HMG-CoA Reductase (HMGCR)

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  1. Lovastatin Hydroxy Acid, Sodium Salt
    CAS: 75225-50-2 EC Number: 641-623-3 PubChem CID: 16760544 Formula: C24H37NaO6 Molecular Weight: 444.54
    Solid ≥95%
    ● In Stock — US warehouse, ships to EU* Item #: L332296
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    IUPAC Name
    sodium;(3R,5R)-7-[(1S,2S,6R,8S,8aR)-2,6-dimethyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
    SMILES
    CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC(CC(CC(=O)[O-])O)O)C.[Na+]
    InChIKey
    LXZBFUBRYYVRQJ-AXHZAXLDSA-M
    InChI
    1S/C24H38O6.Na/c1-5-15(3)24(29)30-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-18(25)12-19(26)13-22(27)28;/h6-7,10,14-16,18-21,23,25-26H,5,8-9,11-13H2,1-show more
    Synonyms
    1-NAPHTHALENEHEPTANOIC ACID, 1,2,6,7,8,8A-HEXAHYDRO-.BETA.,.DELTA.-DIHYDROXY-2,6-DIMETHYL-8-(2-METHYL-1-OXOBUTOXY)-, ...
  2. rac 5-Keto Fluvastatin
    CAS: 1160169-39-0 PubChem CID: 23112881 Formula: C24H24FNO4 Molecular Weight: 409.45
    ◐ .Made to order · 8–12 wks Item #: R338438
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    IUPAC Name
    (E)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3-hydroxy-5-oxohept-6-enoic acid
    SMILES
    CC(C)N1C2=CC=CC=C2C(=C1C=CC(=O)CC(CC(=O)O)O)C3=CC=C(C=C3)F
    InChIKey
    FSIBOMHNSMFWBF-VAWYXSNFSA-N
    InChI
    1S/C24H24FNO4/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30/h3-12,15,19,28H,13-14H2,1-2H3,(H,29,30)/b12-1show more
    Synonyms
    (6E)-7-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3-hydroxy-5-oxo-6-heptenoic Acid; 5-Ketofluvastatin; Fluv...
  3. Lovastatin, HMG-CoA reductase inhibitor
    CAS: 75330-75-5 EC Number: 692-955-0 Formula: C24H36O5 Molecular Weight: 404.54
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: L107709
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    IUPAC Name
    [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
    SMILES
    CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C
    InChIKey
    PCZOHLXUXFIOCF-BXMDZJJMSA-N
    InChI
    1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14show more
    Synonyms
    1,2,6,7,8,8a-Hexahydro-beta,delta-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobutyoxy)-1-naphthaleneheptanoic acid delta-...
  4. Rosuvastatin Calcium, HMG-CoA reductase inhibitor
    CAS: 147098-20-2 EC Number: 627-028-1 PubChem CID: 5282455 Formula: C22H27FN3O6S·1/2Ca Molecular Weight: 500.57
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ● In Stock — US warehouse, ships to EU* Item #: R129220
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    IUPAC Name
    calcium;(E,3R,5S)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate
    SMILES
    CC(C)C1=NC(=NC(=C1C=CC(CC(CC(=O)[O-])O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C.CC(C)C1=NC(=NC(=C1C=CC(CC(CC(=O)[O-])O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C.[Ca+2]
    InChIKey
    LALFOYNTGMUKGG-BGRFNVSISA-L
    InChI
    1S/2C22H28FN3O6S.Ca/c2*1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32;/h2*5-10,13,16-17,27-28H,11-12Hshow more
    Synonyms
    Shufutan | Suvikan | Provisacor | ROSUVASTATIN CALCIUM (USP-RS) | ROSUVASTATIN CALCIUM [EP MONOGRAPH] | R0180 | EZALL...
  5. Pitavastatin Calcium, HMG-CoA reductase inhibitor
    CAS: 147526-32-7 EC Number: 807-641-2 PubChem CID: 5282451 Formula: C50H46CaF2N2O8 Molecular Weight: 880.98
    ● In Stock — US warehouse, ships to EU* Item #: P129617
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    IUPAC Name
    calcium;(E,3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate
    SMILES
    C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.[Ca+2]
    InChIKey
    RHGYHLPFVJEAOC-FFNUKLMVSA-L
    InChI
    1S/2C25H24FNO4.Ca/c2*26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31;/h2*1-4,7-12,16,18-19,28-29H,5-6,show more
    Synonyms
    (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid hemicalcium salt | Itavas...
  6. Atorvastatin Calcium Salt Trihydrate
    CAS: 344423-98-9 Formula: C66H68CaF2N4O10·3H2O Molecular Weight: 1155.4(as Anhydrous)
    ● In Stock — US warehouse, ships to EU* Item #: A179410
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    IUPAC Name
    calcium;(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate;trihydrate
    SMILES
    CC(C)C1=C(C(=C(N1CCC(CC(CC(=O)[O-])O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4.CC(C)C1=C(C(=C(N1CCC(CC(CC(=O)[O-])O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)show more
    InChIKey
    SHZPNDRIDUBNMH-NIJVSVLQSA-L
    InChI
    1S/2C33H35FN2O5.Ca.3H2O/c2*1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)show more
    Synonyms
    Calcium(3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate...
