LXR

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  1. GSK 2033, Antagonist of Liver X receptor-α;Antagonist of Liver X receptor-β
    CAS: 1221277-90-2 Formula: C29H28F3NO5S2 Molecular Weight: 591.66
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥96%
    ● In Stock — US warehouse, ships to EU* Item #: G288522
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    IUPAC Name
    2,4,6-trimethyl-N-[[4-(3-methylsulfonylphenyl)phenyl]methyl]-N-[[5-(trifluoromethyl)furan-2-yl]methyl]benzenesulfonamide
    SMILES
    CC1=CC(=C(C(=C1)C)S(=O)(=O)N(CC2=CC=C(C=C2)C3=CC(=CC=C3)S(=O)(=O)C)CC4=CC=C(O4)C(F)(F)F)C
    InChIKey
    PSOXOVKYGWBTPB-UHFFFAOYSA-N
    InChI
    1S/C29H28F3NO5S2/c1-19-14-20(2)28(21(3)15-19)40(36,37)33(18-25-12-13-27(38-25)29(30,31)32)17-22-8-10-23(11-9-22)24-6-5-7-26(16-24)39(4,34)35/h5-16H,17show more
    Synonyms
    GSK2033 | 2,4,6-Trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methy...
  2. GW3965 HCl
    CAS: 405911-17-3 EC Number: 637-023-6 Formula: C33H31ClF3NO3.HCl Molecular Weight: 618.51
    ● In Stock — US warehouse, ships to EU* Item #: G129708
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    IUPAC Name
    2-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-(2,2-diphenylethyl)amino]propoxy]phenyl]acetic acid;hydrochloride
    SMILES
    C1=CC=C(C=C1)C(CN(CCCOC2=CC=CC(=C2)CC(=O)O)CC3=C(C(=CC=C3)C(F)(F)F)Cl)C4=CC=CC=C4.Cl
    InChIKey
    NMPUWJFHNOUNQU-UHFFFAOYSA-N
    InChI
    1S/C33H31ClF3NO3.ClH/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26;/hshow more
    Synonyms
    GW3965 HCl | MLS006011227 | 2-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-(2,2-diphenylethyl)amino]propoxy]phe...
  3. SR 9243
    CAS: 1613028-81-1 PubChem CID: 76073169 Formula: C31H32BrNO4S2 Molecular Weight: 626.62
    ● In Stock — US warehouse, ships to EU* Item #: S288886
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    IUPAC Name
    N-[2-(3-bromophenyl)ethyl]-2,4,6-trimethyl-N-[[4-(3-methylsulfonylphenyl)phenyl]methyl]benzenesulfonamide
    SMILES
    CC1=CC(=C(C(=C1)C)S(=O)(=O)N(CCC2=CC(=CC=C2)Br)CC3=CC=C(C=C3)C4=CC(=CC=C4)S(=O)(=O)C)C
    InChIKey
    FYQFEJFTCLKXTQ-UHFFFAOYSA-N
    InChI
    1S/C31H32BrNO4S2/c1-22-17-23(2)31(24(3)18-22)39(36,37)33(16-15-25-7-5-9-29(32)19-25)21-26-11-13-27(14-12-26)28-8-6-10-30(20-28)38(4,34)35/h5-14,17-20Hshow more
    Synonyms
    N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]benzenesulfonamide
  4. Acetyl Podocarpic Acid Anhydride, Agonist of Liver X receptor-α;Agonist of Liver X receptor-β
    CAS: 344327-48-6 PubChem CID: 9830426 Formula: C38H46O7 Molecular Weight: 614.75
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: A346580
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    IUPAC Name
    [(1S,4aS,10aR)-6-acetyloxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carbonyl] (1S,4aS,10aR)-6-acetyloxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahshow more
    SMILES
    CC(=O)OC1=CC2=C(CCC3C2(CCCC3(C)C(=O)OC(=O)C4(CCCC5(C4CCC6=C5C=C(C=C6)OC(=O)C)C)C)C)C=C1
    InChIKey
    OUJQRQRBNRGQTC-SPGSYPTKSA-N
    InChI
    1S/C38H46O7/c1-23(39)43-27-13-9-25-11-15-31-35(3,29(25)21-27)17-7-19-37(31,5)33(41)45-34(42)38(6)20-8-18-36(4)30-22-28(44-24(2)40)14-10-26(30)12-16-32show more
    Synonyms
    acetyl-podocarpic dimer
