GPR119

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  1. PSN 375963 hydrochloride, Agonist of GPR119
    CAS: 388575-52-8 PubChem CID: 2875918 Formula: C17H23N3O Molecular Weight: 285.38
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Made to order · 8–12 wks Item #: P347546
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    IUPAC Name
    5-(4-butylcyclohexyl)-3-pyridin-4-yl-1,2,4-oxadiazole
    SMILES
    CCCCC1CCC(CC1)C2=NC(=NO2)C3=CC=NC=C3
    InChIKey
    OAVLEYPTWABFLF-UHFFFAOYSA-N
    InChI
    1S/C17H23N3O/c1-2-3-4-13-5-7-15(8-6-13)17-19-16(20-21-17)14-9-11-18-12-10-14/h9-13,15H,2-8H2,1H3
  2. AR 231453, Agonist of GPR119
    CAS: 733750-99-7 Formula: C21H24FN7O5S Molecular Weight: 505.53
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ◐ .Made to order · 8–12 wks Item #: A275017
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    IUPAC Name
    N-(2-fluoro-4-methylsulfonylphenyl)-5-nitro-6-[4-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]pyrimidin-4-amine
    SMILES
    CC(C)C1=NOC(=N1)C2CCN(CC2)C3=NC=NC(=C3[N+](=O)[O-])NC4=C(C=C(C=C4)S(=O)(=O)C)F
    InChIKey
    DGBKNTVAKIFYNU-UHFFFAOYSA-N
    InChI
    1S/C21H24FN7O5S/c1-12(2)18-26-21(34-27-18)13-6-8-28(9-7-13)20-17(29(30)31)19(23-11-24-20)25-16-5-4-14(10-15(16)22)35(3,32)33/h4-5,10-13H,6-9H2,1-3H3,(show more
    Synonyms
    SPBio_002876 | N-(2-fluoro-4-methanesulfonylphenyl)-(6-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-5-nitro...
  3. AS 1269574, Agonist of GPR119
    CAS: 330981-72-1 Formula: C13H14BrN3O Molecular Weight: 308.17
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: A288879
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    IUPAC Name
    2-[[2-(4-bromophenyl)-6-methylpyrimidin-4-yl]amino]ethanol
    SMILES
    CC1=CC(=NC(=N1)C2=CC=C(C=C2)Br)NCCO
    InChIKey
    DUKPGOOUJNUIOI-UHFFFAOYSA-N
    InChI
    1S/C13H14BrN3O/c1-9-8-12(15-6-7-18)17-13(16-9)10-2-4-11(14)5-3-10/h2-5,8,18H,6-7H2,1H3,(H,15,16,17)
    Synonyms
    HY-107535 | 2-(2-(4-bromophenyl)-6-methylpyrimidin-4-ylamino)ethanol | DTXSID90416373 | 2-[[2-(4-Bromophenyl)-6-methy...
  4. MBX-2982, Glucose-dependent insulinotropic receptor agonist
    CAS: 1037792-44-1 Formula: C22H24N8OS Molecular Weight: 448.54
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: M127623
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    IUPAC Name
    2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole
    SMILES
    CCC1=CN=C(N=C1)N2CCC(CC2)C3=NC(=CS3)COC4=CC=C(C=C4)N5C=NN=N5
    InChIKey
    NFTMKHWBOINJGM-UHFFFAOYSA-N
    InChI
    1S/C22H24N8OS/c1-2-16-11-23-22(24-12-16)29-9-7-17(8-10-29)21-26-18(14-32-21)13-31-20-5-3-19(4-6-20)30-15-25-27-28-30/h3-6,11-12,14-15,17H,2,7-10,13H2,show more
    Synonyms
    MBX 2982 | EX-A1003 | MBX2982 | MBX-2982 | DTXSID20146055 | AMY39989 | BDBM50013909 | MFCD22628771 | 8VP | 2-[1-(5-et...
  5. APD597, Agonist of GPR119
    CAS: 897732-93-3 Formula: C21H29N5O6S Molecular Weight: 479.55
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: A426734
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    IUPAC Name
    propan-2-yl 4-[5-methoxy-6-[(2-methyl-6-methylsulfonylpyridin-3-yl)amino]pyrimidin-4-yl]oxypiperidine-1-carboxylate
    SMILES
    CC1=C(C=CC(=N1)S(=O)(=O)C)NC2=C(C(=NC=N2)OC3CCN(CC3)C(=O)OC(C)C)OC
    InChIKey
    WPDCHTSXOPUOII-UHFFFAOYSA-N
    InChI
    1S/C21H29N5O6S/c1-13(2)31-21(27)26-10-8-15(9-11-26)32-20-18(30-4)19(22-12-23-20)25-16-6-7-17(24-14(16)3)33(5,28)29/h6-7,12-13,15H,8-11H2,1-5H3,(H,22,2show more
    Synonyms
    3-Hydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxalin-2-ol anion | DB12084 | 4-[6-(6-methanesulfonyl-2-methyl-pyridin-3-yl...
