MAGL

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  1. SA 57, Inhibitor of αβ-Hydrolase 6;Inhibitor of Fatty acid amide hydrolase;Inhibitor of Monoacylglycerol lipase
    CAS: 1346169-63-8 PubChem CID: 44589122 Formula: C17H23ClN2O3 Molecular Weight: 338.83
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Made to order · 8–12 wks Item #: S287063
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    IUPAC Name
    [2-(methylamino)-2-oxoethyl] 4-[2-(4-chlorophenyl)ethyl]piperidine-1-carboxylate
    SMILES
    CNC(=O)COC(=O)N1CCC(CC1)CCC2=CC=C(C=C2)Cl
    InChIKey
    JFSSVCSHPDLFCM-UHFFFAOYSA-N
    InChI
    1S/C17H23ClN2O3/c1-19-16(21)12-23-17(22)20-10-8-14(9-11-20)3-2-13-4-6-15(18)7-5-13/h4-7,14H,2-3,8-12H2,1H3,(H,19,21)
    Synonyms
    4-[2-(4-Chlorophenyl)ethyl]-1-piperidinecarboxylic acid 2-(methylamino)-2-oxoethyl ester | (Z)-2-((4-(4-chloropheneth...
  2. WWL 123
    CAS: 1338574-83-6 PubChem CID: 90209976 Formula: C28H24N2O3 Molecular Weight: 436.5
    ● In Stock — US warehouse, ships to EU* Item #: W287695
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    IUPAC Name
    [4-(4-carbamoylphenyl)phenyl] N-methyl-N-[(3-phenylphenyl)methyl]carbamate
    SMILES
    CN(CC1=CC(=CC=C1)C2=CC=CC=C2)C(=O)OC3=CC=C(C=C3)C4=CC=C(C=C4)C(=O)N
    InChIKey
    UUJGYRHAOHORFC-UHFFFAOYSA-N
    InChI
    1S/C28H24N2O3/c1-30(19-20-6-5-9-25(18-20)21-7-3-2-4-8-21)28(32)33-26-16-14-23(15-17-26)22-10-12-24(13-11-22)27(29)31/h2-18H,19H2,1H3,(H2,29,31)
    Synonyms
    N-[[1,1'-Biphenyl]-3-ylmethyl)-N-methylcarbamic acid 4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl ester
  3. 7-HC-arachidonate
    CAS: 161180-11-6 PubChem CID: 35025479 Formula: C29H36O4 Molecular Weight: 448.59
    ◐ .US Made to order · 2–4 wks Item #: H331434
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    IUPAC Name
    (2-oxochromen-7-yl) (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
    SMILES
    CCCCCC=CCC=CCC=CCC=CCCCC(=O)OC1=CC2=C(C=C1)C=CC(=O)O2
    InChIKey
    SFTGFGOBCQCZDY-DOFZRALJSA-N
    InChI
    1S/C29H36O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-28(30)32-26-22-20-25-21-23-29(31)33-27(25)24-26/h6-7,9-10,12-13,15-16,20-24H,2-5,8,11,14,show more
    Synonyms
    Umbelliferyl Arachidonate | 5Z,8Z,11Z,14Z-Eicosatetraenoic acid 2-oxo-2H-1-benzopyran-7-yl ester | 7-Hydroxycoumariny...
  4. JZP 361
    CAS: 1680193-80-9 Formula: C22H20ClN5O Molecular Weight: 405.88
    ● In Stock — US warehouse, ships to EU* Item #: J287969
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    IUPAC Name
    [4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidin-1-yl]-(1,2,4-triazol-1-yl)methanone
    SMILES
    C1CC2=C(C=CC(=C2)Cl)C(=C3CCN(CC3)C(=O)N4C=NC=N4)C5=C1C=CC=N5
    InChIKey
    GAVZCGTYRWKKDV-UHFFFAOYSA-N
    InChI
    1S/C22H20ClN5O/c23-18-5-6-19-17(12-18)4-3-16-2-1-9-25-21(16)20(19)15-7-10-27(11-8-15)22(29)28-14-24-13-26-28/h1-2,5-6,9,12-14H,3-4,7-8,10-11H2
    Synonyms
    [4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl]-1H-1,2,4-triazol-1-ylmetha...
