mGluR

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  1. L-CCG-l, Agonist of mGlu 1 receptor;Agonist of mGlu 2 receptor;Agonist of mGlu 3 receptor;Agonist of mGlu 4 receptor;Agonist of mGlu 5 receptor;Agonist of mGlu 6 receptor;Agonist of mGlu 7 receptor;Agonist of mGlu 8 receptor
    CAS: 117857-93-9 Formula: C6H9NO4 Molecular Weight: 159.14
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%(HPLC)
    ◐ .Made to order · 8–12 wks Item #: L287585
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    IUPAC Name
    (1S,2S)-2-[(S)-amino(carboxy)methyl]cyclopropane-1-carboxylic acid
    SMILES
    C1C(C1C(=O)O)C(C(=O)O)N
    InChIKey
    GZOVEPYOCJWRFC-HZLVTQRSSA-N
    InChI
    1S/C6H9NO4/c7-4(6(10)11)2-1-3(2)5(8)9/h2-4H,1,7H2,(H,8,9)(H,10,11)/t2-,3-,4-/m0/s1
    Synonyms
    AM85789 | L-CCG I | NCGC00024541-02 | SCHEMBL664330 | 2-(Amino-carboxy-methyl)-cyclopropanecarboxylic acid(2S,3S,4S-C...
  2. YM298198 hydrochloride, Allosteric modulator of mGlu 1 receptor
    CAS: 748758-45-4 PubChem CID: 9819432 Formula: C18H22N4OS.HCl Molecular Weight: 378.92
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ◐ .Made to order · 8–12 wks Item #: Y276490
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    IUPAC Name
    7-amino-N-cyclohexyl-N,1-dimethyl-[1,3]thiazolo[3,2-a]benzimidazole-2-carboxamide
    SMILES
    CC1=C(SC2=NC3=C(N12)C=C(C=C3)N)C(=O)N(C)C4CCCCC4
    InChIKey
    KCBXOMYXOBVLED-UHFFFAOYSA-N
    InChI
    1S/C18H22N4OS/c1-11-16(17(23)21(2)13-6-4-3-5-7-13)24-18-20-14-9-8-12(19)10-15(14)22(11)18/h8-10,13H,3-7,19H2,1-2H3
    Synonyms
    6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamidehydrochloride
  3. SIB 1757, Allosteric modulator of mGlu 5 receptor
    CAS: 31993-01-8 PubChem CID: 5218788 Formula: C12H11N3O Molecular Weight: 213.24
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: S287942
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    IUPAC Name
    6-methyl-2-phenyldiazenylpyridin-3-ol
    SMILES
    CC1=NC(=C(C=C1)O)N=NC2=CC=CC=C2
    InChIKey
    LOCPVWIREQIGNQ-UHFFFAOYSA-N
    InChI
    1S/C12H11N3O/c1-9-7-8-11(16)12(13-9)15-14-10-5-3-2-4-6-10/h2-8,16H,1H3
    Synonyms
    NCGC00185991-01 | CHEBI:93722 | SR-01000076142-1 | BCP33033 | BDBM50478347 | DTXSID00425754 | EU-0101161 | CCG-205235...
  4. SIB 1893, Allosteric modulator of mGlu 4 receptor;Allosteric modulator of mGlu 5 receptor
    CAS: 6266-99-5 EC Number: 635-306-9 PubChem CID: 5311432 Formula: C14H13N Molecular Weight: 195.26
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: S286680
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    IUPAC Name
    2-methyl-6-[(E)-2-phenylethenyl]pyridine
    SMILES
    CC1=NC(=CC=C1)C=CC2=CC=CC=C2
    InChIKey
    SISOFUCTXZKSOQ-ZHACJKMWSA-N
    InChI
    1S/C14H13N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-11H,1H3/b11-10+
    Synonyms
    (E/Z)-SIB-1893 | 2-Methyl-6-styryl-pyridine(SIB-1893) | AKOS006279967 | BDBM86715 | HY-102094 | 2-Methyl-6-((E)-styry...