  6. APD597, Agonist of GPR119
    CAS: 897732-93-3 Formula: C21H29N5O6S Molecular Weight: 479.55
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: A412183
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    IUPAC Name
    propan-2-yl 4-[5-methoxy-6-[(2-methyl-6-methylsulfonylpyridin-3-yl)amino]pyrimidin-4-yl]oxypiperidine-1-carboxylate
    SMILES
    CC1=C(C=CC(=N1)S(=O)(=O)C)NC2=C(C(=NC=N2)OC3CCN(CC3)C(=O)OC(C)C)OC
    InChIKey
    WPDCHTSXOPUOII-UHFFFAOYSA-N
    InChI
    1S/C21H29N5O6S/c1-13(2)31-21(27)26-10-8-15(9-11-26)32-20-18(30-4)19(22-12-23-20)25-16-6-7-17(24-14(16)3)33(5,28)29/h6-7,12-13,15H,8-11H2,1-5H3,(H,22,2show more
    Synonyms
    3-Hydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxalin-2-ol anion | DB12084 | 4-[6-(6-methanesulfonyl-2-methyl-pyridin-3-yl...
  7. APD668, Agonist of GPR119
    CAS: 832714-46-2 Formula: C21H24FN5O5S Molecular Weight: 477.51
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥96%
    ● In Stock — US warehouse, ships to EU* Item #: A413612
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    IUPAC Name
    propan-2-yl 4-[1-(2-fluoro-4-methylsulfonylphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxypiperidine-1-carboxylate
    SMILES
    CC(C)OC(=O)N1CCC(CC1)OC2=NC=NC3=C2C=NN3C4=C(C=C(C=C4)S(=O)(=O)C)F
    InChIKey
    XTRUQJBVQBUKSQ-UHFFFAOYSA-N
    InChI
    1S/C21H24FN5O5S/c1-13(2)31-21(28)26-8-6-14(7-9-26)32-20-16-11-25-27(19(16)23-12-24-20)18-5-4-15(10-17(18)22)33(3,29)30/h4-5,10-14H,6-9H2,1-3H3
    Synonyms
    BCP10207 | HY-Y1031A | ISOPROPYL 4-{[1-(2-FLUORO-4-METHANESULFONYLPHENYL)PYRAZOLO[3,4-D]PYRIMIDIN-4-YL]OXY}PIPERIDINE...
  8. APD668, Agonist of GPR119
    CAS: 832714-46-2 Formula: C21H24FN5O5S Molecular Weight: 477.51
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: A426154
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    Technical Identifiers
    IUPAC Name
    propan-2-yl 4-[1-(2-fluoro-4-methylsulfonylphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxypiperidine-1-carboxylate
    SMILES
    CC(C)OC(=O)N1CCC(CC1)OC2=NC=NC3=C2C=NN3C4=C(C=C(C=C4)S(=O)(=O)C)F
    InChIKey
    XTRUQJBVQBUKSQ-UHFFFAOYSA-N
    InChI
    1S/C21H24FN5O5S/c1-13(2)31-21(28)26-8-6-14(7-9-26)32-20-16-11-25-27(19(16)23-12-24-20)18-5-4-15(10-17(18)22)33(3,29)30/h4-5,10-14H,6-9H2,1-3H3
    Synonyms
    BCP10207 | HY-Y1031A | ISOPROPYL 4-{[1-(2-FLUORO-4-METHANESULFONYLPHENYL)PYRAZOLO[3,4-D]PYRIMIDIN-4-YL]OXY}PIPERIDINE...