  5. KML 29, Inhibitor of Monoacylglycerol lipase
    CAS: 1380424-42-9 Formula: C24H21F6NO7 Molecular Weight: 549.42
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥96%
    ● In Stock — US warehouse, ships to EU* Item #: K287859
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    IUPAC Name
    1,1,1,3,3,3-hexafluoropropan-2-yl 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate
    SMILES
    C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC(C(F)(F)F)C(F)(F)F
    InChIKey
    SXHQLPHDBLTFPM-UHFFFAOYSA-N
    InChI
    1S/C24H21F6NO7/c25-23(26,27)20(24(28,29)30)38-21(32)31-7-5-13(6-8-31)22(33,14-1-3-16-18(9-14)36-11-34-16)15-2-4-17-19(10-15)37-12-35-17/h1-4,9-10,13,2show more
    Synonyms
    US9133148, 1a | 1,1,1,3,3,3-hexafluoropropan-2-yl 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate...
  6. JW 642
    CAS: 1416133-89-5 Formula: C21H20F6N2O3 Molecular Weight: 462.39
    ● In Stock — US warehouse, ships to EU* Item #: J288364
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    IUPAC Name
    1,1,1,3,3,3-hexafluoropropan-2-yl 4-[(3-phenoxyphenyl)methyl]piperazine-1-carboxylate
    SMILES
    C1CN(CCN1CC2=CC(=CC=C2)OC3=CC=CC=C3)C(=O)OC(C(F)(F)F)C(F)(F)F
    InChIKey
    AVSCNEOUWSVZEY-UHFFFAOYSA-N
    InChI
    1S/C21H20F6N2O3/c22-20(23,24)18(21(25,26)27)32-19(30)29-11-9-28(10-12-29)14-15-5-4-8-17(13-15)31-16-6-2-1-3-7-16/h1-8,13,18H,9-12,14H2
    Synonyms
    4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester | BDBM179950 |...
  7. JZL195, Inhibitor of acyloxyacyl hydrolase;Inhibitor of Fatty acid amide hydrolase;Inhibitor of Monoacylglycerol lipase
    CAS: 1210004-12-8 Formula: C24H23N3O5 Molecular Weight: 433.5
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: J276066
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    Technical Identifiers
    IUPAC Name
    (4-nitrophenyl) 4-[(3-phenoxyphenyl)methyl]piperazine-1-carboxylate
    SMILES
    C1CN(CCN1CC2=CC(=CC=C2)OC3=CC=CC=C3)C(=O)OC4=CC=C(C=C4)[N+](=O)[O-]
    InChIKey
    QNYRAEKLMNDRFY-UHFFFAOYSA-N
    InChI
    1S/C24H23N3O5/c28-24(32-22-11-9-20(10-12-22)27(29)30)26-15-13-25(14-16-26)18-19-5-4-8-23(17-19)31-21-6-2-1-3-7-21/h1-12,17H,13-16,18H2
    Synonyms
    DTXSID401029877 | FT-0700116 | GTPL8606 | 4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate | AC-36809 | ZINC...
  8. JZP 430
    CAS: 1672691-74-5 Formula: C16H26N4O3S Molecular Weight: 354.47
    ● In Stock — US warehouse, ships to EU* Item #: J287504
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    IUPAC Name
    (4-morpholin-4-yl-1,2,5-thiadiazol-3-yl) N-cyclooctyl-N-methylcarbamate
    SMILES
    CN(C1CCCCCCC1)C(=O)OC2=NSN=C2N3CCOCC3
    InChIKey
    WKSHMJCYWFOADB-UHFFFAOYSA-N
    InChI
    1S/C16H26N4O3S/c1-19(13-7-5-3-2-4-6-8-13)16(21)23-15-14(17-24-18-15)20-9-11-22-12-10-20/h13H,2-12H2,1H3
    Synonyms
    4-(4-Morpholinyl)-1,2,5-thiadiazol-3-ylN-cyclooctyl-N-methylcarbamate
  9. WWL 70, Inhibitor of αβ-Hydrolase 6
    CAS: 947669-91-2 PubChem CID: 17759121 Formula: C27H23N3O3 Molecular Weight: 437.49
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: W288650
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    IUPAC Name
    [4-(4-carbamoylphenyl)phenyl] N-methyl-N-[(3-pyridin-4-ylphenyl)methyl]carbamate
    SMILES
    CN(CC1=CC(=CC=C1)C2=CC=NC=C2)C(=O)OC3=CC=C(C=C3)C4=CC=C(C=C4)C(=O)N
    InChIKey
    QTWNORFUQILKJL-UHFFFAOYSA-N
    InChI
    1S/C27H23N3O3/c1-30(18-19-3-2-4-24(17-19)22-13-15-29-16-14-22)27(32)33-25-11-9-21(10-12-25)20-5-7-23(8-6-20)26(28)31/h2-17H,18H2,1H3,(H2,28,31)
    Synonyms
    4'-Carbamoyl-[1,1'-biphenyl]-4-yl methyl(3-(pyridin-4-yl)benzyl)carbamate | WWL70, >=98% (HPLC) | WWL 70 | EX-A2937 |...
