Metabolic Enzyme/Protease - Isocitrate Dehydrogenase (IDH) Supplier | High Purity

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Enasidenib, Inhibitor of isocitrate dehydrogenase (NADP(+)) 2
CAS: 1446502-11-9 EC Number: 107-597-8 Formula: C₁₉H₁₇F₆N₇O Molecular Weight: 473.4

Moligand™ ? ≥97%

● In Stock — US warehouse, ships to EU* Item #: E174257
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IUPAC Name

2-methyl-1-[[4-[6-(trifluoromethyl)pyridin-2-yl]-6-[[2-(trifluoromethyl)pyridin-4-yl]amino]-1,3,5-triazin-2-yl]amino]propan-2-ol

SMILES

CC(C)(CNC1=NC(=NC(=N1)C2=NC(=CC=C2)C(F)(F)F)NC3=CC(=NC=C3)C(F)(F)F)O

InChIKey
DYLUUSLLRIQKOE-UHFFFAOYSA-N

InChI

1S/C19H17F6N7O/c1-17(2,33)9-27-15-30-14(11-4-3-5-12(29-11)18(20,21)22)31-16(32-15)28-10-6-7-26-13(8-10)19(23,24)25/h3-8,33H,9H2,1-2H3,(H2,26,27,28,30,show more

Synonyms
1802003-09-3 | Enasidenib [USAN:INN] | IDHIFA | SCHEMBL15102202 | 2-methyl-1-[[4-[6-(trifluoromethyl)pyridin-2-yl]-6-...
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AG-120, Isocitrate dehydrogenase [NADP] cytoplasmic inhibitor
CAS: 1448347-49-6 Formula: C₂₈H₂₂ClF₃N₆O₃ Molecular Weight: 582.96

Moligand™ ? ≥98%

● In Stock — US warehouse, ships to EU* Item #: A302896
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IUPAC Name

(2S)-N-[(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl]-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carbshow more

SMILES

C1CC(=O)N(C1C(=O)N(C2=CC(=CN=C2)F)C(C3=CC=CC=C3Cl)C(=O)NC4CC(C4)(F)F)C5=NC=CC(=C5)C#N

InChIKey
WIJZXSAJMHAVGX-DHLKQENFSA-N

InChI

1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1show more

Synonyms
Ivosidenib (USAN/INN) | AC-32624 | US9850277, Compound 176 | (2S)-N-{(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobut...
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TC-E 5008
CAS: 50405-58-8 PubChem CID: 13590964 Formula: C₁₃H₁₃NO₂ Molecular Weight: 215.25

◐ .Made to order · 8–12 wks Item #: T288914
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IUPAC Name

6-benzyl-1-hydroxy-4-methylpyridin-2-one

SMILES

CC1=CC(=O)N(C(=C1)CC2=CC=CC=C2)O

InChIKey
AVLZAVSZOAQKRC-UHFFFAOYSA-N

InChI

1S/C13H13NO2/c1-10-7-12(14(16)13(15)8-10)9-11-5-3-2-4-6-11/h2-8,16H,9H2,1H3

Synonyms
SYC 435 | 1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone
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AGI-5198, Inhibitor of isocitrate dehydrogenase (NADP(+)) 1
CAS: 1355326-35-0 EC Number: 806-071-1 Formula: C₂₇H₃₁FN₄O₂ Molecular Weight: 462.56

Moligand™ ? ≥98%

● In Stock — US warehouse, ships to EU* Item #: A126546
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IUPAC Name

N-cyclohexyl-2-(3-fluoro-N-[2-(2-methylimidazol-1-yl)acetyl]anilino)-2-(2-methylphenyl)acetamide

SMILES

CC1=CC=CC=C1C(C(=O)NC2CCCCC2)N(C3=CC(=CC=C3)F)C(=O)CN4C=CN=C4C

InChIKey
FNYGWXSATBUBER-UHFFFAOYSA-N

InChI

1S/C27H31FN4O2/c1-19-9-6-7-14-24(19)26(27(34)30-22-11-4-3-5-12-22)32(23-13-8-10-21(28)17-23)25(33)18-31-16-15-29-20(31)2/h6-10,13-17,22,26H,3-5,11-12,show more

Synonyms
HMS3653K15 | N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-o-tolylacetamide | AKOS0266...
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AGI-6780
CAS: 1432660-47-3 Formula: C₂₁H₁₈F₃N₃O₃S₂ Molecular Weight: 481.51

≥98%

● In Stock — US warehouse, ships to EU* Item #: A124933
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IUPAC Name

