GlyT

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  1. ASP 2535, Inhibitor of GlyT1
    CAS: 374886-51-8 Formula: C22H18N6O Molecular Weight: 382.42
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95%
    ◐ .Made to order · 8–12 wks Item #: A275113
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    IUPAC Name
    4-[3-(6-phenylpyridin-3-yl)-5-propan-2-yl-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole
    SMILES
    CC(C)C1=NN=C(N1C2=CC=CC3=NON=C32)C4=CN=C(C=C4)C5=CC=CC=C5
    InChIKey
    FQGLDGKVKDPVLO-UHFFFAOYSA-N
    InChI
    1S/C22H18N6O/c1-14(2)21-24-25-22(28(21)19-10-6-9-18-20(19)27-29-26-18)16-11-12-17(23-13-16)15-7-4-3-5-8-15/h3-14H,1-2H3
    Synonyms
    4-[3-(1-Methylethyl)-5-(6-phenyl-3-pyridinyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole
  2. NFPS, GlyT1
    CAS: 405225-21-0 Formula: C24H24FNO3 Molecular Weight: 393.45
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ◐ .Made to order · 8–12 wks Item #: N288067
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    IUPAC Name
    2-[[3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic acid
    SMILES
    CN(CCC(C1=CC=C(C=C1)F)OC2=CC=C(C=C2)C3=CC=CC=C3)CC(=O)O
    InChIKey
    FDORQEIHOKEJNX-UHFFFAOYSA-N
    InChI
    1S/C24H24FNO3/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18/h2-14,23H,15-17H2,1H3,(H,27,28)
    Synonyms
    ALX5407 | GTPL4620 | DTXSID30415522 | GTPL4619 | N-[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine | 2-{[3-...
  3. Sarcosine
    CAS: 107-97-1 EC Number: 203-538-6 PubChem CID: 1088 Formula: C3H7NO2 Molecular Weight: 89.09
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — Germany Item #: S102891
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    IUPAC Name
    2-(methylamino)acetic acid
    SMILES
    CNCC(=O)O
    InChIKey
    FSYKKLYZXJSNPZ-UHFFFAOYSA-N
    InChI
    1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6)
    Synonyms
    GTPL4713 | N-Cocoyl sarcosine | (Methylamino)ethanoic acid | Me-Gly-OH | (methylamino)acetate | (methylamino)-Acetate...
  4. Org 24598, Inhibitor of GlyT1
    CAS: 372198-97-5 Formula: C19H20F3NO3 Molecular Weight: 367.36
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: O287216
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    IUPAC Name
    2-[methyl-[(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]amino]acetic acid
    SMILES
    CN(CCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F)CC(=O)O
    InChIKey
    KZWQAWBTWNPFPW-QGZVFWFLSA-N
    InChI
    1S/C19H20F3NO3/c1-23(13-18(24)25)12-11-17(14-5-3-2-4-6-14)26-16-9-7-15(8-10-16)19(20,21)22/h2-10,17H,11-13H2,1H3,(H,24,25)/t17-/m1/s1
    Synonyms
    N-Methyl-N-[(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]-glycine
  5. Org 25543 hydrochloride
    CAS: 495076-64-7 Formula: C₂₄H₃₂lN₂O₄.HCl Molecular Weight: 448.98
    ◐ .Made to order · 8–12 wks Item #: O287212
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    IUPAC Name
    N-[[1-(dimethylamino)cyclopentyl]methyl]-3,5-dimethoxy-4-phenylmethoxybenzamide;hydrochloride
    SMILES
    CN(C)C1(CCCC1)CNC(=O)C2=CC(=C(C(=C2)OC)OCC3=CC=CC=C3)OC.Cl
    InChIKey
    NIPQJILJYQVZJR-UHFFFAOYSA-N
    InChI
    1S/C24H32N2O4.ClH/c1-26(2)24(12-8-9-13-24)17-25-23(27)19-14-20(28-3)22(21(15-19)29-4)30-16-18-10-6-5-7-11-18;/h5-7,10-11,14-15H,8-9,12-13,16-17H2,1-4Hshow more
    Synonyms
    N-[[1-(Dimethylamino)cyclopentyl]methyl]-3,5-dimethoxy-4-(phenylmethoxy)benzamide hydrochloride
  6. LY 2365109 hydrochloride
    CAS: 1779796-27-8 PubChem CID: 56972229 Formula: C22H28ClNO5 Molecular Weight: 421.9
    ● In Stock — US warehouse, ships to EU* Item #: L286604
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    IUPAC Name
    2-[2-[4-(1,3-benzodioxol-5-yl)-2-tert-butylphenoxy]ethyl-methylamino]acetic acid;hydrochloride
    SMILES
    CC(C)(C)C1=C(C=CC(=C1)C2=CC3=C(C=C2)OCO3)OCCN(C)CC(=O)O.Cl
    InChIKey
    ZQVOAGQZHDAFRM-UHFFFAOYSA-N
    InChI
    1S/C22H27NO5.ClH/c1-22(2,3)17-11-15(16-6-8-19-20(12-16)28-14-27-19)5-7-18(17)26-10-9-23(4)13-21(24)25;/h5-8,11-12H,9-10,13-14H2,1-4H3,(H,24,25);1H
    Synonyms
    N-[2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycine hydrochloride
  7. Bitopertin, Glycine transporter 1 inhibitor
    CAS: 845614-11-1 Formula: C21H20F7N3O4S Molecular Weight: 543.46
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: B127005
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    Technical Identifiers
    IUPAC Name
    [4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]-[5-methylsulfonyl-2-[(2S)-1,1,1-trifluoropropan-2-yl]oxyphenyl]methanone
    SMILES
    CC(C(F)(F)F)OC1=C(C=C(C=C1)S(=O)(=O)C)C(=O)N2CCN(CC2)C3=C(C=C(C=N3)C(F)(F)F)F
    InChIKey
    YUUGYIUSCYNSQR-LBPRGKRZSA-N
    InChI
    1S/C21H20F7N3O4S/c1-12(20(23,24)25)35-17-4-3-14(36(2,33)34)10-15(17)19(32)31-7-5-30(6-8-31)18-16(22)9-13(11-29-18)21(26,27)28/h3-4,9-12H,5-8H2,1-2H3/tshow more
    Synonyms
    RG1678 | RO4917838 | DISC-1459 | 2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone | MFCD18251496 | METHANONE, (4-(3-FL...