  5. Taraxasterol
    CAS: 1059-14-9 PubChem CID: 115250 Formula: C30H50O Molecular Weight: 426.73
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
    ● In Stock — US warehouse, ships to EU* Item #: T299477
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    IUPAC Name
    (3S,4aR,6aR,6aR,6bR,8aR,12S,12aR,14aR,14bR)-4,4,6a,6b,8a,12,14b-heptamethyl-11-methylidene-1,2,3,4a,5,6,6a,7,8,9,10,12,12a,13,14,14a-hexadecahydropiceshow more
    SMILES
    CC1C2C3CCC4C5(CCC(C(C5CCC4(C3(CCC2(CCC1=C)C)C)C)(C)C)O)C
    InChIKey
    XWMMEBCFHUKHEX-ZJJHUPNDSA-N
    InChI
    1S/C30H50O/c1-19-11-14-27(5)17-18-29(7)21(25(27)20(19)2)9-10-23-28(6)15-13-24(31)26(3,4)22(28)12-16-30(23,29)8/h20-25,31H,1,9-18H2,2-8H3/t20-,21-,22+,show more
    Synonyms
    LMPR0106180006 | (3.BETA.,18.ALPHA.,19.ALPHA.)-URS-20(30)-EN-3-OL | EN300-122379 | EX-A8003F | 2-METHYL-5-(MORPHOLINO...
  6. SR 9238, Antagonist of Liver X receptor-α;Antagonist of Liver X receptor-β
    CAS: 1416153-62-2 PubChem CID: 71478195 Formula: C31H33NO7S2 Molecular Weight: 595.73
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: S288664
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    IUPAC Name
    ethyl 5-[[[4-(3-methylsulfonylphenyl)phenyl]methyl-(2,4,6-trimethylphenyl)sulfonylamino]methyl]furan-2-carboxylate
    SMILES
    CCOC(=O)C1=CC=C(O1)CN(CC2=CC=C(C=C2)C3=CC(=CC=C3)S(=O)(=O)C)S(=O)(=O)C4=C(C=C(C=C4C)C)C
    InChIKey
    HDZWHJYZJWLTAG-UHFFFAOYSA-N
    InChI
    1S/C31H33NO7S2/c1-6-38-31(33)29-15-14-27(39-29)20-32(41(36,37)30-22(3)16-21(2)17-23(30)4)19-24-10-12-25(13-11-24)26-8-7-9-28(18-26)40(5,34)35/h7-18H,6show more
    Synonyms
    Ethyl 5-((2,4,6-trimethyl-N-((3′-(methylsulfonyl)-[1,1′-biphenyl]-4-yl)methyl)phenylsulfonamido)methyl)furan-2-carbox...
  7. T0901317, Agonist of Liver X receptor-α;Agonist of Liver X receptor-β;Agonist of RAR-related orphan receptor-α;Agonist of RAR-related orphan receptor-γ
    CAS: 293754-55-9 PubChem CID: 447912 Formula: C17H12F9NO3S Molecular Weight: 481.33
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: T129709
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    Technical Identifiers
    IUPAC Name
    N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide
    SMILES
    C1=CC=C(C=C1)S(=O)(=O)N(CC(F)(F)F)C2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O
    InChIKey
    SGIWFELWJPNFDH-UHFFFAOYSA-N
    InChI
    1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2
    Synonyms
    T-0901317 | T 0901317 | N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(2,2,2-trifluoroethyl)benzenesulf...
  8. LXR-623, LXR-alpha agonist
    CAS: 875787-07-8 EC Number: 809-610-9 PubChem CID: 16734800 Formula: C21H12ClF5N2 Molecular Weight: 422.78
    ● In Stock — US warehouse, ships to EU* Item #: W287754
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    IUPAC Name
    2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)indazole
    SMILES
    C1=CC2=C(N(N=C2C(=C1)C(F)(F)F)CC3=C(C=C(C=C3)F)Cl)C4=CC=C(C=C4)F
    InChIKey
    KYWWJENKIMRJBI-UHFFFAOYSA-N
    InChI
    1S/C21H12ClF5N2/c22-18-10-15(24)9-6-13(18)11-29-20(12-4-7-14(23)8-5-12)16-2-1-3-17(19(16)28-29)21(25,26)27/h1-10H,11H2
    Synonyms
    SY253364 | AS-74262 | C21H12ClF5N2 | LXR-623 (WAY-252623) | s2685 | AKOS015848578 | WAY 252623 | HY-10629 | Q27260593...