1-[5-(cyclopropylsulfamoyl)-2-thiophen-3-ylphenyl]-3-[3-(trifluoromethyl)phenyl]urea

SMILES

C1CC1NS(=O)(=O)C2=CC(=C(C=C2)C3=CSC=C3)NC(=O)NC4=CC=CC(=C4)C(F)(F)F

InChIKey
CCAWRGNYALGPQH-UHFFFAOYSA-N

InChI

1S/C21H18F3N3O3S2/c22-21(23,24)14-2-1-3-16(10-14)25-20(28)26-19-11-17(32(29,30)27-15-4-5-15)6-7-18(19)13-8-9-31-12-13/h1-3,6-12,15,27H,4-5H2,(H2,25,26show more

Synonyms
AC-35210 | AGI 6780 | SW220033-1 | N-cyclopropyl-4-(thiophen-3-yl)-3-(3-(3-(trifluoromethyl)phenyl)ureido)benzenesulf...
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Vorasidenib (AG-881), IDH1/IDH2 inhibitor
CAS: 1644545-52-7 PubChem CID: 117817422 Formula: C₁₄H₁₃ClF₆N₆ Molecular Weight: 414.74

Moligand™ ? ≥98%

● In Stock — US warehouse, ships to EU* Item #: V305105
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Technical Identifiers

IUPAC Name

6-(6-chloropyridin-2-yl)-2-N,4-N-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine

SMILES

CC(C(F)(F)F)NC1=NC(=NC(=N1)C2=NC(=CC=C2)Cl)NC(C)C(F)(F)F

InChIKey
QCZAWDGAVJMPTA-RNFRBKRXSA-N

InChI

1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)/t6-,7-/m1/s1

Synonyms
6-(6-chloropyridin-2-yl)-2-N,4-N-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine | AG 881 [WHO-DD] | ...
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AG-120 (racemic)
CAS: 1448346-63-1 Formula: C₂₈H₂₂ClF₃N₆O₃ Molecular Weight: 582.96

10mM in DMSO

● In Stock — US warehouse, ships to EU* Item #: A421656
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IUPAC Name

(2S)-N-[1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl]-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamishow more

SMILES

C1CC(=O)N(C1C(=O)N(C2=CC(=CN=C2)F)C(C3=CC=CC=C3Cl)C(=O)NC4CC(C4)(F)F)C5=NC=CC(=C5)C#N

InChIKey
WIJZXSAJMHAVGX-XADRRFQNSA-N

InChI

1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1show more

Synonyms
Glycinamide,1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-...
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AG-120 (racemic)
CAS: 1448346-63-1 Formula: C₂₈H₂₂ClF₃N₆O₃ Molecular Weight: 582.96

≥98%

● In Stock — US warehouse, ships to EU* Item #: A412505
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Technical Identifiers

IUPAC Name

(2S)-N-[1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl]-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamishow more

SMILES

C1CC(=O)N(C1C(=O)N(C2=CC(=CN=C2)F)C(C3=CC=CC=C3Cl)C(=O)NC4CC(C4)(F)F)C5=NC=CC(=C5)C#N

InChIKey
WIJZXSAJMHAVGX-XADRRFQNSA-N

InChI

1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1show more

Synonyms
Glycinamide,1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-...
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AGI-5198, Inhibitor of isocitrate dehydrogenase (NADP(+)) 1
CAS: 1355326-35-0 EC Number: 806-071-1 Formula: C₂₇H₃₁FN₄O₂ Molecular Weight: 462.56

Moligand™ ? 10mM in DMSO

● In Stock — US warehouse, ships to EU* Item #: A421351
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Technical Identifiers

IUPAC Name

N-cyclohexyl-2-(3-fluoro-N-[2-(2-methylimidazol-1-yl)acetyl]anilino)-2-(2-methylphenyl)acetamide

SMILES

CC1=CC=CC=C1C(C(=O)NC2CCCCC2)N(C3=CC(=CC=C3)F)C(=O)CN4C=CN=C4C

InChIKey
FNYGWXSATBUBER-UHFFFAOYSA-N

InChI

1S/C27H31FN4O2/c1-19-9-6-7-14-24(19)26(27(34)30-22-11-4-3-5-12-22)32(23-13-8-10-21(28)17-23)25(33)18-31-16-15-29-20(31)2/h6-10,13-17,22,26H,3-5,11-12,show more

Synonyms
HMS3653K15 | N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-o-tolylacetamide | AKOS0266...
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AGI-6780
CAS: 1432660-47-3 Formula: C₂₁H₁₈F₃N₃O₃S₂ Molecular Weight: 481.51