  8. oleoyl L-carnitine
    CAS: 13962-05-5 Formula: C25H47NO4 Molecular Weight: 425.64
    ◐ .Made to order · 8–12 wks Item #: O130781
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    IUPAC Name
    3-[(Z)-octadec-9-enoyl]oxy-4-(trimethylazaniumyl)butanoate
    SMILES
    CCCCCCCCC=CCCCCCCCC(=O)OC(CC(=O)[O-])C[N+](C)(C)C
    InChIKey
    IPOLTUVFXFHAHI-SEYXRHQNSA-N
    InChI
    1S/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12-
    Synonyms
    Oleoylcarnitine|O-oleoylcarnitine|13962-05-5|acylcarnitine C18:1|(9Z)-octadec-9-enoylcarnitine|3-[(Z)-octadec-9-enoyl...
  9. ALX 5407 hydrochloride
    CAS: 200006-08-2 PubChem CID: 16078946 Formula: C24H24FNO3•HCl Molecular Weight: 429.92
    ◐ .Made to order · 8–12 wks Item #: A286994
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    Technical Identifiers
    IUPAC Name
    2-[[(3R)-3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic acid;hydrochloride
    SMILES
    CN(CCC(C1=CC=C(C=C1)F)OC2=CC=C(C=C2)C3=CC=CC=C3)CC(=O)O.Cl
    InChIKey
    RPDGSZCYSJWQEE-GNAFDRTKSA-N
    InChI
    1S/C24H24FNO3.ClH/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18;/h2-14,23H,15-17H2,1H3,(H,27,28);1H/t23-;/m1show more
    Synonyms
    2-[[(3R)-3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic acid;hydrochloride | DTXSID60582019 | J-012...
  10. Bitopertin, Glycine transporter 1 inhibitor
    CAS: 845614-11-1 Formula: C21H20F7N3O4S Molecular Weight: 543.46
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: B426201
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    Technical Identifiers
    IUPAC Name
    [4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]-[5-methylsulfonyl-2-[(2S)-1,1,1-trifluoropropan-2-yl]oxyphenyl]methanone
    SMILES
    CC(C(F)(F)F)OC1=C(C=C(C=C1)S(=O)(=O)C)C(=O)N2CCN(CC2)C3=C(C=C(C=N3)C(F)(F)F)F
    InChIKey
    YUUGYIUSCYNSQR-LBPRGKRZSA-N
    InChI
    1S/C21H20F7N3O4S/c1-12(20(23,24)25)35-17-4-3-14(36(2,33)34)10-15(17)19(32)31-7-5-30(6-8-31)18-16(22)9-13(11-29-18)21(26,27)28/h3-4,9-12H,5-8H2,1-2H3/tshow more
    Synonyms
    RG1678 | RO4917838 | DISC-1459 | 2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone | MFCD18251496 | METHANONE, (4-(3-FL...
  11. MPDC
    CAS: 159262-32-5 PubChem CID: 6604785 Formula: C7H9NO4 Molecular Weight: 171.15
    ◐ .Made to order · 8–12 wks Item #: M287564
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    IUPAC Name
    (1R,2S,5S,6S)-3-azabicyclo[3.1.0]hexane-2,6-dicarboxylic acid
    SMILES
    C1C2C(C2C(=O)O)C(N1)C(=O)O
    InChIKey
    UNNFLFDQCHJXPI-QTBDOELSSA-N
    InChI
    1S/C7H9NO4/c9-6(10)4-2-1-8-5(3(2)4)7(11)12/h2-5,8H,1H2,(H,9,10)(H,11,12)/t2-,3+,4-,5-/m0/s1
    Synonyms
    L-anti-endo-3,4-Methanopyrrolidinedicarboxylic acid
  12. N-Arachidonylglycine (NAGly), Agonist of GPR18;Agonist of LPA 5 receptor
    CAS: 179113-91-8 Formula: C22H35NO3 Molecular Weight: 361.52
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: A275341
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    Technical Identifiers
    IUPAC Name
    2-[[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]amino]acetic acid
    SMILES
    CCCCCC=CCC=CCC=CCC=CCCCC(=O)NCC(=O)O
    InChIKey
    YLEARPUNMCCKMP-DOFZRALJSA-N
    InChI
    1S/C22H35NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21(24)23-20-22(25)26/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-20H2,1H3,(H,23,24)(H,25,26)/bshow more
    Synonyms
    LP00074 | NAGly | NA-Gly | HMS1989I06 | N-((5Z,8Z,11Z,14Z)-1-Oxo-5,8,11,14-eicosatetraen-1-yl)glycine | N-arachidonoy...
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Frequently Asked Questions

How is the GlyT listing put together?
It draws on reported GlyT annotations within Membrane Transporter/Ion Channel and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose a GlyT modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the GlyT entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for GlyT compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For GlyT work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the GlyT compound I need is not listed?
Search by CAS number or SMILES first, since analogs of GlyT compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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