  5. MNI 137, Allosteric modulator of mGlu 2 receptor;Allosteric modulator of mGlu 3 receptor
    CAS: 946619-21-2 Formula: C15H9BrN4O Molecular Weight: 341.16
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ◐ .Made to order · 8–12 wks Item #: M288647
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    IUPAC Name
    4-(8-bromo-2-oxo-1,3-dihydro-1,5-benzodiazepin-4-yl)pyridine-2-carbonitrile
    SMILES
    C1C(=NC2=C(C=C(C=C2)Br)NC1=O)C3=CC(=NC=C3)C#N
    InChIKey
    KMKZCMKOSAKVGY-UHFFFAOYSA-N
    InChI
    1S/C15H9BrN4O/c16-10-1-2-12-14(6-10)20-15(21)7-13(19-12)9-3-4-18-11(5-9)8-17/h1-6H,7H2,(H,20,21)
    Synonyms
    4-(8-Bromo-2,3-dihydro-2-oxo-1H-1,5-benzodiazepin-4-yl)-2-pyridinecarbonitrile | 4-(7-bromo-4-hydroxy-3H-benzo[b][1,4...
  6. MSOP, Antagonist of mGlu 2 receptor;Antagonist of mGlu 6 receptor;Antagonist of mGlu 7 receptor;Antagonist of mGlu 8 receptor
    CAS: 66515-29-5 EC Number: 809-692-6 Formula: C4H10NO6P Molecular Weight: 199.1
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: M275068
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    IUPAC Name
    2-amino-2-methyl-3-phosphonooxypropanoic acid
    SMILES
    CC(COP(=O)(O)O)(C(=O)O)N
    InChIKey
    GSFCOAGADOGIGE-UHFFFAOYSA-N
    InChI
    1S/C4H10NO6P/c1-4(5,3(6)7)2-11-12(8,9)10/h2,5H2,1H3,(H,6,7)(H2,8,9,10)
    Synonyms
    (RS)-?-Methylserine-O-phosphate | 2-AMINO-2-METHYL-3-(PHOSPHONOOXY)PROPANOIC ACID | DTXSID40398271 | Q27074406 | alph...
  7. LSN2463359, Allosteric modulator of mGlu 5 receptor
    CAS: 1401031-52-4 EC Number: 802-759-0 Formula: C16H15N3O Molecular Weight: 265.31
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: L167188
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    IUPAC Name
    N-propan-2-yl-5-(2-pyridin-4-ylethynyl)pyridine-2-carboxamide
    SMILES
    CC(C)NC(=O)C1=NC=C(C=C1)C#CC2=CC=NC=C2
    InChIKey
    STAFRSGTRKNXHF-UHFFFAOYSA-N
    InChI
    1S/C16H15N3O/c1-12(2)19-16(20)15-6-5-14(11-18-15)4-3-13-7-9-17-10-8-13/h5-12H,1-2H3,(H,19,20)
    Synonyms
    BGC03152 | GTPL6394 | 2-Pyridinecarboxamide, N-(1-methylethyl)-5-[2-(4-pyridinyl)ethynyl]- | N-Isopropyl-5-(pyridin-4...
  8. JNJ 16259685, Allosteric modulator of mGlu 1 receptor
    CAS: 409345-29-5 Formula: C20H23NO3 Molecular Weight: 325.41
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥96%
    ● In Stock — US warehouse, ships to EU* Item #: J287450
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    IUPAC Name
    3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl-(4-methoxycyclohexyl)methanone
    SMILES
    COC1CCC(CC1)C(=O)C2=CC3=CC4=C(N=C3C=C2)OCCC4
    InChIKey
    QOTAQTRFJWLFCR-UHFFFAOYSA-N
    InChI
    1S/C20H23NO3/c1-23-17-7-4-13(5-8-17)19(22)14-6-9-18-16(11-14)12-15-3-2-10-24-20(15)21-18/h6,9,11-13,17H,2-5,7-8,10H2,1H3
    Synonyms
    J-110 | (3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl)(4-methoxycyclohexyl)methanone | HB0348 | NCGC00092375-01 | CHEBI:...