10mM in DMSO

● In Stock — US warehouse, ships to EU* Item #: A421598
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Technical Identifiers

IUPAC Name

1-[5-(cyclopropylsulfamoyl)-2-thiophen-3-ylphenyl]-3-[3-(trifluoromethyl)phenyl]urea

SMILES

C1CC1NS(=O)(=O)C2=CC(=C(C=C2)C3=CSC=C3)NC(=O)NC4=CC=CC(=C4)C(F)(F)F

InChIKey
CCAWRGNYALGPQH-UHFFFAOYSA-N

InChI

1S/C21H18F3N3O3S2/c22-21(23,24)14-2-1-3-16(10-14)25-20(28)26-19-11-17(32(29,30)27-15-4-5-15)6-7-18(19)13-8-9-31-12-13/h1-3,6-12,15,27H,4-5H2,(H2,25,26show more

Synonyms
AC-35210 | AGI 6780 | SW220033-1 | N-cyclopropyl-4-(thiophen-3-yl)-3-(3-(3-(trifluoromethyl)phenyl)ureido)benzenesulf...
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BAY 1436032, Isocitrate dehydrogenase [NADP] cytoplasmic inhibitor
CAS: 1803274-65-8 Formula: C₂₆H₃₀F₃N₃O₃ Molecular Weight: 489.53

Solid Moligand™ ? ≥98%

◐ .Made to order · 8–12 wks Item #: B414041
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Technical Identifiers

IUPAC Name

3-[2-[4-(trifluoromethoxy)anilino]-1-[(1R,5R)-3,3,5-trimethylcyclohexyl]benzimidazol-5-yl]propanoic acid

SMILES

CC1CC(CC(C1)(C)C)N2C3=C(C=C(C=C3)CCC(=O)O)N=C2NC4=CC=C(C=C4)OC(F)(F)F

InChIKey
RNMAUIMMNAHKQR-QFBILLFUSA-N

InChI

1S/C26H30F3N3O3/c1-16-12-19(15-25(2,3)14-16)32-22-10-4-17(5-11-23(33)34)13-21(22)31-24(32)30-18-6-8-20(9-7-18)35-26(27,28)29/h4,6-10,13,16,19H,5,11-12show more

Synonyms
BAY-1436032 | US10344004, Test compound Table 3 | SCHEMBL17009632 | BAY 1436032 | s8530 | 3-(2-((4-(trifluoromethoxy)...
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DS-1001b (DS 1001), Isocitrate dehydrogenase [NADP] cytoplasmic inhibitor
CAS: 1898207-64-1 PubChem CID: 139600317 Formula: C₂₉H₂₉Cl₃FN₃O₄ Molecular Weight: 608.92

≥98%

● In Stock — US warehouse, ships to EU* Item #: D414241
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IUPAC Name

(E)-3-[1-[5-(2-fluoropropan-2-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazole-4-carbonyl]-3-methylindol-4-yl]prop-2-enoic acid;2-methylpropan-2-amine

SMILES

CC1=CN(C2=CC=CC(=C12)C=CC(=O)O)C(=O)C3=C(ON=C3C4=C(C=C(C=C4Cl)Cl)Cl)C(C)(C)F.CC(C)(C)N

InChIKey
UPPAAWQBZQBNIE-USRGLUTNSA-N

InChI

1S/C25H18Cl3FN2O4.C4H11N/c1-12-11-31(17-6-4-5-13(19(12)17)7-8-18(32)33)24(34)21-22(30-35-23(21)25(2,3)29)20-15(27)9-14(26)10-16(20)28;1-4(2,3)5/h4-11Hshow more

Synonyms
C29H29Cl3FN3O4 | 2-Methylpropan-2-amine (E)-3-(1-(5-(2-fluoropropan-2-yl)-3-(2,4,6-trichlorophenyl)isoxazole-4-carbon...

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Frequently Asked Questions

What can I find under Isocitrate Dehydrogenase (IDH)?

This listing collects compounds associated with Isocitrate Dehydrogenase (IDH) within our Metabolic Enzyme/Protease area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.

What should I consider when picking a compound for Isocitrate Dehydrogenase (IDH)?

Consider the reported potency of each Isocitrate Dehydrogenase (IDH) compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.

What quality information is provided for Isocitrate Dehydrogenase (IDH) compounds?

Each Isocitrate Dehydrogenase (IDH) product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.

Can I search Isocitrate Dehydrogenase (IDH) compounds by activity or structure?

Yes. Filter the Isocitrate Dehydrogenase (IDH) listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].