphenyl)sulfonylamino]methyl]benzamide
    SMILES
    COC1=CC=C(C=C1)S(=O)(=O)NCC2=CC=C(C=C2)C(=O)NCCC3=NC=C(C=C3)Cl
    InChIKey
    BIHURSOREGLQBB-UHFFFAOYSA-N
    InChI
    1S/C22H22ClN3O4S/c1-30-20-8-10-21(11-9-20)31(28,29)26-14-16-2-4-17(5-3-16)22(27)24-13-12-19-7-6-18(23)15-25-19/h2-11,15,26H,12-14H2,1H3,(H,24,27)
    Synonyms
    Benzamide,N-​[2-​(5-​chloro-​2-​pyridinyl)​ethyl]​-​4-​[[[(4-​methoxyphenyl)​sulfonyl]​amino]​methyl]​-
  9. STL127705
    CAS: 1326852-06-5 PubChem CID: 53333307 Formula: C22H20FN5O4 Molecular Weight: 437.42
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Made to order · 8–12 wks Item #: S646275
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    IUPAC Name
    2-[2-(3,4-dimethoxyphenyl)ethylamino]-6-(3-fluorophenyl)-8H-pyrimido[4,5-d]pyrimidine-5,7-dione
    SMILES
    COC1=C(C=C(C=C1)CCNC2=NC=C3C(=N2)NC(=O)N(C3=O)C4=CC(=CC=C4)F)OC
    InChIKey
    FPVFCXYTLUJPQJ-UHFFFAOYSA-N
    InChI
    1S/C22H20FN5O4/c1-31-17-7-6-13(10-18(17)32-2)8-9-24-21-25-12-16-19(26-21)27-22(30)28(20(16)29)15-5-3-4-14(23)11-15/h3-7,10-12H,8-9H2,1-2H3,(H2,24,25,2show more
  10. (R)-VX-984
    CAS: 2448475-19-0 Formula: C23H21D2N7O Molecular Weight: 415.49
    ◐ .Made to order · 8–12 wks Item #: V651964
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    Technical Identifiers
    SMILES
    O=C(C1=CC=NC2=C([C@@H](C)CNC3=CC(C4=C([2H])N=C(C)N=C4[2H])=NC=N3)C=CC=C12)NC
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Frequently Asked Questions

What can I find under DNA-PK?
This listing collects compounds associated with DNA-PK within our Cell Cycle/DNA Damage area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.
What should I consider when picking a compound for DNA-PK?
Consider the reported potency of each DNA-PK compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.
What quality information is provided for DNA-PK compounds?
Each DNA-PK product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search DNA-PK compounds by activity or structure?
Yes. Filter the DNA-PK listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].

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