  9. cholest-5-ene-3β,24(S)-diol, Agonist of Liver X receptor-α;Agonist of Liver X receptor-β
    CAS: 474-73-7 Formula: C27H46O2 Molecular Weight: 402.653
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ◐ .Made to order · 8–12 wks Item #: C130207
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    IUPAC Name
    (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,5S)-5-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenantshow more
    SMILES
    CC(C)C(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)O
    InChIKey
    IOWMKBFJCNLRTC-XWXSNNQWSA-N
    InChI
    1S/C27H46O2/c1-17(2)25(29)11-6-18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20+,2show more
    Synonyms
    CHEBI:34310 | 24(S)-hydroxycholesterol | 24S-Cholest-5-ene-3b,24-diol | Cerebrosterin | (3beta,4alpha)-Cholest-5-ene-...
  10. cholest-(25R)-5-ene-3β,27-diol, Agonist of GPR183;Agonist of Liver X receptor-α;Agonist of Liver X receptor-β
    CAS: 20380-11-4 Formula: C27H46O2 Molecular Weight: 402.65
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ● In Stock — US warehouse, ships to EU* Item #: C130177
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    IUPAC Name
    (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,6R)-7-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenantshow more
    SMILES
    CC(CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)CO
    InChIKey
    FYHRJWMENCALJY-YSQMORBQSA-N
    InChI
    1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18-,19-show more
    Synonyms
    27-OHC | (25R) | 110818 | Cholest-5-ene-3-b,27-diol | PD018880 | CHOLEST-5-ENE-3.BETA.,26-DIOL, (25R)- | EX-A7666 | (...
  11. (20S)-Protopanaxatriol
    CAS: 34080-08-5 Formula: C30H52O4 Molecular Weight: 476.73
    ● In Stock — US warehouse, ships to EU* Item #: S303478
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    Technical Identifiers
    IUPAC Name
    (3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cshow more
    SMILES
    CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CC(C4C3(CCC(C4(C)C)O)C)O)C)O)C)O)C
    InChIKey
    SHCBCKBYTHZQGZ-CJPZEJHVSA-N
    InChI
    1S/C30H52O4/c1-18(2)10-9-13-30(8,34)19-11-15-28(6)24(19)20(31)16-22-27(5)14-12-23(33)26(3,4)25(27)21(32)17-29(22,28)7/h10,19-25,31-34H,9,11-17H2,1-8H3show more
    Synonyms
    CHEBI:75951 | protopanaxatriol-type ginsenoside aglycone | Protopanaxatriol | 3-Deoxy-3-oxo-20(S)-protopanaxatriol; 3...
  12. (20S)-Protopanaxatriol
    CAS: 34080-08-5 Formula: C30H52O4 Molecular Weight: 476.73
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: S423481
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    Technical Identifiers
    IUPAC Name
    (3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cshow more
    SMILES
    CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CC(C4C3(CCC(C4(C)C)O)C)O)C)O)C)O)C
    InChIKey
    SHCBCKBYTHZQGZ-CJPZEJHVSA-N
    InChI
    1S/C30H52O4/c1-18(2)10-9-13-30(8,34)19-11-15-28(6)24(19)20(31)16-22-27(5)14-12-23(33)26(3,4)25(27)21(32)17-29(22,28)7/h10,19-25,31-34H,9,11-17H2,1-8H3show more
    Synonyms
    (20S)-Protopanaxatriol|34080-08-5|Protopanaxatriol|Protopanaxtriol|20(S)-protopanaxatriol|20S-Protopanaxatriol|g-PPT|...
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Frequently Asked Questions

What can I find under LXR?
This listing collects compounds associated with LXR within our Vitamin D Related/Nuclear Receptor area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.
What should I consider when picking a compound for LXR?
Consider the reported potency of each LXR compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.
What quality information is provided for LXR compounds?
Each LXR product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search LXR compounds by activity or structure?
Yes. Filter the LXR listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].

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