MEK

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  1. Lidocaine hydrochloride
    CAS: 73-78-9 Formula: C14H22N2O.HCl Molecular Weight: 270.8
    ● In Stock — US warehouse, ships to EU* Item #: L276132
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    IUPAC Name
    2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrochloride
    SMILES
    CCN(CC)CC(=O)NC1=C(C=CC=C1C)C.Cl
    InChIKey
    IYBQHJMYDGVZRY-UHFFFAOYSA-N
    InChI
    1S/C14H22N2O.ClH/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H
    Synonyms
    Rucaina hydrochloride | Xilina hydrochloride | Xyloneural | Lidocaine hydrochloride | Lidothesin | Xycaine hydrochlor...
  2. PD 98059 (DMSO solution)
    CAS: 167869-21-8 EC Number: 620-943-7 Formula: C16H13NO3 Molecular Weight: 267.28
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10 mM
    ◐ .Made to order · 8–12 wks Item #: P276564
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    IUPAC Name
    2-(2-amino-3-methoxyphenyl)chromen-4-one
    SMILES
    COC1=CC=CC(=C1N)C2=CC(=O)C3=CC=CC=C3O2
    InChIKey
    QFWCYNPOPKQOKV-UHFFFAOYSA-N
    InChI
    1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
    Synonyms
    PD 98059 | 2-(2-amino-3-methoxyphenyl)-4H-chromen-4-one | 4H-1-Benzopyran-4-one, 2-(2-Amino-3-methoxyp
  3. Binimetinib, Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
    CAS: 606143-89-9 EC Number: 639-995-7 Formula: C17H15BrF2N4O3 Molecular Weight: 441.23
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: M126898
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    IUPAC Name
    6-(4-bromo-2-fluoroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
    SMILES
    CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO
    InChIKey
    ACWZRVQXLIRSDF-UHFFFAOYSA-N
    InChI
    1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
    Synonyms
    AMY9056 | BINIMETINIB [WHO-DD] | D10604 | GTPL7921 | Q19903515 | QO7 | EN300-7411873 | NSC 267219 | SW219910-1 | US11...
  4. SL-327, Inhibitor of mitogen-activated protein kinase kinase 2
    CAS: 305350-87-2 EC Number: 878-717-0 PubChem CID: 9549284 Formula: C16H12F3N3S Molecular Weight: 335.35
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98% mixture of isomers
    ● In Stock — US warehouse, ships to EU* Item #: S125929
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    IUPAC Name
    (Z)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile
    SMILES
    C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F
    InChIKey
    JLOXTZFYJNCPIS-FYWRMAATSA-N
    InChI
    1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
    Synonyms
    CCG-206867 | STL555675 | Benzeneacetonitrile, alpha-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)- | HY-1...
  5. PD 334581
    CAS: 548756-68-9 PubChem CID: 5287529 Formula: C20H19F3IN5O2 Molecular Weight: 545.3
    ● In Stock — US warehouse, ships to EU* Item #: P288537
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    IUPAC Name
    5-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-N-(2-morpholin-4-ylethyl)-1,3,4-oxadiazol-2-amine
    SMILES
    C1COCCN1CCNC2=NN=C(O2)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F
    InChIKey
    LZZYEMSEMRUPIM-UHFFFAOYSA-N
    InChI
    1S/C20H19F3IN5O2/c21-14-3-2-13(18(17(14)23)26-16-4-1-12(24)11-15(16)22)19-27-28-20(31-19)25-5-6-29-7-9-30-10-8-29/h1-4,11,26H,5-10H2,(H,25,28)
    Synonyms
    N-[5-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl]-1,3,4-oxadiazol-2-yl]-4-morpholineethanamine
  6. PD0325901, Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
    CAS: 391210-10-9 EC Number: 687-152-7 Formula: C16H14F3IN2O4 Molecular Weight: 482.19
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ● In Stock — US warehouse, ships to EU* Item #: P125494
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    IUPAC Name
    N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide
    SMILES
    C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOCC(CO)O
    InChIKey
    SUDAHWBOROXANE-SECBINFHSA-N
    InChI
    1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1
    Synonyms
    MIRDAMETINIB [INN] | EN300-108603 | MFCD00056895 | SUDAHWBOROXANE-SECBINFHSA-N | (-)-N-(((R)-2,3-DIHYDROXYPROPYL)OXY)...
