Na+/H+ Exchanger (NHE)

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  1. Zoniporide dihydrochloride
    CAS: 241799-10-0 PubChem CID: 22267855 Formula: C17H16N6O.2HCl Molecular Weight: 393.27
    ◐ .Made to order · 8–12 wks Item #: Z287415
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    IUPAC Name
    5-cyclopropyl-N-(diaminomethylidene)-1-quinolin-5-ylpyrazole-4-carboxamide;dihydrochloride
    SMILES
    C1CC1C2=C(C=NN2C3=CC=CC4=C3C=CC=N4)C(=O)N=C(N)N.Cl.Cl
    InChIKey
    ARZNPJAGKWHEHT-UHFFFAOYSA-N
    InChI
    1S/C17H16N6O.2ClH/c18-17(19)22-16(24)12-9-21-23(15(12)10-6-7-10)14-5-1-4-13-11(14)3-2-8-20-13;;/h1-5,8-10H,6-7H2,(H4,18,19,22,24);2*1H
    Synonyms
    CP 597396 | [1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine dihydrochloride
  2. BI-9627 hydrochloride
    CAS: 1422252-46-7 PubChem CID: 121513866 Formula: C16H19F3N4O2(free) Molecular Weight: 356.34(free)
    ● In Stock — US warehouse, ships to EU* Item #: B286959
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    IUPAC Name
    4-(1-acetylpiperidin-4-yl)-N-(diaminomethylidene)-3-(trifluoromethyl)benzamide;hydrochloride
    SMILES
    CC(=O)N1CCC(CC1)C2=C(C=C(C=C2)C(=O)N=C(N)N)C(F)(F)F.Cl
    InChIKey
    SLSZLEROFKLICF-UHFFFAOYSA-N
    InChI
    1S/C16H19F3N4O2.ClH/c1-9(24)23-6-4-10(5-7-23)12-3-2-11(14(25)22-15(20)21)8-13(12)16(17,18)19;/h2-3,8,10H,4-7H2,1H3,(H4,20,21,22,25);1H
    Synonyms
    BIX Hydrochloride | BIX HCl | Benzamide, 4-(1-acetyl-4-piperidinyl)-N-(aminoiminomethyl)-3-(trifluoromethyl)-, hydroc...
  3. Dimethylamiloride hydrochloride
    CAS: 2235-97-4 Formula: C8H12ClN7O.HCl Molecular Weight: 294.14
    ● In Stock — US warehouse, ships to EU* Item #: D275816
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    IUPAC Name
    3-amino-6-chloro-N-(diaminomethylidene)-5-(dimethylamino)pyrazine-2-carboxamide;hydrochloride
    SMILES
    CN(C)C1=NC(=C(N=C1Cl)C(=O)N=C(N)N)N.Cl
    InChIKey
    IIUPTHVVXMBJMQ-UHFFFAOYSA-N
    InChI
    1S/C8H12ClN7O.ClH/c1-16(2)6-4(9)13-3(5(10)14-6)7(17)15-8(11)12;/h1-2H3,(H2,10,14)(H4,11,12,15,17);1H
    Synonyms
    DMA.HCl | UNII-52W30K1Q9Q | 3-Amino-5-(N,N-dimethylamino)-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide | 5-(N,N-D...
  4. EIPA, Allosteric modulator of α 2A-adrenoceptor;Channel blocker of ASIC1;Channel blocker of TRPP2
    CAS: 1154-25-2 EC Number: 634-217-2 Formula: C11H18ClN7O Molecular Weight: 299.76
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95%
    ● In Stock — US warehouse, ships to EU* Item #: N132356
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    IUPAC Name
    3-amino-6-chloro-N-(diaminomethylidene)-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamide
    SMILES
    CCN(C1=NC(=C(N=C1Cl)C(=O)N=C(N)N)N)C(C)C
    InChIKey
    QDERNBXNXJCIQK-UHFFFAOYSA-N
    InChI
    1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
    Synonyms
    5-(Ethylisopropyl)amiloride | Ethylisopropyl amiloride | EU-0100045 | HY-101840 | SMR000326875 | Tox21_500045 | 3-Ami...
