EGFR
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852 products
Popular Products
- Afatinib dimaleate, Receptor protein-tyrosine kinase erbB-4 inhibitorCAS: 850140-73-7 EC Number: 810-416-1 PubChem CID: 15606394 Formula: C32H33ClFN5O11 Molecular Weight: 718.08● In Stock — US warehouse, ships to EU* Item #: A288214View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (Z)-but-2-enedioic acid;(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
- SMILES
- CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O
- InChIKey
- USNRYVNRPYXCSP-JUGPPOIOSA-N
- InChI
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- Synonyms
- BIBW2992 DiMaleate | (2E)-N-(4-[(3-chloro-4-fluorophenyl)amino]-7-{[(3S)-tetrahydrofuran-3-yl]oxy}quinazolin-6-yl)-4-...
- Varlitinib, Receptor protein-tyrosine kinase erbB-2 inhibitorCAS: 845272-21-1 EC Number: 807-347-4 PubChem CID: 42642648 Formula: C22H19ClN6O2S Molecular Weight: 466.94Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥96%● In Stock — US warehouse, ships to EU* Item #: V129433View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 4-N-[3-chloro-4-(1,3-thiazol-2-ylmethoxy)phenyl]-6-N-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]quinazoline-4,6-diamine
- SMILES
- CC1COC(=N1)NC2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=NC=CS5)Cl
- InChIKey
- UWXSAYUXVSFDBQ-CYBMUJFWSA-N
- InChI
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- Synonyms
- 4,6-Quinazolinediamine, N(sup 4)-(3-chloro-4-(2-thiazolylmethoxy)phenyl)-N(sup 6)-((4R)-4,5- dihydro-4-methyl-2-oxazo...
- Methyl 2，5-DihydroxycinnamateCAS: 63177-57-1 Formula: C10H10O4 Molecular Weight: 194.18● In Stock — US warehouse, ships to EU* Item #: M136980View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- methyl (E)-3-(2,5-dihydroxyphenyl)prop-2-enoate
- SMILES
- COC(=O)C=CC1=C(C=CC(=C1)O)O
- InChIKey
- BQCNSTFWSKOWMA-GORDUTHDSA-N
- InChI
- 1S/C10H10O4/c1-14-10(13)5-2-7-6-8(11)3-4-9(7)12/h2-6,11-12H,1H3/b5-2+
- Synonyms
- K00021 | BMK1-G1 | BS-14687 | 3-(2,5-Dihydroxy-phenyl)-acrylic acid methyl ester | 2,4-Dihydroxymethylcinnamate | Met...
- Tyrphostin AG 494CAS: 133550-35-3 EC Number: 810-936-9 PubChem CID: 5328771 Formula: C16H12N2O3 Molecular Weight: 280.28● In Stock — US warehouse, ships to EU* Item #: T162509View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-2-enamide
- SMILES
- C1=CC=C(C=C1)NC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N
- InChIKey
- HKHOVJYOELRGMV-XYOKQWHBSA-N
- InChI
- 1S/C16H12N2O3/c17-10-12(8-11-6-7-14(19)15(20)9-11)16(21)18-13-4-2-1-3-5-13/h1-9,19-20H,(H,18,21)/b12-8+
- Synonyms
- MKXZASYAUGDDCJ-UHFFFAOYSA-N | DTXSID201018515 | HMS3414I07 | s6509 | AKOS024458583 | HMS2232N04 | NCGC00024687-02 | B...
- AG 1478 hydrochlorideCAS: 170449-18-0 Formula: C16H15Cl2N3O2 Molecular Weight: 352.22● In Stock — US warehouse, ships to EU* Item #: A287390View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine;hydrochloride
- SMILES
- COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC.Cl
- InChIKey
- WDJDYIUSDDVWKB-UHFFFAOYSA-N
- InChI
- 1S/C16H14ClN3O2.ClH/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11;/h3-9H,1-2H3,(H,18,19,20);1H
- Synonyms
- AG 1478 HYDROCHLORIDE | AG-1478.hcl | 4-Quinazolinamine, N-(3-chlorophenyl)-6,7-dimethoxy-, monohydrochloride | DS-13...
- Daphnetin● In Stock — US warehouse, ships to EU* Item #: D155111View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 7,8-dihydroxychromen-2-one
- SMILES
- C1=CC(=C(C2=C1C=CC(=O)O2)O)O
- InChIKey
- ATEFPOUAMCWAQS-UHFFFAOYSA-N
- InChI
- 1S/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H
- Synonyms
- Spectrum4_001254 | 7,8-Dihydroxy-2H-1-benzopyran-2-one | XC84571RD2 | KBio1_001904 | ATEFPOUAMCWAQS-UHFFFAOYSA-N | BD...
