Ketohexokinase

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  1. Ketohexokinase inhibitor 1
    CAS: 2102501-84-6 PubChem CID: 129278694 Formula: C16H19F3N4O2 Molecular Weight: 356.34
    ◐ .Made to order · 8–12 wks Item #: K669283
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    IUPAC Name
    2-[(1S,5R)-3-[2-[(2S)-2-methylazetidin-1-yl]-6-(trifluoromethyl)pyrimidin-4-yl]-3-azabicyclo[3.1.0]hexan-6-yl]acetic acid
    SMILES
    CC1CCN1C2=NC(=CC(=N2)N3CC4C(C3)C4CC(=O)O)C(F)(F)F
    InChIKey
    MDUYWDNWFXSMJJ-OFLUOSHYSA-N
    InChI
    1S/C16H19F3N4O2/c1-8-2-3-23(8)15-20-12(16(17,18)19)5-13(21-15)22-6-10-9(4-14(24)25)11(10)7-22/h5,8-11H,2-4,6-7H2,1H3,(H,24,25)/t8-,9?,10-,11+/m0/s1
    Synonyms
    Ketohexokinase inhibitor 1 | PF-06835919 | 2-[(1~{S},5~{R})-3-[2-[(2~{S})-2-methylazetidin-1-yl]-6-(trifluoromethyl)p...
  2. Khk-IN-1
    CAS: 1303469-70-6 PubChem CID: 53348216 Formula: C21H26N8S Molecular Weight: 422.6
    ◐ .Made to order · 8–12 wks Item #: K669262
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    IUPAC Name
    8-N-(cyclopropylmethyl)-4-N-(2-methylsulfanylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamine
    SMILES
    CSC1=CC=CC=C1NC2=NC(=NC3=C2N=CN=C3NCC4CC4)N5CCNCC5
    InChIKey
    HFLMLZKGLUEWBU-UHFFFAOYSA-N
    InChI
    1S/C21H26N8S/c1-30-16-5-3-2-4-15(16)26-20-17-18(19(25-13-24-17)23-12-14-6-7-14)27-21(28-20)29-10-8-22-9-11-29/h2-5,13-14,22H,6-12H2,1H3,(H,23,24,25)(Hshow more
    Synonyms
    KHK-IN-1 | KHK-IN-8 | N~8~-(Cyclopropylmethyl)-N~4~-[2-(Methylsulfanyl)phenyl]-2-(Piperazin-1-Yl)pyrimido[5,4-D]pyrim...
  3. KHK-IN-1 hydrochloride
    CAS: 1303470-48-5 PubChem CID: 92044374 Formula: C21H27ClN8S Molecular Weight: 459
    ◐ .Made to order · 8–12 wks Item #: K1000982
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    IUPAC Name
    8-N-(cyclopropylmethyl)-4-N-(2-methylsulfanylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamine;hydrochloride
    SMILES
    CSC1=CC=CC=C1NC2=NC(=NC3=C2N=CN=C3NCC4CC4)N5CCNCC5.Cl
    InChIKey
    VKIBPWKARAEIHN-UHFFFAOYSA-N
    InChI
    1S/C21H26N8S.ClH/c1-30-16-5-3-2-4-15(16)26-20-17-18(19(25-13-24-17)23-12-14-6-7-14)27-21(28-20)29-10-8-22-9-11-29;/h2-5,13-14,22H,6-12H2,1H3,(H,23,24,show more
  4. LY3522348
    CAS: 2568608-48-8 Formula: C18H22F3N7O Molecular Weight: 409.41
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10 mM in DMSO
    ◐ .Made to order · 8–12 wks Item #: L1497640
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  5. PF-06835919
    CAS: 2102501-84-6 PubChem CID: 129278694 Formula: C16H19F3N4O2 Molecular Weight: 356.34
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10 mM in DMSO
    ◐ .Made to order · 8–12 wks Item #: P1500109
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  6. KHK-IN-2
    CAS: 2135304-43-5 Formula: C16H19F3N4O3 Molecular Weight: 372.34
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10 mM in DMSO
    ◐ .Made to order · 8–12 wks Item #: K1493684
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R&D Use Only Products supplied for research and development use

Frequently Asked Questions

What can I find under Ketohexokinase?
This listing collects compounds associated with Ketohexokinase within our Metabolic Enzyme/Protease area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.
What should I consider when picking a compound for Ketohexokinase?
Consider the reported potency of each Ketohexokinase compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.
What quality information is provided for Ketohexokinase compounds?
Each Ketohexokinase product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search Ketohexokinase compounds by activity or structure?
Yes. Filter the Ketohexokinase listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].

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