  5. Monensin sodium salt
    CAS: 22373-78-0 EC Number: 244-941-7 Formula: C36H61NaO11 Molecular Weight: 692.85
    Solid ≥90%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: M163019
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    IUPAC Name
    sodium;(2S,3R,4S)-4-[(2S,5R,7S,8R,9S)-2-[(2R,5S)-5-ethyl-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxoshow more
    SMILES
    CCC1(CCC(O1)C2(CCC3(O2)CC(C(C(O3)C(C)C(C(C)C(=O)[O-])OC)C)O)C)C4C(CC(O4)C5C(CC(C(O5)(CO)O)C)C)C.[Na+]
    InChIKey
    XOIQMTLWECTKJL-FBZUZRIGSA-M
    InChI
    1S/C36H62O11.Na/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)show more
    Synonyms
    AKOS025147337 | CAS-22373-78-0 | DTXSID2045573 | HMS2097E18 | 4-[2-[5-Ethyl-5-[5-[6-hydroxy-6-(hydroxymethyl)-3,5-dim...
  6. Monensin sodium salt
    CAS: 22373-78-0 EC Number: 244-941-7 Formula: C36H61NaO11 Molecular Weight: 692.85
    Solid ≥97%
    ● In Stock — US warehouse, ships to EU* Item #: M118287
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    IUPAC Name
    sodium;(2S,3R,4S)-4-[(2S,5R,7S,8R,9S)-2-[(2R,5S)-5-ethyl-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxoshow more
    SMILES
    CCC1(CCC(O1)C2(CCC3(O2)CC(C(C(O3)C(C)C(C(C)C(=O)[O-])OC)C)O)C)C4C(CC(O4)C5C(CC(C(O5)(CO)O)C)C)C.[Na+]
    InChIKey
    XOIQMTLWECTKJL-FBZUZRIGSA-M
    InChI
    1S/C36H62O11.Na/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)show more
    Synonyms
    AKOS025147337 | CAS-22373-78-0 | DTXSID2045573 | HMS2097E18 | 4-[2-[5-Ethyl-5-[5-[6-hydroxy-6-(hydroxymethyl)-3,5-dim...
  7. Cariporide
    CAS: 159138-80-4 Formula: C12H17N3O3S Molecular Weight: 283.35
    ● In Stock — US warehouse, ships to EU* Item #: C286810
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    IUPAC Name
    N-(diaminomethylidene)-3-methylsulfonyl-4-propan-2-ylbenzamide
    SMILES
    CC(C)C1=C(C=C(C=C1)C(=O)N=C(N)N)S(=O)(=O)C
    InChIKey
    IWXNYAIICFKCTM-UHFFFAOYSA-N
    InChI
    1S/C12H17N3O3S/c1-7(2)9-5-4-8(11(16)15-12(13)14)6-10(9)19(3,17)18/h4-7H,1-3H3,(H4,13,14,15,16)
    Synonyms
    N-carbamimidoyl-3-methanesulfonyl-4-(propan-2-yl)benzamide | AC-14535 | 3-methylsulfonyl-4-i-propylbenzoylguanidine |...
  8. Cariporide
    CAS: 159138-80-4 Formula: C12H17N3O3S Molecular Weight: 283.35
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: C421903
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    IUPAC Name
    N-(diaminomethylidene)-3-methylsulfonyl-4-propan-2-ylbenzamide
    SMILES
    CC(C)C1=C(C=C(C=C1)C(=O)N=C(N)N)S(=O)(=O)C
    InChIKey
    IWXNYAIICFKCTM-UHFFFAOYSA-N
    InChI
    1S/C12H17N3O3S/c1-7(2)9-5-4-8(11(16)15-12(13)14)6-10(9)19(3,17)18/h4-7H,1-3H3,(H4,13,14,15,16)
    Synonyms
    N-carbamimidoyl-3-methanesulfonyl-4-(propan-2-yl)benzamide | AC-14535 | 3-methylsulfonyl-4-i-propylbenzoylguanidine |...