- Tyrphostin B44, (+) enantiomerCAS: 133550-37-5 EC Number: 835-467-7 PubChem CID: 5328769 Formula: C18H16N2O3 Molecular Weight: 308.34Solid ≥98%● In Stock — US warehouse, ships to EU* Item #: T288351View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]prop-2-enamide
- SMILES
- CC(C1=CC=CC=C1)NC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N
- InChIKey
- UMGQVUWXNOJOSJ-DGGAMASNSA-N
- InChI
- 1S/C18H16N2O3/c1-12(14-5-3-2-4-6-14)20-18(23)15(11-19)9-13-7-8-16(21)17(22)10-13/h2-10,12,21-22H,1H3,(H,20,23)/b15-9+/t12-/m0/s1
- Synonyms
- Lopac-T-4443 | Lopac-T-5568 | Tox21_501198 | (2E)-2-Cyano-3-(3,4-Dihydroxyphenyl)-N-[(1S)-1-Phenylethyl]-2-Propenamid...
- AST-1306, Inhibitor of epidermal growth factor receptor;Inhibitor of erb-b2 receptor tyrosine kinase 2;Inhibitor of erb-b2 receptor tyrosine kinase 4CAS: 897383-62-9 Formula: C24H18ClFN4O2 Molecular Weight: 448.88Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: A127889View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]prop-2-enamide
- SMILES
- C=CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=C(C=C3)OCC4=CC(=CC=C4)F)Cl
- InChIKey
- MVZGYPSXNDCANY-UHFFFAOYSA-N
- InChI
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- Synonyms
- ALL-3 | MANDELIC-2,3,4,5,6-D5 ACID | SB19364 | SR-01000076076-1 | XKB38362 | 4-hydroxy-3-methoxyphenylglycolic acid |...
- AV 412CAS: 451492-95-8 Formula: C27H28ClFN6O Molecular Weight: 507Solid ≥98%(HPLC)● In Stock — US warehouse, ships to EU* Item #: A288169View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[4-(3-chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide
- SMILES
- CC(C)(C#CC1=CC2=C(C=C1NC(=O)C=C)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)N4CCN(CC4)C
- InChIKey
- ZAJXXUDARPGGOC-UHFFFAOYSA-N
- InChI
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- Synonyms
- MLS001204877 | NCGC00263195-04 | HMS3244M16 | SMR001224381 | 2-Propenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-(...
- AZD-9291 mesylate, Epidermal growth factor receptor erbB1 inhibitor● In Stock — US warehouse, ships to EU* Item #: A302850View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide;methanesulfonic acid
- SMILES
- CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC.CS(=O)(=O)O
- InChIKey
- FUKSNUHSJBTCFJ-UHFFFAOYSA-N
- InChI
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- Synonyms
- N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-pro...
- Osimertinib (AZD9291), Epidermal growth factor receptor erbB1 inhibitorMoligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%● In Stock — US warehouse, ships to EU* Item #: A302849View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide
- SMILES
- CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC
- InChIKey
- DUYJMQONPNNFPI-UHFFFAOYSA-N
- InChI
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- Synonyms
- Mereletinib | AZD-9291
- AG 555 (Tyrphostin B46)CAS: 133550-34-2 Formula: C19H18N2O3 Molecular Weight: 322.36● In Stock — US warehouse, ships to EU* Item #: A275199View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)prop-2-enamide
- SMILES
- C1=CC=C(C=C1)CCCNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N
- InChIKey
- GSQOBTOAOGXIFL-LFIBNONCSA-N
- InChI
- 1S/C19H18N2O3/c20-13-16(11-15-8-9-17(22)18(23)12-15)19(24)21-10-4-7-14-5-2-1-3-6-14/h1-3,5-6,8-9,11-12,22-23H,4,7,10H2,(H,21,24)/b16-11+
- Synonyms
- NCGC00016028-05 | Tyrphostin deriv. 46 | J-006402 | 2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)-...
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Frequently Asked Questions
How is the EGFR listing put together?
It draws on reported EGFR annotations within JAK/STAT Signaling and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose an EGFR modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the EGFR entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for EGFR compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For EGFR work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the EGFR compound I need is not listed?
Search by CAS number or SMILES first, since analogs of EGFR compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.