GPR139

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  1. JNJ 63533054, Agonist of GPR139
    CAS: 1802326-66-4 EC Number: 110-689-0 Formula: C17H17ClN2O2 Molecular Weight: 316.78
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: J288738
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    Technical Identifiers
    IUPAC Name
    3-chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide
    SMILES
    CC(C1=CC=CC=C1)NC(=O)CNC(=O)C2=CC(=CC=C2)Cl
    InChIKey
    MWDVCHRYCKXEBY-LBPRGKRZSA-N
    InChI
    1S/C17H17ClN2O2/c1-12(13-6-3-2-4-7-13)20-16(21)11-19-17(22)14-8-5-9-15(18)10-14/h2-10,12H,11H2,1H3,(H,19,22)(H,20,21)/t12-/m0/s1
    Synonyms
    3-Chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide | (S)-3-Chloro-N-(2-oxo-2-((1-phenylethyl)amino)ethyl)...
  2. TC-O 9311
    CAS: 444932-31-4 PubChem CID: 3376937 Formula: C200H19N3O4 Molecular Weight: 365.38
    ● In Stock — US warehouse, ships to EU* Item #: T287907
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    IUPAC Name
    1-[(3,5-dimethoxybenzoyl)amino]-3-naphthalen-1-ylurea
    SMILES
    COC1=CC(=CC(=C1)C(=O)NNC(=O)NC2=CC=CC3=CC=CC=C32)OC
    InChIKey
    KPTMSQHTGZMEFU-UHFFFAOYSA-N
    InChI
    1S/C20H19N3O4/c1-26-15-10-14(11-16(12-15)27-2)19(24)22-23-20(25)21-18-9-5-7-13-6-3-4-8-17(13)18/h3-12H,1-2H3,(H,22,24)(H2,21,23,25)
    Synonyms
    Z)-N'-((Z)-hydroxy(naphthalen-1-ylimino)methyl)-3,5-dimethoxybenzohydrazonic acid | 3,5-Dimethoxybenzoic acid 2-[(1-n...
  3. JNJ 63533054, Agonist of GPR139
    CAS: 1802326-66-4 EC Number: 110-689-0 Formula: C17H17ClN2O2 Molecular Weight: 316.78
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: J422208
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    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    3-chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide
    SMILES
    CC(C1=CC=CC=C1)NC(=O)CNC(=O)C2=CC(=CC=C2)Cl
    InChIKey
    MWDVCHRYCKXEBY-LBPRGKRZSA-N
    InChI
    1S/C17H17ClN2O2/c1-12(13-6-3-2-4-7-13)20-16(21)11-19-17(22)14-8-5-9-15(18)10-14/h2-10,12H,11H2,1H3,(H,19,22)(H,20,21)/t12-/m0/s1
    Synonyms
    3-Chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide;(S)-3-Chloro-N-(2-oxo-2-((1-phenylethyl)amino)ethyl)be...
  4. TAK-041, Agonist of GPR139
    CAS: 1929519-13-0 Formula: C18H15F3N4O3 Molecular Weight: 392.33
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: T614307
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    IUPAC Name
    2-(4-oxo-1,2,3-benzotriazin-3-yl)-N-[(1S)-1-[4-(trifluoromethoxy)phenyl]ethyl]acetamide
    SMILES
    CC(C1=CC=C(C=C1)OC(F)(F)F)NC(=O)CN2C(=O)C3=CC=CC=C3N=N2
    InChIKey
    JZGLECLGVQRPPI-NSHDSACASA-N
    InChI
    1S/C18H15F3N4O3/c1-11(12-6-8-13(9-7-12)28-18(19,20)21)22-16(26)10-25-17(27)14-4-2-3-5-15(14)23-24-25/h2-9,11H,10H2,1H3,(H,22,26)/t11-/m0/s1
    Synonyms
    (S)-2-(4-Oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethoxy)phenyl)ethyl)acetamide | Zelatriazin
  5. NCRW0005-F05
    CAS: 342779-66-2 PubChem CID: 5017692 Formula: C16H13F2NO2 Molecular Weight: 289.28
    ◐ .Made to order · 8–12 wks Item #: N648026
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    Technical Identifiers
    IUPAC Name
    3,3-difluoro-4-(4-methoxyphenyl)-1-phenylazetidin-2-one
    SMILES
    COC1=CC=C(C=C1)C2C(C(=O)N2C3=CC=CC=C3)(F)F
    InChIKey
    AIIIYUSGINMZMS-UHFFFAOYSA-N
    InChI
    1S/C16H13F2NO2/c1-21-13-9-7-11(8-10-13)14-16(17,18)15(20)19(14)12-5-3-2-4-6-12/h2-10,14H,1H3
  6. TC-O 9311
    CAS: 444932-31-4 PubChem CID: 3376937 Formula: C200H19N3O4 Molecular Weight: 365.38
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10 mM in DMSO
    ◐ .Made to order · 8–12 wks Item #: T1493453
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    Technical Identifiers
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Frequently Asked Questions

How is the GPR139 listing put together?
It draws on reported GPR139 annotations within GPCR/G Protein and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose a GPR139 modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the GPR139 entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for GPR139 compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For GPR139 work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the GPR139 compound I need is not listed?
Search by CAS number or SMILES first, since analogs of GPR139 compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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