  10. JZL184
    CAS: 1101854-58-3 Formula: C27H24N2O9 Molecular Weight: 520.5
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥96%
    ● In Stock — US warehouse, ships to EU* Item #: J401065
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    Technical Identifiers
    IUPAC Name
    (4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate
    SMILES
    C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC6=CC=C(C=C6)[N+](=O)[O-]
    InChIKey
    SEGYOKHGGFKMCX-UHFFFAOYSA-N
    InChI
    1S/C27H24N2O9/c30-26(38-21-5-3-20(4-6-21)29(32)33)28-11-9-17(10-12-28)27(31,18-1-7-22-24(13-18)36-15-34-22)19-2-8-23-25(14-19)37-16-35-23/h1-8,13-14,1show more
    Synonyms
    4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl-(hydroxy)methyl)piperidine-1-carboxylate | AKOS024457824 | HY-15249 | Q27...
  11. JZL184, Inhibitor of Monoacylglycerol lipase
    CAS: 1101854-58-3 Formula: C27H24N2O9 Molecular Weight: 520.5
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
    ● In Stock — US warehouse, ships to EU* Item #: J129444
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    Technical Identifiers
    IUPAC Name
    (4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate
    SMILES
    C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC6=CC=C(C=C6)[N+](=O)[O-]
    InChIKey
    SEGYOKHGGFKMCX-UHFFFAOYSA-N
    InChI
    1S/C27H24N2O9/c30-26(38-21-5-3-20(4-6-21)29(32)33)28-11-9-17(10-12-28)27(31,18-1-7-22-24(13-18)36-15-34-22)19-2-8-23-25(14-19)37-16-35-23/h1-8,13-14,1show more
    Synonyms
    4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl-(hydroxy)methyl)piperidine-1-carboxylate | AKOS024457824 | HY-15249 | Q27...
  12. ABX-1431, Inhibitor of αβ-Hydrolase 6;Inhibitor of Monoacylglycerol lipase;Inhibitor of PLA 2-G7
    CAS: 1446817-84-0 EC Number: 870-188-4 Formula: C20H22F9N3O2 Molecular Weight: 507.39
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: A421645
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    IUPAC Name
    1,1,1,3,3,3-hexafluoropropan-2-yl 4-[[2-pyrrolidin-1-yl-4-(trifluoromethyl)phenyl]methyl]piperazine-1-carboxylate
    SMILES
    C1CCN(C1)C2=C(C=CC(=C2)C(F)(F)F)CN3CCN(CC3)C(=O)OC(C(F)(F)F)C(F)(F)F
    InChIKey
    SQZJGTOZFRNWCX-UHFFFAOYSA-N
    InChI
    1S/C20H22F9N3O2/c21-18(22,23)14-4-3-13(15(11-14)31-5-1-2-6-31)12-30-7-9-32(10-8-30)17(33)34-16(19(24,25)26)20(27,28)29/h3-4,11,16H,1-2,5-10,12H2
    Synonyms
    1,1,1,3,3,3-hexafluoropropan-2-yl 4-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)piperazine-1-carboxylate | BS-1574...
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Frequently Asked Questions

How is the MAGL listing put together?
It draws on reported MAGL annotations within Metabolic Enzyme/Protease and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose a MAGL modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the MAGL entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for MAGL compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For MAGL work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the MAGL compound I need is not listed?
Search by CAS number or SMILES first, since analogs of MAGL compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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