  9. VU 0361737, Allosteric modulator of mGlu 4 receptor
    CAS: 1161205-04-4 EC Number: 802-357-5 PubChem CID: 44191096 Formula: C13H11ClN2O2 Molecular Weight: 262.69
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: V129527
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    IUPAC Name
    N-(4-chloro-3-methoxyphenyl)pyridine-2-carboxamide
    SMILES
    COC1=C(C=CC(=C1)NC(=O)C2=CC=CC=N2)Cl
    InChIKey
    ARYUXFNGXHNNDM-UHFFFAOYSA-N
    InChI
    1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)
    Synonyms
    AC-32871 | VU 0361737 | VU0361737 | VU-0361737 | J-003384 | AKOS024457762 | BCP06488 | Benzo-1,4-quinone dioxime # | ...
  10. VU 0364770, Allosteric modulator of mGlu 4 receptor
    CAS: 61350-00-3 EC Number: 111-965-3 PubChem CID: 836002 Formula: C12H9ClN2O Molecular Weight: 232.67
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: V129525
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    Technical Identifiers
    IUPAC Name
    N-(3-chlorophenyl)pyridine-2-carboxamide
    SMILES
    C1=CC=NC(=C1)C(=O)NC2=CC(=CC=C2)Cl
    InChIKey
    SUYUTNCKIOLMAJ-UHFFFAOYSA-N
    InChI
    1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)
    Synonyms
    HY-100588 | HMS3884L20 | VU 0364770 | N-(3-chloro-phenyl)-pyridine-2-carboxamide | N-(3-chlorophenyl)pyridine-2-carbo...
  11. VU 0409551, Allosteric modulator of mGlu 5 receptor
    CAS: 1363281-27-9 PubChem CID: 56846694 Formula: C20H17FN2O3 Molecular Weight: 352.36
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: V288400
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    IUPAC Name
    (4-fluorophenyl)-[2-(phenoxymethyl)-6,7-dihydro-4H-[1,3]oxazolo[5,4-c]pyridin-5-yl]methanone
    SMILES
    C1CN(CC2=C1N=C(O2)COC3=CC=CC=C3)C(=O)C4=CC=C(C=C4)F
    InChIKey
    QUZLMKNNIUSREV-UHFFFAOYSA-N
    InChI
    1S/C20H17FN2O3/c21-15-8-6-14(7-9-15)20(24)23-11-10-17-18(12-23)26-19(22-17)13-25-16-4-2-1-3-5-16/h1-9H,10-13H2
    Synonyms
    JNJ-46778212 | VU040955 | [6,7-Dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](4-fluorophenyl)methanone
  12. VU 0422288, Allosteric modulator of mGlu 8 receptor
    CAS: 1630936-95-6 PubChem CID: 73058507 Formula: C17H11Cl2N3O2 Molecular Weight: 360.19
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: V287914
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    Technical Identifiers
    IUPAC Name
    N-[3-chloro-4-(5-chloropyridin-2-yl)oxyphenyl]pyridine-2-carboxamide
    SMILES
    C1=CC=NC(=C1)C(=O)NC2=CC(=C(C=C2)OC3=NC=C(C=C3)Cl)Cl
    InChIKey
    MZRLPXFGQKQHST-UHFFFAOYSA-N
    InChI
    1S/C17H11Cl2N3O2/c18-11-4-7-16(21-10-11)24-15-6-5-12(9-13(15)19)22-17(23)14-3-1-2-8-20-14/h1-10H,(H,22,23)
    Synonyms
    ML 396 | N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide | ML396 | N-(3-Chloro-4-((5-chloropyr...
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Frequently Asked Questions

How is the mGluR listing put together?
It draws on reported mGluR annotations within Neuronal Signaling and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose a mGluR modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the mGluR entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for mGluR compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For mGluR work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the mGluR compound I need is not listed?
Search by CAS number or SMILES first, since analogs of mGluR compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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