  9. GSK1292263, Glucose-dependent insulinotropic receptor agonist
    CAS: 1032823-75-8 Formula: C23H28N4O4S Molecular Weight: 456.56
    ● In Stock — US warehouse, ships to EU* Item #: G127614
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    Technical Identifiers
    IUPAC Name
    5-[4-[[6-(4-methylsulfonylphenyl)pyridin-3-yl]oxymethyl]piperidin-1-yl]-3-propan-2-yl-1,2,4-oxadiazole
    SMILES
    CC(C)C1=NOC(=N1)N2CCC(CC2)COC3=CN=C(C=C3)C4=CC=C(C=C4)S(=O)(=O)C
    InChIKey
    AYJRTVVIBJSSKN-UHFFFAOYSA-N
    InChI
    1S/C23H28N4O4S/c1-16(2)22-25-23(31-26-22)27-12-10-17(11-13-27)15-30-19-6-9-21(24-14-19)18-4-7-20(8-5-18)32(3,28)29/h4-9,14,16-17H,10-13,15H2,1-3H3
    Synonyms
    Pyridine, 5-((1-(3-(1-methylethyl)-1,2,4-oxadiazol-5-yl)-4-piperidinyl)methoxy)-2-(4-(methylsulfonyl)phenyl)- | BCP90...
  10. AS1907417, Agonist of GPR119
    CAS: 885038-66-4 PubChem CID: 11567371
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: A607755
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    IUPAC Name
    4-[1-(2-cyclobutyl-6,6-dioxo-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperidin-4-yl]butanoic acid
    SMILES
    OC(=O)CCCC1CCN(CC1)c1nc(nc2c1CS(=O)(=O)C2)C1CCC1
    InChIKey
    NFFANIJTECFGGM-UHFFFAOYSA-N
    InChI
    1S/C19H27N3O4S/c23-17(24)6-1-3-13-7-9-22(10-8-13)19-15-11-27(25,26)12-16(15)20-18(21-19)14-4-2-5-14/h13-14H,1-12H2,(H,23,24)
    Synonyms
    AS 1907417;AS-1907417
  11. DS-8500a, Agonist of GPR119
    CAS: 1371591-51-3 PubChem CID: 56959560
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: D609984
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    IUPAC Name
    4-[5-[(1R)-1-[4-(cyclopropanecarbonyl)phenoxy]propyl]-1,2,4-oxadiazol-3-yl]-2-fluoro-N-[(2R)-1-hydroxypropan-2-yl]benzamide
    SMILES
    CCC(C1=NC(=NO1)C2=CC(=C(C=C2)C(=O)NC(C)CO)F)OC3=CC=C(C=C3)C(=O)C4CC4
    InChIKey
    LRXRIKVDAVVQCP-SPLOXXLWSA-N
    InChI
    1S/C25H26FN3O5/c1-3-21(33-18-9-6-16(7-10-18)22(31)15-4-5-15)25-28-23(29-34-25)17-8-11-19(20(26)12-17)24(32)27-14(2)13-30/h6-12,14-15,21,30H,3-5,13H2,1show more
    Synonyms
    08P99TX229 | 4(5-((1-(S))-1-(4-(cyclopropanecarbonyl)phenoxy)propyl)-1,2,4-oxadiazol-3-yl)-2-fluoro-(N)-((2-(S))-1-hy...
  12. PSN632408, Agonist of GPR119
    CAS: 857652-30-3 Formula: C18H24N4O4 Molecular Weight: 360.41
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Made to order · 8–12 wks Item #: P612998
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    Technical Identifiers
    IUPAC Name
    tert-butyl 4-[(3-pyridin-4-yl-1,2,4-oxadiazol-5-yl)methoxy]piperidine-1-carboxylate
    SMILES
    O=C(N1CCC(CC1)OCc1onc(n1)c1ccncc1)OC(C)(C)C
    InChIKey
    LHZWKWCEAXQUMX-UHFFFAOYSA-N
    InChI
    1S/C18H24N4O4/c1-18(2,3)25-17(23)22-10-6-14(7-11-22)24-12-15-20-16(21-26-15)13-4-8-19-9-5-13/h4-5,8-9,14H,6-7,10-12H2,1-3H3
    Synonyms
    BBL103893 | EN300-18423838 | Tert-butyl 4-[(3-pyridin-4-yl-1,2,4-oxadiazol-5-yl)methoxy]piperidine-1-carboxylate | AK...
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Frequently Asked Questions

Which compounds are listed for GPR119?
Compounds associated with GPR119 are grouped here under the Neuronal Signaling classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.
How does GPR119 sit within Neuronal Signaling?
GPR119 is one target listing within the Neuronal Signaling classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.
What data should I check before ordering a compound from GPR119?
For compounds listed under GPR119, check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
How do I find related targets or backup compounds for GPR119?
Browse the parent Neuronal Signaling listing to reach targets neighbouring GPR119, and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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