  9. KR-32568
    CAS: 852146-73-7 Formula: C13H12FN3O2 Molecular Weight: 261.25
    ● In Stock — US warehouse, ships to EU* Item #: K336935
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    IUPAC Name
    N-(diaminomethylidene)-5-(5-fluoro-2-methylphenyl)furan-2-carboxamide
    SMILES
    CC1=C(C=C(C=C1)F)C2=CC=C(O2)C(=O)N=C(N)N
    InChIKey
    DTLDHYBZLVASJQ-UHFFFAOYSA-N
    InChI
    1S/C13H12FN3O2/c1-7-2-3-8(14)6-9(7)10-4-5-11(19-10)12(18)17-13(15)16/h2-6H,1H3,(H4,15,16,17,18)
    Synonyms
    N-(Aminoiminomethyl)-5-(5-fluoro-2-methylphenyl)-2-furancarboxamide
  10. Rimeporide
    CAS: 187870-78-6 Formula: C11H15N3O5S2 Molecular Weight: 333.38
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Made to order · 8–12 wks Item #: R412316
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    IUPAC Name
    N-(diaminomethylidene)-2-methyl-4,5-bis(methylsulfonyl)benzamide
    SMILES
    CC1=CC(=C(C=C1C(=O)N=C(N)N)S(=O)(=O)C)S(=O)(=O)C
    InChIKey
    GROMEQPXDKRRIE-UHFFFAOYSA-N
    InChI
    1S/C11H15N3O5S2/c1-6-4-8(20(2,16)17)9(21(3,18)19)5-7(6)10(15)14-11(12)13/h4-5H,1-3H3,(H4,12,13,14,15)
    Synonyms
    N-diaminomethylene-2-methyl-4,5-di(methylsulfonyl)benzamide | D80911 | EMD-87580 pound>>EMD 87580 pound>>EMD87580 | A...
  11. Tenapanor, Inhibitor of Sodium/hydrogen exchanger 3
    CAS: 1234423-95-0 Formula: C50H66Cl4N8O10S2 Molecular Weight: 1145.05
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
    ● In Stock — US warehouse, ships to EU* Item #: T614379
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    IUPAC Name
    1-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-3-[4-[2-[2-[2-[[3-[(4S)-6,8-dichlshow more
    SMILES
    CN1CC(C2=C(C1)C(=CC(=C2)Cl)Cl)C3=CC(=CC=C3)S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)C4=CC=CC(=C4)C5CN(CC6=C5C=C(C=C6Cl)Cl)C
    InChIKey
    DNHPDWGIXIMXSA-CXNSMIOJSA-N
    InChI
    1S/C50H66Cl4N8O10S2/c1-61-31-43(41-27-37(51)29-47(53)45(41)33-61)35-7-5-9-39(25-35)73(65,66)59-15-19-71-23-21-69-17-13-57-49(63)55-11-3-4-12-56-50(64)show more
    Synonyms
    tenapanorum | WYD79216A6 | AC-36104 | US10272079, Compound 002 | HY-15991 | (S)-3-hydroxy-2-methyl-Propanoate | Tenap...
  12. Zoniporide
    CAS: 241800-98-6 EC Number: 695-536-0 PubChem CID: 6433110 Formula: C17H16N6O Molecular Weight: 320.35
    Solid ≥97%
    ● In Stock — US warehouse, ships to EU* Item #: N633068
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    Technical Identifiers
    IUPAC Name
    5-cyclopropyl-N-(diaminomethylidene)-1-quinolin-5-ylpyrazole-4-carboxamide
    SMILES
    C1CC1C2=C(C=NN2C3=CC=CC4=C3C=CC=N4)C(=O)N=C(N)N
    InChIKey
    GDXBRVCQGGKXJY-UHFFFAOYSA-N
    InChI
    1S/C17H16N6O/c18-17(19)22-16(24)12-9-21-23(15(12)10-6-7-10)14-5-1-4-13-11(14)3-2-8-20-13/h1-5,8-10H,6-7H2,(H4,18,19,22,24)
    Synonyms
    Zoniporide | 5-cyclopropyl-N-(diaminomethylidene)-1-quinolin-5-ylpyrazole-4-carboxamide | 8841R2UJPG | N-carbamimidoy...
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Frequently Asked Questions

Which compounds are listed for Na+/H+ Exchanger (NHE)?
Compounds associated with Na+/H+ Exchanger (NHE) are grouped here under the Membrane Transporter/Ion Channel classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.
How does Na+/H+ Exchanger (NHE) sit within Membrane Transporter/Ion Channel?
Na+/H+ Exchanger (NHE) is one target listing within the Membrane Transporter/Ion Channel classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.
What data should I check before ordering a compound from Na+/H+ Exchanger (NHE)?
For compounds listed under Na+/H+ Exchanger (NHE), check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
How do I find related targets or backup compounds for Na+/H+ Exchanger (NHE)?
Browse the parent Membrane Transporter/Ion Channel listing to reach targets neighbouring Na+/H+ Exchanger (NHE), and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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