  7. PD98059
    CAS: 167869-21-8 EC Number: 620-943-7 Formula: C16H13NO3 Molecular Weight: 267.28
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: P126620
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    IUPAC Name
    2-(2-amino-3-methoxyphenyl)chromen-4-one
    SMILES
    COC1=CC=CC(=C1N)C2=CC(=O)C3=CC=CC=C3O2
    InChIKey
    QFWCYNPOPKQOKV-UHFFFAOYSA-N
    InChI
    1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
    Synonyms
    PD-98059 | 2''-amino-3''-methoxyflavone | 2'-AMINO-3'-METHOXYFLAVONE | BiomolKI_000001 | HMS3654I16 | NCGC00015790-03...
  8. Pimasertib (AS-703026), Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
    CAS: 1236699-92-5 Formula: C15H15FIN3O3 Molecular Weight: 431.2
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: A125227
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    IUPAC Name
    N-[(2S)-2,3-dihydroxypropyl]-3-(2-fluoro-4-iodoanilino)pyridine-4-carboxamide
    SMILES
    C1=CC(=C(C=C1I)F)NC2=C(C=CN=C2)C(=O)NCC(CO)O
    InChIKey
    VIUAUNHCRHHYNE-JTQLQIEISA-N
    InChI
    1S/C15H15FIN3O3/c16-12-5-9(17)1-2-13(12)20-14-7-18-4-3-11(14)15(23)19-6-10(22)8-21/h1-5,7,10,20-22H,6,8H2,(H,19,23)/t10-/m0/s1
    Synonyms
    EMD 1036239 | HY-12042 | N-((2S)-2,3-dihydroxypropyl)-3-((2-fluoro-4-iodophenyl)amino)pyridine-4-carboxamide | NSC755...
  9. U0126
    CAS: 109511-58-2 PubChem CID: 3006531 Formula: C18H16N6S2 Molecular Weight: 380.49
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: U274745
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    IUPAC Name
    (2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile
    SMILES
    C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N
    InChIKey
    DVEXZJFMOKTQEZ-JYFOCSDGSA-N
    InChI
    1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+
    Synonyms
    1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene | bis[Amino[(2-aminophenyl)thio]methylene]-butanedinitril...
  10. U0126-EtOH
    CAS: 1173097-76-1 PubChem CID: 16220066 Formula: C18H16N6S2.C2H6O Molecular Weight: 426.56
    ● In Stock — US warehouse, ships to EU* Item #: U127670
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    IUPAC Name
    (2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile;ethanol
    SMILES
    CCO.C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N
    InChIKey
    CFQULUVMLGZVAF-OYJDLGDISA-N
    InChI
    1S/C18H16N6S2.C2H6O/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22;1-2-3/h1-8H,21-24H2;3H,2H2,1H3/b17-11+,18-12+;
    Synonyms
    U0126 monoethanolate, >=98% (HPLC), powder | (2Z,3Z)-Bis{amino[(2-aminophenyl)sulfanyl]methylidene}butanedinitrile--e...
  11. Lidocaine, Sodium channel alpha subunit blocker
    CAS: 137-58-6 EC Number: 205-302-8 Formula: C14H22N2O Molecular Weight: 234.34
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ● In Stock — US warehouse, ships to EU* Item #: L129221
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    Technical Identifiers
    IUPAC Name
    2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide
    SMILES
    CCN(CC)CC(=O)NC1=C(C=CC=C1C)C
    InChIKey
    NNJVILVZKWQKPM-UHFFFAOYSA-N
    InChI
    1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)
    Synonyms
    Lidocaine (USP:INN:BAN:JAN) | LIDOCAINE COMPONENT OF ORAQIX | ORAQIX COMPONENT LIDOCAINE | 2',6'-Acetoxylidide, 2-(di...
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R&D Use Only Products supplied for research and development use

Frequently Asked Questions

Which compounds are listed for MEK?
Compounds associated with MEK are grouped here under the MAPK/ERK Pathway classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.
How does MEK sit within MAPK/ERK Pathway?
MEK is one target listing within the MAPK/ERK Pathway classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.
What data should I check before ordering a compound from MEK?
For compounds listed under MEK, check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
How do I find related targets or backup compounds for MEK?
Browse the parent MAPK/ERK Pathway listing to reach targets neighbouring MEK, and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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