  7. Atorvastatin calcium salt trihydrate
    CAS: 134523-03-8 PubChem CID: 60822 Formula: C66H68CaF2N4O10 Molecular Weight: 1155.34
    ● In Stock — US warehouse, ships to EU* Item #: A121956
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    IUPAC Name
    calcium;(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate
    SMILES
    CC(C)C1=C(C(=C(N1CCC(CC(CC(=O)[O-])O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4.CC(C)C1=C(C(=C(N1CCC(CC(CC(=O)[O-])O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)show more
    InChIKey
    FQCKMBLVYCEXJB-MNSAWQCASA-L
    InChI
    1S/2C33H35FN2O5.Ca/c2*1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;/hshow more
    Synonyms
    Calcium (betaR,deltaR)-2-(p-fluorophenyl)-beta,delta-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrole-1-hept...
  8. Mevastatin, Inhibitor of hydroxymethylglutaryl-CoA reductase
    CAS: 73573-88-3 EC Number: 700-442-0 Formula: C23H34O5 Molecular Weight: 390.51
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥96%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: M107870
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    IUPAC Name
    [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
    SMILES
    CCC(C)C(=O)OC1CCC=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O
    InChIKey
    AJLFOPYRIVGYMJ-INTXDZFKSA-N
    InChI
    1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15show more
    Synonyms
    Butanoic acid, 2-methyl-, (1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-...
  9. Pravastatin lactone
    CAS: 85956-22-5 PubChem CID: 9931182 Formula: C23H34O6 Molecular Weight: 406.51
    ◐ .Made to order · 8–12 wks Item #: P274681
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    IUPAC Name
    [(1S,3S,7S,8S,8aR)-3-hydroxy-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
    SMILES
    CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)O
    InChIKey
    OQARDMYXSOFTLN-PZAWKZKUSA-N
    InChI
    1S/C23H34O6/c1-4-13(2)23(27)29-20-11-16(24)9-15-6-5-14(3)19(22(15)20)8-7-18-10-17(25)12-21(26)28-18/h5-6,9,13-14,16-20,22,24-25H,4,7-8,10-12H2,1-3H3/tshow more
    Synonyms
    (1S,3S,7S,8S,8aR)-3-Hydroxy-8-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahy...
  10. Pravastatin sodium, HMG-CoA reductase inhibitor
    CAS: 81131-70-6 EC Number: 617-202-5 Formula: C23H35O7Na Molecular Weight: 446.5
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: P107388
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    IUPAC Name
    sodium;(3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
    SMILES
    CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC(CC(CC(=O)[O-])O)O)O.[Na+]
    InChIKey
    VWBQYTRBTXKKOG-IYNICTALSA-M
    InChI
    1S/C23H36O7.Na/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28;/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3show more
    Synonyms
    2-methyl-8-((S)-2-methylbutanoyloxy)-1,2,6,7,8,8a- | CAS-81131-70-6 | HMS3413E20 | HY-B0165AR | Liotrix (t4) | Pravas...
  11. Rosuvastatin-d3 sodium salt
    CAS: 1279031-70-7 PubChem CID: 45359102 Formula: C22H24D3FN3O6S・Na Molecular Weight: 506.54
    ◐ .Made to order · 8–12 wks Item #: R341344
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    IUPAC Name
    sodium;(E,3R,5S)-7-[4-(4-fluorophenyl)-2-[methylsulfonyl(trideuteriomethyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate
    SMILES
    CC(C)C1=NC(=NC(=C1C=CC(CC(CC(=O)[O-])O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C.[Na+]
    InChIKey
    RGEBGDYYHAFODH-SYRJKFITSA-M
    InChI
    1S/C22H28FN3O6S.Na/c1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32;/h5-10,13,16-17,27-28H,11-12H2,1-4show more
    Synonyms
    (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl-d3)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-...
  12. SR-12813, Agonist of Pregnane X receptor
    CAS: 126411-39-0 PubChem CID: 446313 Formula: C24H42O7P2 Molecular Weight: 504.5
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: S274978
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    IUPAC Name
    4-[2,2-bis(diethoxyphosphoryl)ethenyl]-2,6-ditert-butylphenol
    SMILES
    CCOP(=O)(C(=CC1=CC(=C(C(=C1)C(C)(C)C)O)C(C)(C)C)P(=O)(OCC)OCC)OCC
    InChIKey
    YQLJDECYQDRSBI-UHFFFAOYSA-N
    InChI
    1S/C24H42O7P2/c1-11-28-32(26,29-12-2)21(33(27,30-13-3)31-14-4)17-18-15-19(23(5,6)7)22(25)20(16-18)24(8,9)10/h15-17,25H,11-14H2,1-10H3
    Synonyms
    CHEBI:77317 | NCGC00165888-01 | 4-(2,2-BIS(DIETHOXYPHOSPHORYL)ETHENYL)-2,6-DITERT-BUTYLPHENOL | SR-12813GW 485801 | [...
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Frequently Asked Questions

How is the HMG-CoA Reductase (HMGCR) listing put together?
It draws on reported HMG-CoA Reductase (HMGCR) annotations within Metabolic Enzyme/Protease and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose a HMG-CoA Reductase (HMGCR) modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the HMG-CoA Reductase (HMGCR) entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for HMG-CoA Reductase (HMGCR) compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For HMG-CoA Reductase (HMGCR) work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the HMG-CoA Reductase (HMGCR) compound I need is not listed?
Search by CAS number or SMILES first, since analogs of HMG-CoA Reductase (HMGCR) compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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